DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31267 and KLKB1

DIOPT Version :9

Sequence 1:	NP_732214.1	Gene:	CG31267 / 318651	FlyBaseID:	FBgn0051267	Length:	275	Species:	Drosophila melanogaster
Sequence 2:	XP_011530232.1	Gene:	KLKB1 / 3818	HGNCID:	6371	Length:	649	Species:	Homo sapiens

Alignment Length:	268	Identity:	84/268 - (31%)
Similarity:	126/268 - (47%)	Gaps:	54/268 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 TSEKSETANKFSSRIVGGEESDVLAAPYLVSLQ--NAYGNHFCAGSIIHDQWVITAASCLAGLRK 93
            |.:.|....|.|:|||||..|.....|:.||||  .....|.|.||:|..|||:|||.|..||..
Human   388 TGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCFDGLPL 452

  Fly    94 NNVQVVTTTYNHWGSEGW-IYS----------------VEDIVMHCNFDSPMYHNDIALIKTHAL 141
            .:|              | |||                :::|::|.|:.....::||||||..|.
Human   453 QDV--------------WRIYSGILNLSDITKDTPFSQIKEIIIHQNYKVSEGNHDIALIKLQAP 503

  Fly   142 FDYDDVTQNITIAPLEDLTDGETLTMY------GYGSTEIGGDFSWQLQQLDVTYVAPEKCNATY 200
            .:|.:..:.|.:.     :.|:|.|:|      |:|.::..|:....||::::..|..|:|...|
Human   504 LNYTEFQKPICLP-----SKGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNIPLVTNEECQKRY 563

  Fly   201 GGTPDLDVGH--LCAVGKVGA-GACHGDTGGPIV---DSRGRLVGVGNWGVPCG-YGFPDVFARI 258
               .|..:..  :||..|.|. .||.||:|||:|   :...||||:.:||..|. ...|.|:.::
Human   564 ---QDYKITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGEGCARREQPGVYTKV 625

  Fly   259 SFYYSWII 266
            :.|..||:
Human   626 AEYMDWIL 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31267	NP_732214.1	Tryp_SPc	44..265	CDD:214473	78/252 (31%)
CG31267	NP_732214.1	Tryp_SPc	45..268	CDD:238113	79/254 (31%)
KLKB1	XP_011530232.1	APPLE	21..104	CDD:128519
		APPLE	111..194	CDD:128519
		APPLE	212..295	CDD:128519
		APPLE	303..386	CDD:128519
		Tryp_SPc	401..632	CDD:214473	78/252 (31%)
		Tryp_SPc	402..632	CDD:238113	77/251 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141689
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840