DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31262 and SLC5A6

DIOPT Version :9

Sequence 1:	NP_001138069.2	Gene:	CG31262 / 318649	FlyBaseID:	FBgn0051262	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_066918.2	Gene:	SLC5A6 / 8884	HGNCID:	11041	Length:	635	Species:	Homo sapiens

Alignment Length:	576	Identity:	182/576 - (31%)
Similarity:	294/576 - (51%)	Gaps:	40/576 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FGTVDYLVLVAMTLLSTGTGIYFGALKKKHKNKKSVSEDNRRTNFGSEKIDEYLMGSRNMKVIPV 70
            |..:||:|.|.:.:||...|:|...                 ..:|...:.|.||..|.|..:||
Human    24 FSIMDYVVFVLLLVLSLAIGLYHAC-----------------RGWGRHTVGELLMADRKMGCLPV 71

  Fly    71 SI----TLYRVTSIIGTPSEIYHYGTQYYLIIVAIILQGIAFSYVYLPVYSALQIGSAYEYLGLR 131
            ::    |.....:|:|.|||||.:||||:.:.....|..:..:::::||:..|.:.||||||.||
Human    72 ALSLLATFQSAVAILGVPSEIYRFGTQYWFLGCCYFLGLLIPAHIFIPVFYRLHLTSAYEYLELR 136

  Fly   132 FNSIIRTTASFMYVFGILTYLPFIVYVPALSLSQVSGLNTHLIGLVIILACVTYTFMGGLKAVVH 196
            ||..:|...:..::|.::.|:..::|.|:|:|:.|:|.:..|..|.:.:.|..||.:||||||:.
Human   137 FNKTVRVCGTVTFIFQMVIYMGVVLYAPSLALNAVTGFDLWLSVLALGIVCTVYTALGGLKAVIW 201

  Fly   197 TDVWQVAVMFLSLVAVAFLAIYYSNGLVAVFDDAEQGGRLMLANTNPSPYVRHTVWSVLIGGFSF 261
            |||:|..||||..:||..:......||..|:..|.|.||:.....:|.|:||||.|::..||...
Human   202 TDVFQTLVMFLGQLAVIIVGSAKVGGLGRVWAVASQHGRISGFELDPDPFVRHTFWTLAFGGVFM 266

  Fly   262 WTSVNAGGQHMVQRYMSLPSLKKSRQASFIFTIGVSIF--IALC--CFMGLLLFSKYKDCDPRSA 322
            ..|:....|..||||:|    .::.:|:.:....|..|  ::||  |.:||::|:.|::......
Human   267 MLSLYGVNQAQVQRYLS----SRTEKAAVLSCYAVFPFQQVSLCVGCLIGLVMFAYYQEYPMSIQ 327

  Fly   323 GMILNDDQLLPLFVVQSVGHIYGMPGLFIAGIFGAGLSSLSSCFNTVSMVFLEDIVRGFFKMEPS 387
            ......||.:..||:..:..:.|:||||||.:|...||::||.||:::.|.:||::|.:|. |.|
Human   328 QAQAAPDQFVLYFVMDLLKGLPGLPGLFIACLFSGSLSTISSAFNSLATVTMEDLIRPWFP-EFS 391

  Fly   388 ERQSTILIKTCIIFQGILAFLIVFLLQHLRGILSVCNSISSITAGTSFGVFTLGMLFPWANTIGT 452
            |.::.:|.:......|:|...:.::...:..:|....||..:..|...|:|.|||.||.||..|.
Human   392 EARAIMLSRGLAFGYGLLCLGMAYISSQMGPVLQAAISIFGMVGGPLLGLFCLGMFFPCANPPGA 456

  Fly   453 AVGGLSSVLLAGWISFGSQIAAASGQL-------KSGMLPVSVKECVGNVTLPEDPWVDQDQVFP 510
            .||.|:.:::|.||..||.:.:....:       .|..||.::........:|...:.....:..
Human   457 VVGLLAGLVMAFWIGIGSIVTSMGSSMPPSPSNGSSFSLPTNLTVATVTTLMPLTTFSKPTGLQR 521

  Fly   511 LYRLSYHWVSPIGVVTAVVVGALVSLITKPADIKTLHAELISPVIHR---FLPREC 563
            .|.|||.|.|.....|.:|||.:|||:|.....::|:...|.||:.:   .||..|
Human   522 FYSLSYLWYSAHNSTTVIVVGLIVSLLTGRMRGRSLNPATIYPVLPKLLSLLPLSC 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31262	NP_001138069.2	SLC5sbd_NIS-SMVT	9..522	CDD:271383	166/527 (31%)
SLC5A6	NP_066918.2	SLC5sbd_SMVT	24..550	CDD:271394	174/547 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820