DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31296 and CRISPLD2

DIOPT Version :9

Sequence 1:	NP_001262608.1	Gene:	CG31296 / 318668	FlyBaseID:	FBgn0051296	Length:	280	Species:	Drosophila melanogaster
Sequence 2:	NP_113664.1	Gene:	CRISPLD2 / 83716	HGNCID:	25248	Length:	497	Species:	Homo sapiens

Alignment Length:	311	Identity:	59/311 - (18%)
Similarity:	91/311 - (29%)	Gaps:	109/311 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 IPFGCSKLVDFCQLPYCGTNNLACNNPSKFSVMCPPNARTLSMSTYRNL--------LLIAFNEF 71
            ||.|...||       ||:......|.:....:........|.|..|..        :|:..|:.
Human     9 IPLGLLFLV-------CGSQGYLLPNVTLLEELLSKYQHNESHSRVRRAIPREDKEEILMLHNKL 66

  Fly    72 RNYTASGKQKYLKAAAARMSRLSYSMELEDLARLAVITCS-THKFCLNSQEFYYVGTNIGSTHYL 135
            |.        .::..|:.|..:::..|||..|......|. .|.   .:.....:|.|:|:
Human    67 RG--------QVQPQASNMEYMTWDDELEKSAAAWASQCIWEHG---PTSLLVSIGQNLGA---- 116

  Fly   136 GNLNDYEDLELMLRIIQHWTRYAD--------YVNIKMGVY-MPTTL---------GKSGIAKAL 182
                             ||.||..        |..:|...| .|:..         |........
Human   117 -----------------HWGRYRSPGFHVQSWYDEVKDYTYPYPSECNPWCPERCSGPMCTHYTQ 164

  Fly   183 LLMADRNTHVGC---SAMRFTV------HSVHNFVFLCAFST--DLFVERPIYRMSMRPGAACKR 236
            ::.|..| .:||   :..:.||      ::|:   |:|.:|.  :...|.|     .:.|..|..
Human   165 IVWATTN-KIGCAVNTCRKMTVWGEVWENAVY---FVCNYSPKGNWIGEAP-----YKNGRPCSE 220

  Fly   237 LDPTYSA-----LCAVGENY------------------ENNKPMLNARVFQ 264
            ..|:|..     ||...|.|                  |.|...|..||.:
Human   221 CPPSYGGSCRNNLCYREETYTPKPETDEMNEVETAPIPEENHVWLQPRVMR 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31296	NP_001262608.1	SCP_euk	61..214	CDD:240180	33/188 (18%)
CRISPLD2	NP_113664.1	SCP_euk	56..201	CDD:240180	32/180 (18%)
		LCCL	286..370	CDD:128866
		LCCL	387..479	CDD:128866
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2340
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1528782at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10334
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920