Protein Alignment Ir8a and grin2ca

DIOPT Version :9

• Sequence 1: NP_727328.1
• Gene: Ir8a / 31867
• FlyBaseID: FBgn0052704
• Length: 936
• Species: Drosophila melanogaster
• Sequence 2: NP_001352716.1
• Gene: grin2ca / 100003342
• ZFINID: ZDB-GENE-070822-3
• Length: 1400
• Species: Danio rerio
• Alignment Length: 1140
• Identity: 226/1140 - (19%)
• Similarity: 377/1140 - (33%)
• Gaps: 382/1140 - (33%)

  Fly     3 LPLLVLL---------------------LALRFAGSEVLKITFWIEPVQRAEFDTDIAMVLKELD 46
            ||:|:||                     :|:.|:||               .:.|:|...|...:
Zfish    14 LPVLLLLSVCSVPCCQCRPFGMVEPTVNVAVVFSGS---------------AYQTEIKGRLSREN 63

  Fly    47 ALRLDVKVDDTTLTLTRSEDGLDMQRFCEILS-----------TVGASAVIDL------------ 88
            .|.|.::|:..|:.:..:.....:.|.|:.|:           .:|:.||..:
Zfish    64 FLDLPLEVNPITVLVNNTNPRTLLTRICDTLAANRVHGVVFEDNIGSEAVAQILDFISTQTAVPI 128

  Fly    89 ---------TYSHWEEG-----------------------YN-----LVRSLGIGYVRLERIMRP 116
                     ...|..:|                       ||     :|.||..||......:|.
Zfish   129 VGISGGSAVVLPHKGDGSTFLQLGSSIEQQINGMFKVMEEYNWDSFVVVTSLYPGYDTYVDYIRS 193

  Fly   117 FL---------------DMFGDFMRQKRANNVAMVFMNARDAVEAMQQMLVGYPFRTLIMDASQT 166
            |:               ||..|.|...||..:    :...||     |:|:.|         ...
Zfish   194 FIDTSYFLWELQDTLTFDMSADGMNDLRARRL----LQQIDA-----QVLLVY---------CSH 240

  Fly   167 DPGQHFLERIRSL-RPAPTYIALFARAAAMNGIFEKVQKADLFQRPL------EWHFVFLDTRDR 224
            |..|:.....|.: ...|.||......|..|   ..:...|.|...|      .|.   :..|:|
Zfish   241 DEAQYLFSMAREVGLVGPGYIWFIPSLAVGN---PNIAPPDSFPVGLISIITDRWK---MSLRNR 299

  Fly   225 -----------VFKYRRQAELCTRFTLNPRAICRSMPMPDLYCGSGFTMQRAMLLNVLRSLINAA 278
                       |..:|:|    ..|..:....|.|...|    .|..|:.|.| |||.....:.:
Zfish   300 VRDGVAIVVKGVESFRKQ----RGFIPDGHMDCLSPIRP----ASNGTLYRHM-LNVSWENTDFS 355

  Fly   279 QVSPGY---PLAIYQDCNATASSSEVSDPLEKDDYNWLDMVH--WSNFLAYAPPL---------- 328
            ..|.||   |..|.    .|.......|.:...:...|.|.:  |..:..:..|:
Zfish   356 FNSDGYLVNPSMII----ITLDRGRQWDKVGNYESGILQMRYPVWPRYGTFLEPVSDNRHLTVAT 416

  Fly   329 ----PHIQDQFQSPVPGLTFAVNISAGYYSSEHEAKTDLAAWSSVGEMRLLNETISPARRFFRIG 389
                |.:..:...||.|...:..:.....|::                   .|||        :|
Zfish   417 LEERPFVIVEAVDPVTGTCLSNTVPCRRQSNK-------------------TETI--------VG 454

  Fly   390 TAESIPWSYLRREEGTGELIRDRSGLPIWEGYCIDFIIRLSQKLNFEFEIVAPEVGHMGELNELG 454
            ..|  |::.|                 ..:|:|||.:.:||:.:.|.:::.....|..|:|.. |
Zfish   455 HTE--PYTKL-----------------CCKGFCIDILKKLSRNIKFSYDLYLVTNGKHGKLVR-G 499

  Fly   455 EWDGVVGDLVRGETDFAIAALKMYSEREEVIDFLPPYYEQTGISIAIRKPVRRTSLFKFMTVLRL 519
            .|:|::|::.....|.||.:|.:..||.|:|||..|:.| ||||:.:.:.....|...|:.....
Zfish   500 IWNGMIGEVFYKRADMAIGSLTINEERSEIIDFSVPFVE-TGISVMVARSNGTVSPSAFLEPYSP 563

  Fly   520 EVW-LSIVAALVGTAIMIWFMDKYSPYS-SRNNRQAYPYACREFTLRESFW----FALTSFTPQG 578
            .|| :..|..|...|:.::..:..||.. :|:...|.......||:.:|.|    ....:..|.
Zfish   564 AVWVMMFVMCLTVVAVTVFVFEYCSPVGYNRSLVSAKDPGGPTFTIGKSVWLLWGIVFNNSVPI- 627

  Fly   579 GGEAPKAISGRMLVAAYWLFVVLMLATFTANLAAFLTVERMQTPVQSLE---------------- 627
              |.||..:.:::|..:..|.|:.||::|||||||:..|:....|..|.
Zfish   628 --ENPKGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQKPQDQYPPFRF 690

  Fly   628 ------QLARQSRINYTVVKDSDTHQYFVNMKFAEDTLYRMWKELALNASKDFKKFRIWDYPIKE 686
                  ...|..|.||   .:..:|....|.|..||         |||:.|..|
Zfish   691 GTVPNGSTERNIRSNY---PEMHSHMVKYNQKGVED---------ALNSLKTGK----------- 732

  Fly   687 QYGHILLAINSSQPVADAKEGFANVDAHENADYAFIHDSAEIKYEITRN--CNLTEV--GEVFAE 747
                                    :|       |||:|:|.:.|...::  |.|..:  |:|||.
Zfish   733 ------------------------LD-------AFIYDAAVLNYMAGKDEGCKLVTIGSGKVFAT 766

  Fly   748 QPYAVAVQQGSHLGDELSYAILELQKDRFFEELKAKYWNQSNLPNCPLSEDQE----GITLESLG 808
            ..|.:|:|:.|.....:..|:|:...|...::|:. .|    |.....:|.:|    .:.::::.
Zfish   767 TGYGIALQKESRWKRPIDLALLQFLADGDTQKLQT-VW----LTGICRNEKKEVMSSKLDIDNMA 826

  Fly   809 GVFIATLFGLVLAMMTLGMEVLYYKKKQNALEITQ---------------VRPVNDSSGSGGNSS 858
            |||...|..:.|:::....|.|.|.|.::::..::               ...|.|:...|...:
Zfish   827 GVFYMLLVAMGLSLLVFAWEHLLYWKLRHSVRKSERLDFLLAISRGIYSCFNGVEDTDRKGNMQN 891

  Fly   859 TAPPTATSTTKQAWHIPVLEA---------------------------EEKPAKVSPPPSFETAT 896
               |..|::..||..:.:|:.                           :.:..:.|.||......
Zfish   892 ---PDVTTSYTQANMLKMLQTAKDIVSSARVENSLDNATKTIENWSRRDPESGRTSLPPCLIGTD 953

  Fly   897 FRGKKLPARITLGDGKFKPRHGLYARRNLGASDSH 931
            |...:||...::.|     .|..|. :|:.::..|
Zfish   954 FSHGRLPCIASVTD-----NHSPYP-QNVDSTTQH 982

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir8a	NP_727328.1	PBP2_iGluR_putative	383..786	CDD:270435	103/434 (24%)
		Lig_chan	520..818	CDD:278489	75/333 (23%)
grin2ca	NP_001352716.1	PBP1_iGluR_NMDA_NR2	38..398	CDD:107373	77/411 (19%)
		PBP2_iGluR_NMDA_Nr2	409..810	CDD:270436	113/510 (22%)
		NMDAR2_C	847..>938	CDD:313729	11/93 (12%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900