Protein Alignment CG31294 and STUB1

DIOPT Version :10

• Sequence 1: NP_732055.1
• Gene: CG31294 / 318666
• FlyBaseID: FBgn0051294
• Length: 225
• Species: Drosophila melanogaster
• Sequence 2: NP_005852.2
• Gene: STUB1 / 10273
• HGNCID: 11427
• Length: 303
• Species: Homo sapiens
• Alignment Length: 108
• Identity: 29/108 - (26%)
• Similarity: 47/108 - (43%)
• Gaps: 6/108 - (5%)

  Fly   106 ADSFRRLGNEEYRRTNYEKAVYFYSKAIQYVADSPVLYCNRALAKIKKRDFKLALFDLDYVIFNL 170
            |...:..||..:....|.:|...|.:||.......|.|.||||..:|.:..:.||.|....: .|
Human    26 AQELKEQGNRLFVGRKYPEAAACYGRAITRNPLVAVYYTNRALCYLKMQQHEQALADCRRAL-EL 89

  Fly   171 DPIHLRAWLYRAGALARLNNESE-FEIAIANARLLNRSQKDKK 212
            |...::|..:    |.:...|.| ::.||||.:......|:::
Human    90 DGQSVKAHFF----LGQCQLEMESYDEAIANLQRAYSLAKEQR 128

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31294	NP_732055.1	NlpI	<106..>199	CDD:443815	25/93 (27%)
		TPR repeat	106..134	CDD:276809	7/27 (26%)
		TPR repeat	139..170	CDD:276809	10/30 (33%)
STUB1	NP_005852.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30		1/3 (33%)
		Spy	25..>124	CDD:443119	28/102 (27%)
		TPR 1	26..59		8/32 (25%)
		TPR repeat	26..54	CDD:276809	7/27 (26%)
		TPR repeat	59..89	CDD:276809	10/30 (33%)
		TPR 2	60..93		12/33 (36%)
		TPR repeat	94..122	CDD:276809	8/31 (26%)
		TPR 3	95..127		9/35 (26%)
		Required for interaction with MAPK7. /evidence=ECO:0000269|PubMed:20724525	101..200		7/28 (25%)
		CHIP_TPR_N	142..225	CDD:436460
		Required for interaction with and ubiquitination of MYOCD. /evidence=ECO:0000250|UniProtKB:A6HD62	142..196
		Required for ubiquitination of FOXO1. /evidence=ECO:0000269|PubMed:19483080	143..303
		Required for interaction with FOXO1. /evidence=ECO:0000269|PubMed:19483080	143..197
		RING-Ubox_CHIP	227..297	CDD:438316