Protein Alignment CG31294 and TTC12

DIOPT Version :10

• Sequence 1: NP_732055.1
• Gene: CG31294 / 318666
• FlyBaseID: FBgn0051294
• Length: 225
• Species: Drosophila melanogaster
• Sequence 2: NP_001305462.1
• Gene: TTC12 / 54970
• HGNCID: 23700
• Length: 711
• Species: Homo sapiens
• Alignment Length: 214
• Identity: 58/214 - (27%)
• Similarity: 95/214 - (44%)
• Gaps: 39/214 - (18%)

  Fly     1 MDADESFLNQRSLLMDVMKQLED-------LQNANKMDTGTKGK----EEKK---PEVDPSEG-- 49
            ||||:.        .|:.|.|::       :|..|..|...:.|    .||:   .|.|..|.
Human     1 MDADKE--------KDLQKFLKNVDEISNLIQEMNSDDPVVQQKAVLETEKRLLLMEEDQEEDEC 57

  Fly    50 -VTITNFMVFARDVRKKSSRYLKRVQKMSNINQISFMRQIDVSPKDRAEARRDREIVADSFRRLG 113
             .|:...|:.......||:         ..||..:|:..::...|:||:.||:.:::||:.:..|
Human    58 RTTLNKTMISPPQTAMKSA---------EEINSEAFLASVEKDAKERAKRRRENKVLADALKEKG 113

  Fly   114 NEEYRRTNYEKAVYFYSKAIQYVADSPVLYCNRALAKIKKRDFKLALFDLDYVI-----FNLDPI 173
            ||.:...|||.|:..||:.::.:.|..|||.|||.|.:|..|::.||.|.::.:     ...|..
Human   114 NEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKSFSFMQCDEK 178

  Fly   174 HLRAWLYRAGALARLNNES 192
            ..:|:.:...|...|.|.|
Human   179 CTKAYFHMGKANLALKNYS 197

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31294	NP_732055.1	NlpI	<106..>199	CDD:443815	30/92 (33%)
		TPR repeat	106..134	CDD:276809	11/27 (41%)
		TPR repeat	139..170	CDD:276809	12/35 (34%)
TTC12	NP_001305462.1	TPR	105..>212	CDD:440225	30/93 (32%)
		TPR 1	106..139		11/32 (34%)
		TPR repeat	106..134	CDD:276809	11/27 (41%)
		TPR repeat	139..175	CDD:276809	12/35 (34%)
		TPR 3	180..213		5/18 (28%)
		TPR repeat	180..208	CDD:276809	5/18 (28%)
		TPR repeat	217..242	CDD:276809
		armadillo repeat	561..597	CDD:293788
		armadillo repeat	603..637	CDD:293788