DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12121 and GPR108

DIOPT Version :9

Sequence 1:	NP_572545.1	Gene:	CG12121 / 31866	FlyBaseID:	FBgn0030109	Length:	738	Species:	Drosophila melanogaster
Sequence 2:	NP_001381646.1	Gene:	GPR108 / 56927	HGNCID:	17829	Length:	634	Species:	Homo sapiens

Alignment Length:	563	Identity:	174/563 - (30%)
Similarity:	254/563 - (45%)	Gaps:	181/563 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 GRKHHLEVRNDRRQYIALSTFGFYTNGHLDVQLSKLTF---DNEQSTDLMGLSLDKTTIDQLNPY 90
            ||.|.|.:..::|..|.|::|||||||.|:|:||.|..   :.|:.:.|:|.||.:....::..|
Human    32 GRIHQLALTGEKRADIQLNSFGFYTNGSLEVELSVLRLGLREAEEKSLLVGFSLSRVRSGRVRSY 96

  Fly    91 LDSHQNKCILEESPKSQISGPILFFVLDLKELKVRVKCSPEWHNMHIYNQIPSRTKRHSHMAKVS 155
            .......|.|:::..|.    ::.|:::.|:|:|:|:...|...:.|:
Human    97 STRDFQDCPLQKNSSSF----LVLFLINTKDLQVQVRKYGEQKTLFIF----------------- 140

  Fly   156 DSVLFRQTRAAQDFSAEGPDESMEDPLEQEPTDLKSSSPAAVAGKIELPKDEGAPKVDAPAQNVD 220
                                                  |..:.   |.|...|.||..|
Human   141 --------------------------------------PGLLP---EAPSKPGLPKPQA------ 158

  Fly   221 AVKEESVPKPEVAANQNISDKQELPPPPNAAPKVEEAVKSEQKQEEAPAEKDETPSKKEETPAKQ 285
                 :||:                       ||:....|             ..||.:.|||
Human   159 -----TVPR-----------------------KVDGGGTS-------------AASKPKSTPA-- 180

  Fly   286 VSVEEPKVAAPPLAVNSPAAAPSLDDTEVDKKNEATDTDAAPGNPFPHEGDSEEDSYGPDSFKQS 350
                         .:..|:.
Human   181 -------------VIQGPSG--------------------------------------------- 187

  Fly   351 QENLCKDSTMPLVRETINNVHYYSFNFSMMVATPSDEGLYNLYFHACPNYHTSKIMSFNVD--IE 413
                 ||..:.|....:||  .|:|:|.:::.:.::||.|:|.||.|.|....|...|::.  |.
Human   188 -----KDKDLVLGLSHLNN--SYNFSFHVVIGSQAEEGQYSLNFHNCNNSVPGKEHPFDITVMIR 245

  Fly   414 ENNNGNYLSAGEMPLPALYFMMSLLFFLSGLFWVFILKKSKHTVYKIHYLMAVLVFLKSLSLMFH 478
            |.|...:|||.||||..||.:||..|..:|:|||.||.::.::|:|||:|||.|.|.||:||:||
Human   246 EKNPDGFLSAAEMPLFKLYMVMSACFLAAGIFWVSILCRNTYSVFKIHWLMAALAFTKSISLLFH 310

  Fly   479 SINYHFIEKRGEHVETWAILYYIAHLLKGAVLFITIVLIGTGWTFIKHILSDKDKKIFMIVIPLQ 543
            ||||:||..:|..:|..|::||||||||||:|||||.|||:||.|||::||||:||:|.||||:|
Human   311 SINYYFINSQGHPIEGLAVMYYIAHLLKGALLFITIALIGSGWAFIKYVLSDKEKKVFGIVIPMQ 375

  Fly   544 VLANVAQIITDESDQSDAEFRTWHNIFFFVDLLCCGAILFPIV 586
            ||||||.||.:..::..:::..|..|.|.|||:||||||||:|
Human   376 VLANVAYIIIESREEGASDYVLWKEILFLVDLICCGAILFPVV 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12121	NP_572545.1	Spore_coat_CotO	194..>290	CDD:290858	17/95 (18%)
		Neuromodulin	195..353	CDD:284117	17/157 (11%)
		Lung_7-TM_R	387..671	CDD:284280	113/202 (56%)
GPR108	NP_001381646.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	149..186		14/98 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143382
Domainoid	1	1.000	345	1.000	Domainoid score	I1049
eggNOG	1	0.900	-	-		E1_KOG2569
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	443	1.000	Inparanoid score	I1656
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1427067at2759
OrthoFinder	1	1.000	-	-		FOG0003576
OrthoInspector	1	1.000	-	-		otm41052
orthoMCL	1	0.900	-	-		OOG6_103663
Panther	1	1.100	-	-	O	PTHR21229
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5824
SonicParanoid	1	1.000	-	-		X1558
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790