DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir8a and grin2cb

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	XP_009305071.2	Gene:	grin2cb / 100333648	ZFINID:	ZDB-GENE-100308-2	Length:	1328	Species:	Danio rerio

Alignment Length:	1040	Identity:	211/1040 - (20%)
Similarity:	361/1040 - (34%)	Gaps:	285/1040 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 LDALRLDVKVDDTT--LTLTR--------------SEDGLDMQRFCEILSTV------------G 81
            |:...:.|.|:||.  ..|||              .||.:|.:...:||..|            |
Zfish    68 LEVNPITVLVNDTNPRALLTRLCQTMAAESLHGVVFEDDVDSEAVAQILDFVSSQTSIPIVGISG 132

  Fly    82 ASAVIDLTYSHWEEGYNLVRSLGIGYVRLERIMRPFLDMFGDFMRQKRANNVAMVFMNARDAVEA 146
            .|||:   ..|..:|                  ..||.|.....:|                :.|
Zfish   133 GSAVV---IPHKADG------------------STFLQMGASIDQQ----------------INA 160

  Fly   147 MQQMLVGYPFRTLIMDASQTDPGQHFLERIRSLRPAPTY------IALFARAAAMNGIFEK--VQ 203
            |.:::..|.:...::..|.....:.|::.|||......:      :..|..:...|.|..:  :|
Zfish   161 MFKVMEEYNWGNFVVITSLYPGYETFVDYIRSFTDTSYFLWELQDVLSFEMSVGANDIRTRRLLQ 225

  Fly   204 KADLFQRPLEWHFVFLDTRDRVFKYRRQAELCTRFTLNPRAICRSMPMPDLYCGSGFTMQRAMLL 268
            :.|     .:.:.|:....:..:.:|..:::   ..|.|..|   ..:|.|..|:......|...
Zfish   226 QVD-----SQVYLVYCSHEEAQYLFRMASDV---GLLGPGYI---WIVPSLAVGNPEAAPPASFP 279

  Fly   269 NVLRSLIN-------AAQVSPGYPLAI----------------YQDCNATASSSEVSDPLEKDDY 310
            ..:.|:|.       ..:|..|..:.:                :.||     ||.|........:
Zfish   280 VGVISIITDRWRKTLRQRVREGVAIIVKGVHSFHKHRGFIPEGHSDC-----SSPVKSYANNSLF 339

  Fly   311 NWLDMVHWSNFLAYAPPLPHIQDQFQSPVPGLTFAVNISAGYYSSEHEAKTDLAAWSSVG----- 370
            ..:..|.|.          |....|.|.    .:..|.|....:.:.|..     |..||
Zfish   340 RHMLNVSWE----------HKDLSFNSD----GYLTNPSMVIIALDRENH-----WDKVGSYEGG 385

  Fly   371 --EMRL-----LNETISPA--RRFFRIGTAESIPWSYLRR-EEGTGELIRDRSGLP--------- 416
              :||.     ....:.|.  .|...:.|.|..|:..:.. :..||..:|:.  :|
Zfish   386 ILQMRYPVWPRYGSFLEPVSDNRHLTVATLEERPFVIVESVDPATGTCVRNT--VPCRRQSNRTE 448

  Fly   417 ------------IWEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELNELGEWDGVVGDLVRGETD 469
                        ..:|:|||.:.:||:.:.|.:::.....|..|::.. |.|:|::|::.....|
Zfish   449 SIIGHTEPYTKLCCKGFCIDILKKLSRTIKFSYDLYLVTNGKHGKMVR-GVWNGMIGEVFYKRAD 512

  Fly   470 FAIAALKMYSEREEVIDFLPPYYEQTGISIAIRKPVRRTSLFKFMTVLRLEVW-LSIVAALVGTA 533
            .||.:|.:..||.|::||..|:.| ||||:.:.:.....|...|:......|| :..|..|...|
Zfish   513 MAIGSLTINEERSEIVDFSVPFVE-TGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVA 576

  Fly   534 IMIWFMDKYSPYS-SRNNRQAYPYACREFTLRESFW----FALTSFTPQGGGEAPKAISGRMLVA 593
            :.::..:.:||.. :|:...|.......||:.:|.|    ....:..|.   |.||..:.:::|.
Zfish   577 VTVFVFEYFSPVGYNRSLVSAKAPGGPTFTIGKSVWLLWGIVFNNSVPI---ENPKGTTSKIMVL 638

  Fly   594 AYWLFVVLMLATFTANLAAFLTVERMQTPVQSLE----------------------QLARQSRIN 636
            .:..|.|:.||::|||||||:..|:....|..|.                      ...|..|.|
Zfish   639 VWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQKPQEHYPPFRFGTVPNGSTERNIRSN 703

  Fly   637 YTVVKDSDTHQYFVNMKFAEDTLYRMWKELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQPV 701
            |   .|..||....|.|..|:         |||:.|..|
Zfish   704 Y---PDMHTHMIKYNQKGVEE---------ALNSLKTGK-------------------------- 730

  Fly   702 ADAKEGFANVDAHENADYAFIHDSAEIKYEITRN--CNLTEV--GEVFAEQPYAVAVQQGSHLGD 762
                     :|       |||:|:|.:.|...::  |.|..:  |:|||...|.:|:|:.|....
Zfish   731 ---------LD-------AFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIALQKDSRWKR 779

  Fly   763 ELSYAILELQKDRFFEELKAKYWNQSNLPNCPLSEDQEGITLESLGGVFIATLFGLVLAMMTLGM 827
            .:..|:|:...|...:.|:. .|......|.........:.::::.|||...|..:.|:::....
Zfish   780 PIDLALLQFLGDGDTQRLET-VWLSGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAW 843

  Fly   828 EVLYYKKKQNALE--------ITQVRPV----NDSSGSGGNSSTAPPTATSTTKQAWHIPVLEAE 880
            |.|.|.|.::::.        :...|.:    |.....|.::....|..|:...||..:.:|:..
Zfish   844 EHLLYWKLRHSVHKSDRLDFLLAISRGIYSCFNGVEDIGRSTGIQNPDITANYAQANMLKMLQTA 908

  Fly   881 E---KPAKV-----SPPPSFETATFRGKKLPARITLGDGKFK-PRHGLYARRNLGASDSHSGYME 936
            :   ..|||     :...:.|..:.|...|||||.|.....| |.|..|.   ...:::|..:|:
Zfish   909 KDIVSSAKVENSLDNATKTIENWSRRSGSLPARIPLVTTTEKVPGHFSYI---ANVAENHIPHMQ 970

Fly 937 936
Zfish 971 970

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	106/456 (23%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	74/329 (22%)
grin2cb	XP_009305071.2	PBP1_iGluR_NMDA_NR2	37..396	CDD:107373	68/399 (17%)
		PBP2_iGluR_NMDA_Nr2	407..808	CDD:270436	107/462 (23%)
		NMDAR2_C	845..>932	CDD:313729	15/86 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900