DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12121 and TMEM87A

DIOPT Version :9

Sequence 1:	NP_572545.1	Gene:	CG12121 / 31866	FlyBaseID:	FBgn0030109	Length:	738	Species:	Drosophila melanogaster
Sequence 2:	XP_005254344.1	Gene:	TMEM87A / 25963	HGNCID:	24522	Length:	556	Species:	Homo sapiens

Alignment Length:	379	Identity:	71/379 - (18%)
Similarity:	146/379 - (38%)	Gaps:	83/379 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   408 FNVDIEENNNGNYLSAGEMPLPALYFMMSLLFFLSGLFWVFILKKSKHTVYKIHYLMAVLVFLKS 472
            |.:.:|......||:..:.||...:.:|.:::.|.|:.|:.........:.:|.:.:..::||..
Human   206 FTMTVEVKGPYEYLTLEDYPLMIFFMVMCIVYVLFGVLWLAWSACYWRDLLRIQFWIGAVIFLGM 270

  Fly   473 LSLMFHSINYHFIEKRGEHVETWAILYYIAHLLKGAVLFITIVLIGTGWTFIKHILSDKDKKIFM 537
            |........:..|..:||.|:...||..:...:|.::....::::..|:..:|..|.....|:.:
Human   271 LEKAVFYAEFQNIRYKGESVQGALILAELLSAVKRSLARTLVIIVSLGYGIVKPRLGVTLHKVVV 335

  Fly   538 --------------------IVIPLQVLANVAQIITDESDQSDAEFRTWHNIFFFVDLLCCGAIL 582
                                ...||.::.|:|      ....||....|    .|:.|.....:|
Human   336 AGALYLLFSGMEGVLRVTGYFSYPLTLIVNLA------LSAIDACVILW----IFISLTQTMKLL 390

  Fly   583 FPIVWSIRHLHEASATDGKAAINLRKLKLFRQFYIMIVCYIYFTRIIVDLLQMTVVFQYA----- 642
                              |...|:.||.|:|.|...::..:  ...||.::..|:.|:..
Human   391 ------------------KLRRNIVKLSLYRHFTNTLILAV--AASIVFIIWTTMKFRIVTCQSD 435

  Fly   643 ----WLDE-MFREMATYVFFVLTGYKFRPVSSHPYFT---VPDEDEDDDEVE-VLTES--GL--- 693
                |:|: ::|.:.:.:.||:. ..:||.:::..|.   :.:|:|:|::.| :|.||  |:
Human   436 WRELWVDDAIWRLLFSMILFVIM-VLWRPSANNQRFAFSPLSEEEEEDEQKEPMLKESFEGMKMR 499

  Fly   694 --------TETVHR-----VKQLNRNHGSGLGGITIIEGNDDERENLIAKRESS 734
                    ...|::     :|.:..|..|.:..:.:....|.:.|.:|...|.|
Human   500 STKQEPNGNSKVNKAQEDDLKWVEENVPSSVTDVALPALLDSDEERMITHFERS 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12121	NP_572545.1	Spore_coat_CotO	194..>290	CDD:290858
		Neuromodulin	195..353	CDD:284117
		Lung_7-TM_R	387..671	CDD:284280	53/292 (18%)
TMEM87A	XP_005254344.1	Lung_7-TM_R	206..468	CDD:284280	53/292 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143387
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840