DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12121 and Gpr108

DIOPT Version :9

Sequence 1:	NP_572545.1	Gene:	CG12121 / 31866	FlyBaseID:	FBgn0030109	Length:	738	Species:	Drosophila melanogaster
Sequence 2:	NP_084360.2	Gene:	Gpr108 / 78308	MGIID:	1925558	Length:	569	Species:	Mus musculus

Alignment Length:	699	Identity:	245/699 - (35%)
Similarity:	353/699 - (50%)	Gaps:	166/699 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 TALLWAPLEVL--------GRKHHLEVRNDRRQYIALSTFGFYTNGHLDVQLSKLTF---DNEQS 71
            |...|..|.:|        ||.|.|.:..::|..|.|::|||||||.|:|:||.|..   :.|:.
Mouse    15 TQCRWGYLSLLVLTLSGCSGRIHRLTLTGEKRADIQLNSFGFYTNGSLEVELSLLRLSLQETEKK 79

  Fly    72 TDLMGLSLDKTTIDQLNPYLDSHQNKCILEESPKSQISGPILFFVLDLKELKVRVKCSPEWHNMH 136
            ...:|.||.:.....:..|...:.::|.|:.:.    |..::.|::::|:|:|:|:
Mouse    80 LPKVGFSLSRVRSGSVRSYSRRNSHECPLDRNS----SNFLVLFLINIKDLQVQVR--------- 131

  Fly   137 IYNQIPSRTKRHSHMAKVSDSVLFRQTRAAQDFSAEGPDESMEDPLEQEPTDLKSSSPAAVAGKI 201
                            |..:..||                               .||..:.
Mouse   132 ----------------KYGEQKLF-------------------------------ISPGLLP--- 146

  Fly   202 ELPKDEGAPKVDAPAQNVDAVKEESVPKPEVAANQNISDKQELPPPPNAAPKVEEAVKSEQKQEE 266
            |.|...|.||.| ||         ..||          |...:.|.|...    .|||..|...:
Mouse   147 EAPTQSGPPKPD-PA---------GTPK----------DNHVIHPSPTEM----SAVKENQTAPQ 187

  Fly   267 APAEKDETPSKKEETPAKQVSVEEPKVAAPPLAVNSPAAAPSLDDTEVDKKNEATDTDAAPGNPF 331
            ...:| .||.:...:..:|...::|                           ...:.|...|  .
Mouse   188 VSGDK-TTPGEHRHSSERQPPTQDP---------------------------SGKEKDQVLG--L 222

  Fly   332 PHEGDSEEDSYGPDSFKQSQENLCKDSTMPLVRETINNVHYYSFNFSMMVATPSDEGLYNLYFHA 396
            .|..||                                   |:|:|.:::::.::||.|:|.||.
Mouse   223 GHLNDS-----------------------------------YNFSFHIVISSRAEEGQYSLNFHN 252

  Fly   397 CPNYHTSKIMSFN--VDIEENNNGNYLSAGEMPLPALYFMMSLLFFLSGLFWVFILKKSKHTVYK 459
            |.|....:...|:  |.|.|.|...:|||.|:||..||.:||..|..:.:|||.:|.|:.::|:|
Mouse   253 CHNSIPGQEQPFDLTVMIREKNPEGFLSAAEIPLFKLYLIMSACFLAADIFWVSVLCKNTYSVFK 317

  Fly   460 IHYLMAVLVFLKSLSLMFHSINYHFIEKRGEHVETWAILYYIAHLLKGAVLFITIVLIGTGWTFI 524
            ||:|||.|.|.||:||:||||||:||..:|..:|..|:::||.||||||:|||||.|||:||.|:
Mouse   318 IHWLMAALAFTKSVSLLFHSINYYFINSQGHPIEGLAVMHYITHLLKGALLFITIALIGSGWAFV 382

  Fly   525 KHILSDKDKKIFMIVIPLQVLANVAQIITDESDQSDAEFRTWHNIFFFVDLLCCGAILFPIVWSI 589
            |::||||:||||.||||||||||||.|:.:..::..:::..|..|.|.|||:||||||||:||||
Mouse   383 KYMLSDKEKKIFGIVIPLQVLANVAYIVIESREEGASDYGLWKEILFLVDLICCGAILFPVVWSI 447

  Fly   590 RHLHEASATDGKAAINLRKLKLFRQFYIMIVCYIYFTRIIVDLLQMTVVFQYAWLDEMFREMATY 654
            |||.:||.||||.|:||.:|||||.:|:|::|||||||||..|||:.|.||:.||.::..|.:|.
Mouse   448 RHLQDASGTDGKVAVNLARLKLFRHYYVMVICYIYFTRIIAILLQVAVPFQWQWLYQLLVESSTL 512

  Fly   655 VFFVLTGYKFRPVSSHPYFTVPDEDEDDDEVE-VLTESGLTETVHRVKQ 702
            .|||||||||:|...:||..:|.|||:|.::| |:|:||..|.:.:|.:
Mouse   513 AFFVLTGYKFQPAGDNPYLQLPQEDEEDVQMEQVMTDSGFREGLSKVNK 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12121	NP_572545.1	Spore_coat_CotO	194..>290	CDD:290858	22/95 (23%)
		Neuromodulin	195..353	CDD:284117	27/157 (17%)
		Lung_7-TM_R	387..671	CDD:284280	160/285 (56%)
Gpr108	NP_084360.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	144..219		23/129 (18%)
Gpr108	NP_084360.2	Lung_7-TM_R	241..529	CDD:284280	160/287 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833550
Domainoid	1	1.000	380	1.000	Domainoid score	I843
eggNOG	1	0.900	-	-		E1_KOG2569
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	431	1.000	Inparanoid score	I1712
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003576
OrthoInspector	1	1.000	-	-		otm43123
orthoMCL	1	0.900	-	-		OOG6_103663
Panther	1	1.100	-	-	O	PTHR21229
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5824
SonicParanoid	1	1.000	-	-		X1558
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.780