DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31267 and CFI

DIOPT Version :9

Sequence 1:	NP_732214.1	Gene:	CG31267 / 318651	FlyBaseID:	FBgn0051267	Length:	275	Species:	Drosophila melanogaster
Sequence 2:	NP_001362207.1	Gene:	CFI / 3426	HGNCID:	5394	Length:	601	Species:	Homo sapiens

Alignment Length:	193	Identity:	49/193 - (25%)
Similarity:	88/193 - (45%)	Gaps:	29/193 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 RIVGGEESDVLAAPYLVSLQNAYGNHFCAGSIIHDQWVITAASCLAGLRKNNVQVVTTTYNHWGS 108
            |||||:.:.:...|:.|::::|.| ..|.|..|...|::|||.||...:.:..|:.||..:
Human   347 RIVGGKRAQLGDLPWQVAIKDASG-ITCGGIYIGGCWILTAAHCLRASKTHRYQIWTTVVD---- 406

  Fly   109 EGWIYS---------VEDIVMHCNFDSPMYHNDIALIKTHALFDYDD------VTQNITIAPLED 158
              ||:.         |:.|:.|.|:::..|.||||||:.....:..|      :...:..:|..
Human   407 --WIHPDLKRIVIEYVDRIIFHENYNAGTYQNDIALIEMKKDGNKKDCELPRSIPACVPWSPYL- 468

  Fly   159 LTDGETLTMYGYGSTEIGGDFSWQLQQLDVTYVAPEKCNATYGG---TPDLDVGHLCAVGKVG 218
            ....:|..:.|:| .|...:..:.||..:|..::  .|:..||.   ..:::....|:|.:.|
Human   469 FQPNDTCIVSGWG-REKDNERVFSLQWGEVKLIS--NCSKFYGNRFYEKEMECADCCSVAQAG 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31267	NP_732214.1	Tryp_SPc	44..265	CDD:214473	49/193 (25%)
CG31267	NP_732214.1	Tryp_SPc	45..268	CDD:238113	48/192 (25%)
CFI	NP_001362207.1	FIMAC	43..108	CDD:214493
		SR	114..215	CDD:214555
		LDLa	224..256	CDD:238060
		Ldl_recept_a	257..293	CDD:365841
		Tryp_SPc	348..>519	CDD:238113	45/181 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141697
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930