DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31274 and alh-3

DIOPT Version :9

Sequence 1:	NP_732186.1	Gene:	CG31274 / 318655	FlyBaseID:	FBgn0051274	Length:	280	Species:	Drosophila melanogaster
Sequence 2:	NP_502054.2	Gene:	alh-3 / 177999	WormBaseID:	WBGene00000109	Length:	908	Species:	Caenorhabditis elegans

Alignment Length:	323	Identity:	59/323 - (18%)
Similarity:	104/323 - (32%)	Gaps:	115/323 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 CL---TEVLRNCANIQSLESLNYEYNDVLL------------TEDNVGKMITPNP----YSFSGN 65
            ||   ..|:...|.:..|.:|.:....||.            :...||..:|.:|    ..|:|:
Worm   593 CLAAGNTVVHKPAQVTPLTALKFAELSVLAGIPPGVINIVTGSGSLVGNRLTAHPDVRKIGFTGS 657

  Fly    66 ISISSCPSEDVSFSESILEDNGRISLAYENLKTIPRRLADKFAAQTKFLDLSHNDFRNLRFLSFF 130
            ..|.:          :::|     |.|..|:|.:...|..|..                  |..|
Worm   658 TEIGA----------TVME-----SCAKSNIKKVSLELGGKSP------------------LIIF 689

  Fly   131 EDLDTLILDRNVNLDINTFPYLPSLRILWIN---NCDIAN---ITDWIHR--IERHCPALDQLSC 187
            .|.|   |::.|.         .:...::.|   ||..|.   |...||.  :::......|..
Worm   690 ADAD---LEKAVK---------QACGAVFFNKGENCIAAGRVFIAKSIHDDFVKKLVEEAKQYQ- 741

  Fly   188 MGNPGIRTVFGGQGPREYILQVLPQLKYLD------------GLPTSRNAAY--ATLSSSQGQGP 238
            :|:|..|:.  ..||:.::..:...::|::            |....|...|  .|:.|:.....
Worm   742 IGDPLDRST--AHGPQNHLAHLNKLVEYVEKAVAGGAKVEVGGKRLEREGLYFPPTILSNIDDEN 804

  Fly   239 DSTSNSEKPPLASAFTF-----KDIIR--------------PKYSRKS-------HSGRMFGN 275
            .:.|.....|:....:|     :|::|              .:.|.||       |:|.:|.|
Worm   805 FAASEESFGPIMCVSSFDDDDIEDVLRRANDTEFGLAAGVFTRDSSKSLRVAEALHAGTVFVN 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31274	NP_732186.1	leucine-rich repeat	111..132	CDD:275378	2/20 (10%)
		leucine-rich repeat	133..154	CDD:275378	3/20 (15%)
		leucine-rich repeat	155..181	CDD:275378	7/33 (21%)
alh-3	NP_502054.2	fmt	1..318	CDD:273088
		FMT_core_FDH_N	1..209	CDD:187716
		FDH_Hydrolase_C	214..315	CDD:187731
		PP-binding	335..393	CDD:278949
		ALDH-SF	423..908	CDD:299846	59/323 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900