DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir8a and LOC100334689

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	XP_017206939.1	Gene:	LOC100334689 / 100334689	-ID:	-	Length:	991	Species:	Danio rerio

Alignment Length:	1037	Identity:	260/1037 - (25%)
Similarity:	424/1037 - (40%)	Gaps:	259/1037 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SEVLKITFWIEP------VQR-----AEFDTDIAMVLKELDALRLDVK--------VDDTTLTLT 62
            |.::.:.|||:.      |.|     .:.|..:|:|..|..|.:..|.        :.:||||
Zfish    12 SAIIVVLFWIQSSFGMPHVIRIGGIFEQTDGPVALVSSEELAFKFAVNNINRNRTLLPNTTLT-- 74

  Fly    63 RSEDGLDMQRF------------CEILSTVGASAVIDLTYSHWEEGYNLVRS----LGIGYVRLE 111
                 .|:||.            |:.|| :|..|:...::|   ...|.|:|    |.:.::::.
Zfish    75 -----YDIQRINIYDSFEASRKACDQLS-LGVVAIFGPSHS---SSSNAVQSICNALEVPHIQVR 130

  Fly   112 RIMRP-------FLDMFGD-------------FMRQKRANNV---AMVFMNARDAVEAMQQMLVG 153
            ....|       :.:::.|             |::.|.|..|   :...:..::.:.|..:..:.
Zfish   131 WKHHPMDNRDTFYANLYPDYSSLSYAILDLVQFLKWKTATVVYDDSTGLIRLQELIMAPSRYNIR 195

  Fly   154 YPFRTLIMDASQTDPGQHFLERIRSLR----PAPTYIALFARAAAMNGIFEKVQKADLFQRPLEW 214
            ...|.|.||...|.|....::|.|..|    .:.|..|...:.|.|.|:..:.           :
Zfish   196 LKIRQLPMDTVDTRPLLKEMKRSREFRIIFDCSHTMAAQILKQAQMMGMMTEY-----------Y 249

  Fly   215 HFVFLDTRDRVFKYRRQAELCTRFTLNPRAICRSMPMPDLYCGSGFTMQRAMLLNV----LRSLI 275
            |::|.                   ||:..||...   |..:||...|..|  :|||    :.|::
Zfish   250 HYIFT-------------------TLDLMAINLE---PYRFCGVNMTGFR--ILNVDNPQVASIV 290

  Fly   276 N----AAQVSPGYPLAIYQDCNATASSSEVSDPLEKDDYNWLDMVH-WSNFLAYAPPLP------ 329
            .    ..|:.|            ...|..:...:..|.....|.|| .|....:||.:.
Zfish   291 EKWSLERQIPP------------KPDSGLLEGIMTTDAALTYDAVHIVSVSYQHAPQMTVNSLQC 343

  Fly   330 --HIQDQF---------QSPVPGLT--FAVNISAG--------YYSSEHEAKTDLAAWSSVGEMR 373
              |...:|         :|...|||  ...|.:.|        ..|.:.:....:..||:.|.:.
Zfish   344 HRHKPWRFGGRFMSFIKESHWDGLTGRLCFNRTTGLRTDFDLDIVSLKEDGLQKVGKWSASGGLN 408

  Fly   374 L--------LNETISPARRFFRIGTAESIPWSYLRREEGTGELI-RDRSGLPIWEGYCIDFIIRL 429
            :        :|.|.|.:.|...|.|....|:..|::.:..  |: .||     :||:|||.:..|
Zfish   409 ITEVPRQNGMNITDSLSNRSLVITTILEEPYVMLKKSDKA--LVGNDR-----FEGFCIDLLKEL 466

  Fly   430 SQKLNFEFEIVAPEVGHMGELNELGEWDGVVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQ 494
            :..|.|.:||.....|..|..::.|:|:|::.:|:....|.|:|.|.:...||:.|||..|:. .
Zfish   467 ASILGFSYEIHLVPDGKYGFQDDKGQWNGMIRELMEHRADLAVAPLTITFMREKAIDFSKPFL-N 530

  Fly   495 TGISIAIRKPVRRTS-LFKFMTVLRLEVWLSIVAALVGTAIMIWFMDKYSPYSSRNNRQAYPYAC 558
            |||||..|||....| .|.|:..:..::|:.|:.|.:|.:.:::.:.::|||...:   |:|  |
Zfish   531 TGISILYRKPNSTNSGFFSFLNPMTPDIWVYILLAYLGVSCVLFVIARFSPYEWYD---AHP--C 590

  Fly   559 --------REFTLRESFWFALTSFTPQGGGEAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLT 615
                    ..|||..||||.:.|...||....|||:|.|::...:|.|.:::::::|||||||||
Zfish   591 NPGSDVVENNFTLLNSFWFGVGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLT 655

  Fly   616 VERMQTPVQSLEQLARQSRINYTVVKDSDTHQYFVNMKFAEDTLYRMWKELALNASKDFKKFRIW 680
            ||||.:||.|.:.||:|::|.|.||||..|..:|  .|....|..:||..::...|..|
Zfish   656 VERMDSPVDSADDLAKQTKIEYGVVKDGATMSFF--KKSRVSTFEKMWAFMSSRQSTSF------ 712

  Fly   681 DYPIKEQYGHILLAINSSQPVADAKEGFANVDAHENADYAFIHDSAEIKYEITRNCNLTEVGEVF 745
                                |...::|...|   ..:|||.:.:|..|:|...||||||:||.:.
Zfish   713 --------------------VKSIEDGIQRV---LKSDYALLMESTTIEYVTRRNCNLTQVGGII 754

  Fly   746 AEQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYWNQSNLPNCPLSEDQEGIT----LES 806
            ..:.|.:...:||...|:::.|||.:.:|.....||.|:|:.|   :|  .||:...|    :::
Zfish   755 DSKGYGIGTPKGSPYRDKITIAILGILEDGRLHMLKEKWWSGS---SC--LEDERYETGPMGIQN 814

  Fly   807 LGGVFIATLFGLVLAMMTLGMEVLYYKKKQNALE-------------ITQVRPVNDSSGSGGNSS 858
            |||:||....||||::.....|.:|..:|....|             :..||...::.
Zfish   815 LGGIFIVLASGLVLSVFVAIGEFIYKLRKTAEREQVFLQCGDGRDQTVVHVRETGEAQ------- 872

  Fly   859 TAPPTATSTTKQAWHIPVLEAEEKPAKVSPPPSFETATFRGKKLPARIT---LGDGKFKPRH 917
             |||.|.|      |.....:::......|.|:.:.......:..||::   ||||..  ||
Zfish   873 -APPAAAS------HAEDGRSDQHALLQRPSPARKGQHELQHRDDARVSMTCLGDGHL--RH 925

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	133/412 (32%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	99/309 (32%)
LOC100334689	XP_017206939.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810