Protein Alignment CG12121 and GPR108

DIOPT Version :10

• Sequence 1: NP_572545.1
• Gene: CG12121 / 31866
• FlyBaseID: FBgn0030109
• Length: 738
• Species: Drosophila melanogaster
• Sequence 2: NP_001381646.1
• Gene: GPR108 / 56927
• HGNCID: 17829
• Length: 634
• Species: Homo sapiens
• Alignment Length: 563
• Identity: 174/563 - (30%)
• Similarity: 254/563 - (45%)
• Gaps: 181/563 - (32%)

  Fly    29 GRKHHLEVRNDRRQYIALSTFGFYTNGHLDVQLSKLTF---DNEQSTDLMGLSLDKTTIDQLNPY 90
            ||.|.|.:..::|..|.|::|||||||.|:|:||.|..   :.|:.:.|:|.||.:....::..|
Human    32 GRIHQLALTGEKRADIQLNSFGFYTNGSLEVELSVLRLGLREAEEKSLLVGFSLSRVRSGRVRSY 96

  Fly    91 LDSHQNKCILEESPKSQISGPILFFVLDLKELKVRVKCSPEWHNMHIYNQIPSRTKRHSHMAKVS 155
            .......|.|:::..|.    ::.|:::.|:|:|:|:...|...:.|:
Human    97 STRDFQDCPLQKNSSSF----LVLFLINTKDLQVQVRKYGEQKTLFIF----------------- 140

  Fly   156 DSVLFRQTRAAQDFSAEGPDESMEDPLEQEPTDLKSSSPAAVAGKIELPKDEGAPKVDAPAQNVD 220
                                                  |..:.   |.|...|.||..|
Human   141 --------------------------------------PGLLP---EAPSKPGLPKPQA------ 158

  Fly   221 AVKEESVPKPEVAANQNISDKQELPPPPNAAPKVEEAVKSEQKQEEAPAEKDETPSKKEETPAKQ 285
                 :||:                       ||:....|             ..||.:.|||
Human   159 -----TVPR-----------------------KVDGGGTS-------------AASKPKSTPA-- 180

  Fly   286 VSVEEPKVAAPPLAVNSPAAAPSLDDTEVDKKNEATDTDAAPGNPFPHEGDSEEDSYGPDSFKQS 350
                         .:..|:.
Human   181 -------------VIQGPSG--------------------------------------------- 187

  Fly   351 QENLCKDSTMPLVRETINNVHYYSFNFSMMVATPSDEGLYNLYFHACPNYHTSKIMSFNVD--IE 413
                 ||..:.|....:||  .|:|:|.:::.:.::||.|:|.||.|.|....|...|::.  |.
Human   188 -----KDKDLVLGLSHLNN--SYNFSFHVVIGSQAEEGQYSLNFHNCNNSVPGKEHPFDITVMIR 245

  Fly   414 ENNNGNYLSAGEMPLPALYFMMSLLFFLSGLFWVFILKKSKHTVYKIHYLMAVLVFLKSLSLMFH 478
            |.|...:|||.||||..||.:||..|..:|:|||.||.::.::|:|||:|||.|.|.||:||:||
Human   246 EKNPDGFLSAAEMPLFKLYMVMSACFLAAGIFWVSILCRNTYSVFKIHWLMAALAFTKSISLLFH 310

  Fly   479 SINYHFIEKRGEHVETWAILYYIAHLLKGAVLFITIVLIGTGWTFIKHILSDKDKKIFMIVIPLQ 543
            ||||:||..:|..:|..|::||||||||||:|||||.|||:||.|||::||||:||:|.||||:|
Human   311 SINYYFINSQGHPIEGLAVMYYIAHLLKGALLFITIALIGSGWAFIKYVLSDKEKKVFGIVIPMQ 375

  Fly   544 VLANVAQIITDESDQSDAEFRTWHNIFFFVDLLCCGAILFPIV 586
            ||||||.||.:..::..:::..|..|.|.|||:||||||||:|
Human   376 VLANVAYIIIESREEGASDYVLWKEILFLVDLICCGAILFPVV 418

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12121	NP_572545.1	LGT	<179..345	CDD:469786	18/165 (11%)
		Lung_7-TM_R	387..671	CDD:369089	113/202 (56%)
GPR108	NP_001381646.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	149..186		14/98 (14%)
		Lung_7-TM_R	216..>418	CDD:473945	112/201 (56%)