DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31269 and PRSS1

DIOPT Version :9

Sequence 1:	NP_001097818.1	Gene:	CG31269 / 318653	FlyBaseID:	FBgn0051269	Length:	273	Species:	Drosophila melanogaster
Sequence 2:	XP_011514713.1	Gene:	PRSS1 / 5644	HGNCID:	9475	Length:	472	Species:	Homo sapiens

Alignment Length:	292	Identity:	94/292 - (32%)
Similarity:	141/292 - (48%)	Gaps:	51/292 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LSGLVSITA--------IRIKGNSTD-----------------------GRFYKDQRIIGGQAAE 45
            |.|:|::|:        :|.|..|:.                       ..|..|.:|:||...|
Human   192 LGGVVTLTSQSPPLWILVRYKDESSTTSQAHSTTMNPLLILTFVAAALAAPFDDDDKIVGGYNCE 256

  Fly    46 DGFAPYQISLQGISGAHSCGGAIINETFVLTAAHCVENAFIPWLVVVTGTNKYN-QPGGRYFLKA 109
            :...|||:||.  ||.|.|||::|||.:|::|.||.::.    :.|..|.:... ..|...|:.|
Human   257 ENSVPYQVSLN--SGYHFCGGSLINEQWVVSAGHCYKSR----IQVRLGEHNIEVLEGNEQFINA 315

  Fly   110 IHI--HCNYDNPEMHNDIALLELVEPIAWDERTQPIPLPLVPMQPGDEVILTGWGSTVLWGTS-P 171
            ..|  |..||...::|||.|::|......:.|...|.||..|...|.:.:::|||:|...|.. |
Human   316 AKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYP 380

  Fly   172 IDLQVLYLQYVPHRECKA----LLSNDEDCDVGHICTFSRLGEGACHGDSGGPLVSNGYLVGLVN 232
            .:||.|....:...:|:|    .::::..| ||    |...|:.:|.||||||:|.||.|.|:|:
Human   381 DELQCLDAPVLSQAKCEASYPGKITSNMFC-VG----FLEGGKDSCQGDSGGPVVCNGQLQGVVS 440

  Fly   233 WGWPCA-TGVPDVHASVYFYRDWIRNVMSGNS 263
            ||..|| ...|.|:..||.|..||:|.::.||
Human   441 WGDGCAQKNKPGVYTKVYNYVKWIKNTIAANS 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31269	NP_001097818.1	Tryp_SPc	37..255	CDD:214473	80/226 (35%)
CG31269	NP_001097818.1	Tryp_SPc	38..258	CDD:238113	82/228 (36%)
PRSS1	XP_011514713.1	Ig	19..119	CDD:299845
		IG_like	29..113	CDD:214653
		Tryp_SPc	248..464	CDD:214473	80/226 (35%)
		Tryp_SPc	249..467	CDD:238113	82/228 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469244at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920