DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31274 and ALDH1L2

DIOPT Version :9

Sequence 1:	NP_732186.1	Gene:	CG31274 / 318655	FlyBaseID:	FBgn0051274	Length:	280	Species:	Drosophila melanogaster
Sequence 2:	NP_001029345.2	Gene:	ALDH1L2 / 160428	HGNCID:	26777	Length:	923	Species:	Homo sapiens

Alignment Length:	153	Identity:	33/153 - (21%)
Similarity:	58/153 - (37%)	Gaps:	48/153 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 QSLESLNYEYNDVLLTEDNVGKMITPNPYSFSGNISISSCPSEDVSFSES-------------IL 83
            ::|...|.::.|        ||||..:.|..:|..|:....:|:|..:|:             |:
Human   306 KALTVRNLQFED--------GKMIPASQYFSTGETSVVELTAEEVKVAETIKVIWAGILSNVPII 362

  Fly    84 ED------NGRISLAYENLKTIPRRLADKFAAQTKFLDLSHND-FRNLRFLSFF---------ED 132
            ||      :|..|:..       .||.::...:...|.|.:.| :...:|..|.         ||
Human   363 EDSTDFFKSGASSMDV-------ARLVEEIRQKCGGLQLQNEDVYMATKFEGFIQKVVRKLRGED 420

  Fly   133 LDT-LILD---RNVNLDINTFPY 151
            .:. |::|   :.||..:...||
Human   421 QEVELVVDYISKEVNEIMVKMPY 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31274	NP_732186.1	leucine-rich repeat	111..132	CDD:275378	5/30 (17%)
		leucine-rich repeat	133..154	CDD:275378	6/23 (26%)
		leucine-rich repeat	155..181	CDD:275378
ALDH1L2	NP_001029345.2	Fmt	22..326	CDD:223301	7/27 (26%)
		FMT_core_FDH_N	23..225	CDD:187716
		GART	23..225
		FDH_Hydrolase_C	228..327	CDD:187731	7/28 (25%)
		PP-binding	346..>390	CDD:278949	8/50 (16%)
		Aldehyde dehydrogenase	438..923		2/6 (33%)
		ALDH_F1L_FTFDH	439..923	CDD:143458	2/5 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900