DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31269 and TMPRSS4

DIOPT Version :9

Sequence 1:	NP_001097818.1	Gene:	CG31269 / 318653	FlyBaseID:	FBgn0051269	Length:	273	Species:	Drosophila melanogaster
Sequence 2:	XP_005271670.1	Gene:	TMPRSS4 / 56649	HGNCID:	11878	Length:	494	Species:	Homo sapiens

Alignment Length:	287	Identity:	93/287 - (32%)
Similarity:	131/287 - (45%)	Gaps:	43/287 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LSG-LVSITAIRIKGNSTDGRFYKDQRIIGGQAAEDGFAPYQISLQGISGAHSCGGAIINETFVL 75
            ||| |||:..:..      |:..|..|::|.:.|.....|:|:|:| ....|.|||:|::..:||
Human   184 LSGSLVSLHCLAC------GKSLKTPRVVGVEEASVDSWPWQVSIQ-YDKQHVCGGSILDPHWVL 241

  Fly    76 TAAHCV--ENAFIPWLVVVTGTNKYNQPGGRYFLKAIHIHCNYDNPEMHNDIALLELVEPIAWDE 138
            |||||.  ......| .|..|::|..........|.|.|..|...|: .|||||::|..|:.:..
Human   242 TAAHCFRKHTDVFNW-KVRAGSDKLGSFPSLAVAKIIIIEFNPMYPK-DNDIALMKLQFPLTFSG 304

  Fly   139 RTQPIPLPLV--PMQPGDEVILTGWGSTVLWG--TSPIDLQVLYLQYVPHRECKALLSNDEDCDV 199
            ..:||.||..  .:.|...:.:.|||.|...|  .|.|.||. .:|.:....|     |.:|...
Human   305 TVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQA-SVQVIDSTRC-----NADDAYQ 363

  Fly   200 GHI-----CTFSRLGEG---ACHGDSGGPLV---SNGYLVGLVNWGWPC-ATGVPDVHASVYFYR 252
            |.:     |  :.:.||   .|.|||||||:   ...::||:|:||:.| ....|.|:..|..|.
Human   364 GEVTEKMMC--AGIPEGGVDTCQGDSGGPLMYQSDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYL 426

  Fly   253 DWIRNV-------MSGNSKCTGFSSNQ 272
            :||.||       .|.||..||....|
Human   427 NWIYNVWKDRTIQRSCNSPGTGLVIQQ 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31269	NP_001097818.1	Tryp_SPc	37..255	CDD:214473	75/235 (32%)
CG31269	NP_001097818.1	Tryp_SPc	38..258	CDD:238113	76/237 (32%)
TMPRSS4	XP_005271670.1	LDLa	58..92	CDD:238060
		SRCR_2	108..197	CDD:295335	6/18 (33%)
		Tryp_SPc	204..429	CDD:214473	75/235 (32%)
		Tryp_SPc	205..432	CDD:238113	76/237 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147506
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840