DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31269 and TMPRSS3

DIOPT Version :9

Sequence 1:	NP_001097818.1	Gene:	CG31269 / 318653	FlyBaseID:	FBgn0051269	Length:	273	Species:	Drosophila melanogaster
Sequence 2:	NP_076927.1	Gene:	TMPRSS3 / 64699	HGNCID:	11877	Length:	454	Species:	Homo sapiens

Alignment Length:	250	Identity:	87/250 - (34%)
Similarity:	122/250 - (48%)	Gaps:	34/250 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 RIIGGQAAEDGFAPYQISLQGISGAHSCGGAIINETFVLTAAHCVENAFIP--WLVVVTGTNKYN 99
            ||:||..:.....|:|.||| ..|.|.|||::|...:::||||||.:.::|  |.:.|...:..:
Human   216 RIVGGNMSLLSQWPWQASLQ-FQGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLD 279

  Fly   100 QPGGRYFLKAIHIHCNYDNPEMHNDIALLELVEPIAWDERTQPIPLPLVPMQ-PGDEVILT-GWG 162
            .|...:.::.|..|..|....:.|||||::|..|:.::|..||:.||..... |..:|..| |||
Human   280 NPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWG 344

  Fly   163 STV--LWGTSPIDLQVLYLQYVPHRECKALLSNDEDC---DV-GHICTFSRL-------GEGACH 214
            :|.  ....||    ||....||      |:|| :.|   || |.|.:.|.|       |..:|.
Human   345 ATEDGAGDASP----VLNHAAVP------LISN-KICNHRDVYGGIISPSMLCAGYLTGGVDSCQ 398

  Fly   215 GDSGGPLVSN----GYLVGLVNWGWPCA-TGVPDVHASVYFYRDWIRNVMSGNSK 264
            ||||||||..    ..|||..::|..|| ...|.|:..|..:.|||...|..:.|
Human   399 GDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQMERDLK 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31269	NP_001097818.1	Tryp_SPc	37..255	CDD:214473	83/239 (35%)
CG31269	NP_001097818.1	Tryp_SPc	38..258	CDD:238113	84/241 (35%)
TMPRSS3	NP_076927.1	LDLa	74..107	CDD:238060
		SRCR_2	112..210	CDD:292133
		Tryp_SPc	216..444	CDD:214473	83/239 (35%)
		Tryp_SPc	217..447	CDD:238113	84/241 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910