DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir8a and LOC100149482

DIOPT Version :9

Sequence 1:	NP_727328.1	Gene:	Ir8a / 31867	FlyBaseID:	FBgn0052704	Length:	936	Species:	Drosophila melanogaster
Sequence 2:	XP_009290417.1	Gene:	LOC100149482 / 100149482	-ID:	-	Length:	1959	Species:	Danio rerio

Alignment Length:	613	Identity:	141/613 - (23%)
Similarity:	246/613 - (40%)	Gaps:	149/613 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   365 AWSSVGEMRLLNETISPA--RRFFRIGTAESIPWSYLR-REEGTGELIRD-------------RS 413
            |||..|..      :.|.  .:..|:.|.|..|:..:. .:..:|..|||             :.
Zfish   418 AWSRYGPF------LQPPDDAQHLRVVTLEERPFVIVELADAASGTCIRDSVPCRRPLNASALQE 476

  Fly   414 GL-PI---WEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELNELGEWDGVVGDLVRGETDFAIAA 474
            |: |:   .:|:|||.:.||::.:.|.:::.....|..|:..: |.|:|:||::|....|.||.:
Zfish   477 GVAPVKQCCKGFCIDILKRLARIVGFTYDLYLVTNGKHGKKID-GVWNGMVGEVVYKRADMAIGS 540

  Fly   475 LKMYSEREEVIDFLPPYYEQTGISIAIRKPVRRTSLFKFMTVLRLEVW-LSIVAALVGTAIMIWF 538
            |.:..||.||:||..|:.| ||||:.:.:.....|...|:......|| :..|..|...|:.::.
Zfish   541 LTINEERSEVVDFSVPFVE-TGISVMVSRSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFI 604

  Fly   539 MDKYSPYSSRNNRQAYPYA-CREFTLRESFW--FALTSFTPQGGGEAPKAISGRMLVAAYWLFVV 600
            .:.:||.....:.|:...| ..:||:.:|.|  :||. |......|.||..:.:::|..:..|.|
Zfish   605 FEFFSPVGYNRSLQSGKKAGGSKFTIGKSIWLLWALV-FNNSVPVENPKGTTSKIMVLVWAFFAV 668

  Fly   601 LMLATFTANLAAFLTVE------------RMQTPVQSLEQL----------ARQSRINYTVVKDS 643
            :.||::|||||||:..|            :.|.|.:....|          .:..|.||     .
Zfish   669 IFLASYTANLAAFMIQEEYIDTVSGLSDKKFQHPTEQYPPLKFGTVPNGSTEKNIRSNY-----P 728

  Fly   644 DTHQYFV--NMKFAEDTLYRMWKELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQPVADAKE 706
            |.|||.|  |.|..||.:                             .|:             |.
Zfish   729 DMHQYMVKYNQKSVEDAI-----------------------------SHL-------------KT 751

  Fly   707 GFANVDAHENADYAFIHDSAEIKYEITRN--CNLTEV--GEVFAEQPYAVAVQQGSHLGDELSYA 767
            |  .:|       |||:|:|.:.|...::  |.:..:  |:|||...|.:|:.:.|.....|..|
Zfish   752 G--KLD-------AFIYDAAVLNYMARKDEGCKVMTIGSGKVFATTGYGIALIKNSRWKRPLDLA 807

  Fly   768 ILELQKDRFFEELKAKYWNQSNLPNCPLSEDQEGITLESLGGVFIATLFGLVLAMMTLGMEVLYY 832
            :|:|..|...|.|: :.|......|..:......:.::::.|||...|..:.|:::....|.|.|
Zfish   808 LLQLVGDDEIEMLE-RLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLVY 871

  Fly   833 KKKQNALE-----------------ITQVRPVNDSSGSGG---------NSSTAPPTATSTTKQA 871
            .:.::.:.                 :.......|.:..||         :::..|.:::.....|
Zfish   872 WRLRHCMSKMGQSGKLDFLLAFSRGMYSCCSFEDETAQGGAKVTVSGHHHTAMVPTSSSHVVTSA 936

  Fly   872 WHIPVL-----EAEEKPAKVSPPPSFET 894
            ...|.:     :.:::|.:..||.|::|
Zfish   937 VSNPAIAMVQQQQQQQPQQPQPPQSYKT 964

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	115/452 (25%)
Ir8a	NP_727328.1	Lig_chan	520..818	CDD:278489	78/329 (24%)
LOC100149482	XP_009290417.1	PBP1_iGluR_NMDA_NR2	44..421	CDD:107373	2/2 (100%)
		PBP2_iGluR_NMDA_Nr2	433..831	CDD:270436	116/457 (25%)
		HisJ	<487..>570	CDD:223904	31/84 (37%)
		Lig_chan	585..857	CDD:278489	78/329 (24%)
		NMDAR2_C	868..>900	CDD:287527	2/31 (6%)
		FAM76	<1763..>1856	CDD:292665
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900