DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31269 and TMPRSS12

DIOPT Version :9

Sequence 1:	NP_001097818.1	Gene:	CG31269 / 318653	FlyBaseID:	FBgn0051269	Length:	273	Species:	Drosophila melanogaster
Sequence 2:	NP_872365.2	Gene:	TMPRSS12 / 283471	HGNCID:	28779	Length:	348	Species:	Homo sapiens

Alignment Length:	255	Identity:	84/255 - (32%)
Similarity:	119/255 - (46%)	Gaps:	54/255 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 RIIGGQAAEDGFAPYQISLQ---GISGAHSCGGAIINETFVLTAAHCVENAFIP--WLVVVTGTN 96
            |||||..|:.|..|:.:|||   |....|.|||.::.|.:|||||||.::|..|  |..|: |||
Human    77 RIIGGTEAQAGAWPWVVSLQIKYGRVLVHVCGGTLVRERWVLTAAHCTKDASDPLMWTAVI-GTN 140

  Fly    97 KYNQPGGRY------FLKAIHIHCNYDNPEMHNDIALLELVEPIAWDERTQPIPLPLVPMQPGD- 154
            ..:   |||      .:|||.||.|:......|||||..|.:.:.:::..|||.||....|..|
Human   141 NIH---GRYPHTKKIKIKAIIIHPNFILESYVNDIALFHLKKAVRYNDYIQPICLPFDVFQILDG 202

  Fly   155 --EVILTGWGSTVLWGTSPIDLQVLYLQYVPHRECK------------ALLSNDEDCDVGHICTF 205
              :..::|||.|...|.:...||...:.|:....|.            :..:.|||
Human   203 NTKCFISGWGRTKEEGNATNILQDAEVHYISREMCNSERSYGGIIPNTSFCAGDED--------- 258

  Fly   206 SRLGEGA---CHGDSGGPLV------SNGYLVGLVNWGWPCA-TGVPDVHASVYFYRDWI 255
                 ||   |.|||||||:      ...:::|:.::|..|. .|.|.|:....||:.|:
Human   259 -----GAFDTCRGDSGGPLMCYLPEYKRFFVMGITSYGHGCGRRGFPGVYIGPSFYQKWL 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31269	NP_001097818.1	Tryp_SPc	37..255	CDD:214473	83/253 (33%)
CG31269	NP_001097818.1	Tryp_SPc	38..258	CDD:238113	83/254 (33%)
TMPRSS12	NP_872365.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..63
TMPRSS12	NP_872365.2	Tryp_SPc	78..316	CDD:238113	83/254 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910