DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31269 and TMPRSS6

DIOPT Version :9

Sequence 1:	NP_001097818.1	Gene:	CG31269 / 318653	FlyBaseID:	FBgn0051269	Length:	273	Species:	Drosophila melanogaster
Sequence 2:	NP_001275929.1	Gene:	TMPRSS6 / 164656	HGNCID:	16517	Length:	824	Species:	Homo sapiens

Alignment Length:	264	Identity:	80/264 - (30%)
Similarity:	123/264 - (46%)	Gaps:	46/264 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 RIIGGQAAEDGFAPYQISLQGISGAHSCGGAIINETFVLTAAHCVEN----AFIPWLVVVTGTNK 97
            ||:||..:.:|..|:|.||| :.|.|.||||:|.:.:|:|||||.:.    :.:.|.|.: |...
Human   567 RIVGGAVSSEGEWPWQASLQ-VRGRHICGGALIADRWVITAAHCFQEDSMASTVLWTVFL-GKVW 629

  Fly    98 YNQ--PGGRYF-LKAIHIHCNYDNPEMHNDIALLELVEPIAWDERTQPIPLPLVP--MQPGDEVI 157
            .|.  ||...| :..:.:|..::......|:|||:|..|:......:|:.||...  .:||....
Human   630 QNSRWPGEVSFKVSRLLLHPYHEEDSHDYDVALLQLDHPVVRSAAVRPVCLPARSHFFEPGLHCW 694

  Fly   158 LTGWGS-----------TVLWG---------TSPID--LQVLYLQYVPHRECKALLSNDEDCDVG 200
            :||||:           .:.:|         ..||.  ||.:.:|.:|...|..:........:
Human   695 ITGWGALREGALRADAVALFYGWRNQGSETCCCPISNALQKVDVQLIPQDLCSEVYRYQVTPRM- 758

  Fly   201 HICTFSRLG-EGACHGDSGGPLVSNG-----YLVGLVNWGWPCATGVPD---VHASVYFYRDWIR 256
             :|...|.| :.||.||||||||...     :|.|||:||..|  |.|:   |:..:.....||:
Human   759 -LCAGYRKGKKDACQGDSGGPLVCKALSGRWFLAGLVSWGLGC--GRPNYFGVYTRITGVISWIQ 820

  Fly   257 NVMS 260
            .|::
Human   821 QVVT 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31269	NP_001097818.1	Tryp_SPc	37..255	CDD:214473	77/257 (30%)
CG31269	NP_001097818.1	Tryp_SPc	38..258	CDD:238113	78/259 (30%)
TMPRSS6	NP_001275929.1	SEA	77..177	CDD:307516
		CUB	326..440	CDD:238001
		LDLa	450..480	CDD:238060
		LDLa	486..516	CDD:238060
		Ldl_recept_a	520..557	CDD:278486
		Tryp_SPc	568..822	CDD:238113	78/259 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910