DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31269 and PRSS54

DIOPT Version :9

Sequence 1:	NP_001097818.1	Gene:	CG31269 / 318653	FlyBaseID:	FBgn0051269	Length:	273	Species:	Drosophila melanogaster
Sequence 2:	NP_001073961.1	Gene:	PRSS54 / 221191	HGNCID:	26336	Length:	395	Species:	Homo sapiens

Alignment Length:	285	Identity:	74/285 - (25%)
Similarity:	117/285 - (41%)	Gaps:	70/285 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VLLILLGLSGLVSITAIRIKGNSTDGRFYKDQRIIGGQAAEDGFA-----PYQISLQGISGAHSC 64
            |||:||||  |.|.|:..::..|.   ||       |...::|..     |:.:|||.....|..
Human    16 VLLVLLGL--LYSSTSCGVQKASV---FY-------GPDPKEGLVSSMEFPWVVSLQDSQYTHLA 68

  Fly    65 GGAIINETFVLTAAHCVENAFIPWLVVVTGTNKYNQPG----GRYFLKAIHIHCNYDNPEMHNDI 125
            .|.|::|.:||:.|..::|.  ..:||:.|.:..: |.    ..|.:..|.||.::||..|.|:|
Human    69 FGCILSEFWVLSIASAIQNR--KDIVVIVGISNMD-PSKIAHTEYPVNTIIIHEDFDNNSMSNNI 130

  Fly   126 ALLE---------LVEPIAWDERTQPIPLPLVPMQPGDEVILTGWGSTVLWG---TSPI------ 172
            |||:         ||:.|.:..|....| |::     ....::||..|...|   |..:
Human   131 ALLKTDTAMHFGNLVQSICFLGRMLHTP-PVL-----QNCWVSGWNPTSATGNHMTMSVLRKIFV 189

  Fly   173 -DLQVLYLQYVPHRECKALLSNDEDCDVGHICTFSRLGEGACHGDSGGPLVSN------GYLVGL 230
             ||.:..|..:...||.:....:.              :.||.||.|.|::..      ..|.|:
Human   190 KDLDMCPLYKLQKTECGSHTKEET--------------KTACLGDPGSPMMCQLQQFDLWVLRGV 240

  Fly   231 VNWGWPCATGVPDVHASVYFYRDWI 255
            :|:|.....|: .::..|..|..||
Human   241 LNFGGETCPGL-FLYTKVEDYSKWI 264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31269	NP_001097818.1	Tryp_SPc	37..255	CDD:214473	59/251 (24%)
CG31269	NP_001097818.1	Tryp_SPc	38..258	CDD:238113	61/252 (24%)
PRSS54	NP_001073961.1	Tryp_SPc	52..264	CDD:214473	57/235 (24%)
		Tryp_SPc	52..264	CDD:238113	57/235 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	324..348
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147508
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930