Protein Alignment Ir8a and gria4

DIOPT Version :10

• Sequence 1: NP_727328.1
• Gene: Ir8a / 31867
• FlyBaseID: FBgn0052704
• Length: 936
• Species: Drosophila melanogaster
• Sequence 2: XP_031751480.1
• Gene: gria4 / 100125052
• XenbaseID: XB-GENE-5838893
• Length: 902
• Species: Xenopus tropicalis
• Alignment Length: 876
• Identity: 207/876 - (23%)
• Similarity: 357/876 - (40%)
• Gaps: 225/876 - (25%)

  Fly    35 DTDIAMVLKELDALR-----LDVKVDDTTLTLTRSEDGLDMQRFCEILSTVGASAVIDLTYSHWE 94
            |.....:|::||..:     :|.:|:             .:|...|.:.:||...
 Frog   191 DASYRRLLEDLDRRQENKFVIDCEVE-------------RLQNILEQIVSVGKHV---------- 232

  Fly    95 EGYN-LVRSLGIGYVRLERIMRPFLDMFGDFMRQKRANNVAMVFMNARDAVEAMQQMLVGYPFRT 158
            :||: ::.:||...:.|:|.|....::.|          ..:|..|.....|.||:      ::|
 Frog   233 KGYHYIIANLGFKDISLDRFMHGGANVTG----------FQLVDFNTPIVTELMQR------WKT 281

  Fly   159 LIMDASQTD-PGQHFLERIRSLRPAPTYIALFARAAAMNGIFEKVQKADLFQRPLEWHFVFLDTR 222
            |    .|.: ||.....:..|   |.||..:...|.|...:  :.||.||.:
 Frog   282 L----DQREYPGSESPPKYTS---ALTYDGVLVMAEAFRIL--RRQKIDLSR------------- 324

  Fly   223 DRVFKYRRQAELCTRFTLNPRAICRSMPMPDLYCGSGFTMQRAMLLNVLRSLINAAQVSPGYPLA 287
                  |..|..|   ..||.|     |.     |.|..|:|.:....::.|....|
 Frog   325 ------RGNAGDC---LANPAA-----PW-----GQGIDMERTLKQVRIQGLTGNIQ-------- 362

  Fly   288 IYQDCNATASSSEVSDPLEKDDYNWLDMVHWSNFLAYAPPLPHIQDQFQSPVPGLTFAVNISAGY 352
                                             |..|...:.:..|..:....||.     ..||
 Frog   363 ---------------------------------FDHYGRRVNYTMDVLELKSNGLR-----KIGY 389

  Fly   353 YSSEHEAKTDLAAWSSVGEMRLL-------NETISPARRFFRIGTAESIPWSYLRREEGTGELIR 410
                         |:.:.::.||       |::.....|...:.|....|:...::..   ||:
 Frog   390 -------------WNDMDKLVLLQHEPAFKNDSSGIENRTVIVTTILEAPYVMYKKNH---ELL- 437

  Fly   411 DRSGLPIWEGYCIDFIIRLSQKLNFEFEI-VAPEVGHMGELNELGEWDGVVGDLVRGETDFAIAA 474
              .|...:||||:|....:::.:..:::| :.|:..:....:|...|:|:||:||.|:.:.|:|.
 Frog   438 --EGNDKFEGYCVDLAYEIAKHIGIKYKIAIVPDGKYGARDSETKIWNGMVGELVYGKAEIAVAP 500

  Fly   475 LKMYSEREEVIDFLPPYYEQTGISIAIRKPVR-RTSLFKFMTVLRLEVWLSIVAALVGTAIMIWF 538
            |.:...|||||||..|:. ..||||.|:||.: :..:|.|:..|..|:|:.||.|.:|.:::::.
 Frog   501 LTITLVREEVIDFSKPFM-SLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFL 564

  Fly   539 MDKYSPY--------SSRNNRQAYPYACREFTLRESFWFALTSFTPQGGGEAPKAISGRMLVAAY 595
            :.::|||        ..:......|  ..||.:..|.||:|.:|..||...:|:::|||::...:
 Frog   565 VSRFSPYEWHTEEPEDGKEGPSDQP--PNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVW 627

  Fly   596 WLFVVLMLATFTANLAAFLTVERMQTPVQSLEQLARQSRINYTVVKDSDTHQYFVNMKFAEDTLY 660
            |.|.:::::::|||||||||||||.:|::|.|.||:|:.|.|..:....|.::|...|.|   :|
 Frog   628 WFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDAGSTKEFFKRSKIA---VY 689

  Fly   661 RMWKELALNASKDFKKFRIWDYPIKEQYGHILLAINSSQPVADAK---EGFANVDAHENADYAFI 722
            .                ::|.|            :.|::|....|   ||.|.| ......:||:
 Frog   690 E----------------KMWTY------------MKSAEPSVFTKTTAEGVARV-RKSKGKFAFL 725

  Fly   723 HDSAEIKY-EITRNCNLTEVGEVFAEQPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYWN 786
            .:|...:| |..:.|:..:||.....:.|.||..:.|.|.:.::.|:|:|.:....::||.|:|.
 Frog   726 LESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKHSQLRNAVNLAVLKLNEQGLLDKLKNKWWY 790

  Fly   787 QSNLPNCPL----SEDQ-EGITLESLGGVFIATLFGLVLAMMTLGMEVLYYKKKQ-NALEIT--- 842
            ...  .|..    |:|: ..::|.::.|||...:.||.|||:...:|..|..:.: ..:::|
 Frog   791 DKG--ECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKLTFSE 853

  Fly   843 QVR-----PVNDSSGSGGNSSTAP-PTATST 867
            .:|     .:..|.|..|...|.. |.|..|
 Frog   854 AIRNKARLSITGSIGENGRVLTPDCPKAVHT 884

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	121/416 (29%)
gria4	XP_031751480.1	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611	60/347 (17%)
		PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	122/423 (29%)