DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31269 and F2

DIOPT Version :9

Sequence 1:	NP_001097818.1	Gene:	CG31269 / 318653	FlyBaseID:	FBgn0051269	Length:	273	Species:	Drosophila melanogaster
Sequence 2:	NP_000497.1	Gene:	F2 / 2147	HGNCID:	3535	Length:	622	Species:	Homo sapiens

Alignment Length:	272	Identity:	84/272 - (30%)
Similarity:	127/272 - (46%)	Gaps:	58/272 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 YKDQRIIGGQAAEDGFAPYQISLQGISGAH-SCGGAIINETFVLTAAHCVENAFIPW-------- 88
            |.|.||:.|..||.|.:|:|:.|...|... .||.::|::.:|||||||:  .:.||
Human   359 YIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCL--LYPPWDKNFTEND 421

  Fly    89 LVVVTGTNKYNQPGGRY--------FLKAIHIHCNYD-NPEMHNDIALLELVEPIAWDERTQPIP 144
            |:|..|  |:::.  ||        .|:.|:||..|: ...:..||||::|.:|:|:.:...|:.
Human   422 LLVRIG--KHSRT--RYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVC 482

  Fly   145 LP-----LVPMQPGDEVILTGWGS-TVLWGTS-----PIDLQVLYLQYVPHRECK-----ALLSN 193
            ||     ...:|.|.:..:||||: ...|..:     |..|||:.|..|....||     .:..|
Human   483 LPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDN 547

  Fly   194 DEDCDVGHICTFSRLGEG----ACHGDSGGPLV------SNGYLVGLVNWGWPC-ATGVPDVHAS 247
                   ..|...:..||    ||.||||||.|      :..|.:|:|:||..| ..|....:..
Human   548 -------MFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTH 605

  Fly   248 VYFYRDWIRNVM 259
            |:..:.||:.|:
Human   606 VFRLKKWIQKVI 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31269	NP_001097818.1	Tryp_SPc	37..255	CDD:214473	79/262 (30%)
CG31269	NP_001097818.1	Tryp_SPc	38..258	CDD:238113	80/264 (30%)
F2	NP_000497.1	GLA	25..88	CDD:214503
		KR	105..186	CDD:238056
		KR	211..293	CDD:214527
		Thrombin_light	317..363	CDD:286482	2/3 (67%)
		Tryp_SPc	363..613	CDD:214473	79/262 (30%)
		Tryp_SPc	364..616	CDD:238113	80/264 (30%)
		High affinity receptor-binding region which is also known as the TP508 peptide	551..573		10/21 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910