DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31269 and F10

DIOPT Version :9

Sequence 1:	NP_001097818.1	Gene:	CG31269 / 318653	FlyBaseID:	FBgn0051269	Length:	273	Species:	Drosophila melanogaster
Sequence 2:	NP_000495.1	Gene:	F10 / 2159	HGNCID:	3528	Length:	488	Species:	Homo sapiens

Alignment Length:	243	Identity:	79/243 - (32%)
Similarity:	113/243 - (46%)	Gaps:	30/243 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 RIIGGQAAEDGFAPYQISLQGISGAHSCGGAIINETFVLTAAHCVENAFIPWLVVVTGTNKYNQP 101
            ||:|||..:||..|:|..|........|||.|::|.::||||||:..| ..:.|.|...|...:.
Human   234 RIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQA-KRFKVRVGDRNTEQEE 297

  Fly   102 GGRYFLKAIH-----IHCNYDNPEMHN-DIALLELVEPIAWDERTQPIPLP--------LVPMQP 152
            ||    :|:|     |..|....|.:: |||:|.|..||.:.....|..||        |:..:.
Human   298 GG----EAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKT 358

  Fly   153 GDEVILTGWGSTVLWGTSPIDLQVLYLQYVPHRECKALLSNDEDCDVGHICT-FSRLGEGACHGD 216
            |   |::|:|.|...|.....|::|.:.||....||  ||:.........|. :....|.||.||
Human   359 G---IVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCK--LSSSFIITQNMFCAGYDTKQEDACQGD 418

  Fly   217 SGGPLVS----NGYLVGLVNWGWPCA-TGVPDVHASVYFYRDWIRNVM 259
            ||||.|:    ..::.|:|:||..|| .|...::..|..:..||...|
Human   419 SGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSM 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31269	NP_001097818.1	Tryp_SPc	37..255	CDD:214473	76/237 (32%)
CG31269	NP_001097818.1	Tryp_SPc	38..258	CDD:238113	77/239 (32%)
F10	NP_000495.1	GLA	25..85	CDD:214503
		EGF_CA	86..122	CDD:238011
		FXa_inhibition	129..164	CDD:317114
		O-glycosylated at one site	183..203
		Tryp_SPc	235..464	CDD:238113	77/238 (32%)
		O-glycosylated at one site	476..485
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910