Protein Alignment CG31262 and SLC5A2

DIOPT Version :9

• Sequence 1: NP_001138069.2
• Gene: CG31262 / 318649
• FlyBaseID: FBgn0051262
• Length: 579
• Species: Drosophila melanogaster
• Sequence 2: XP_006721135.2
• Gene: SLC5A2 / 6524
• HGNCID: 11037
• Length: 705
• Species: Homo sapiens
• Alignment Length: 637
• Identity: 147/637 - (23%)
• Similarity: 242/637 - (37%)
• Gaps: 160/637 - (25%)

  Fly     1 MDNYRFGTVDYLVLVAMTLLSTGTGIYFGALKKKHKNKKSVSEDNRRTNFGSEKIDEYLMGSRNM 65
            :||    ..|.||:.|..||..|.|::            |:...||.|      :..|.:..|:|
Human    27 IDN----PADILVIAAYFLLVIGVGLW------------SMCRTNRGT------VGGYFLAGRSM 69

  Fly    66 KVIPVSITLY-------RVTSIIGT--PSEIYHYGTQYYLIIVAIILQGIAFSYVYLPVYSALQI 121
            ...||..:|:       ....:.||  .|.:...|.::..:.|.::|     .:::.|||....:
Human    70 VWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLL-----GWLFAPVYLTAGV 129

  Fly   122 GSAYEYL-----GLRFNSIIRTTASFMYVFGILTYLPFIVYVPALSLSQVSGLNTH-----LIGL 176
            .:..:||     |.|....:...:.|:|:|   |.:...::..|:.:.|..|.|.:     |:|:
Human   130 ITMPQYLRKRFGGRRIRLYLSVLSLFLYIF---TKISVDMFSGAVFIQQALGWNIYASVIALLGI 191

  Fly   177 VIILACVTYTFMGGLKAVVHTDVWQVAVMF---LSLVAVAFLAIYYSNGL----------VAVFD 228
            .:|     ||..|||.|:::||..|..|:.   ..|:..||..:...:||          :.|.:
Human   192 TMI-----YTVTGGLAALMYTDTVQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSLTVSE 251

  Fly   229 DAEQGG-RLMLANTNPSPY--VRHTV-----WSVLIGGFS-----FWTSVNAGGQHMVQRYMSLP 280
            |...|. ........|..|  :||.|     |..|:.|.:     :|.|    .|.:|||.::..
Human   252 DPAVGNISSFCYRPRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCS----DQVIVQRCLAGK 312

  Fly   281 SLKKSRQASFIFTIGVSIFIALCCFMGLL-LFSKYKDCDPRSAGMILNDDQL------------- 331
            ||...:              |.|...|.| |...:....|.....||..|::
Human   313 SLTHIK--------------AGCILCGYLKLTPMFLMVMPGMISRILYPDEVACVVPEVCRRVCG 363

  Fly   332 ---------LPLFVVQSVGHIYGMPGLFIAGIFGAGLSSLSSCFNTVSMVFLEDIVRGFFKMEP- 386
                     .|..||:.:.:  |:.||.:|.:..|.:|||:|.||:.|.:|..||   :.::.|
Human   364 TEVGCSNIAYPRLVVKLMPN--GLRGLMLAVMLAALMSSLASIFNSSSTLFTMDI---YTRLRPR 423

  Fly   387 -SERQSTILIKTCIIFQGILAFLIVFLLQHLRG--ILSVCNSISSITAGTSFGVFTLGMLFPWAN 448
             .:|:..::.:..::|..:::...:.::|..:|  :.....::||..|.....||.|.:..|..|
Human   424 AGDRELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRVN 488

  Fly   449 TIGTAVGGLSSVLLAGWISFGSQIAAASGQLKSGMLPVSVKECVGNVTLPEDPWVDQDQVFPLYR 513
            ..| |..||...||.|......:.:..||            .||            |....|.:.
Human   489 EQG-AFWGLIGGLLMGLARLIPEFSFGSG------------SCV------------QPSACPAFL 528

  Fly   514 LSYHWVSPIGVVTAVVVGAL---VSLITKPADIKTLHAELISPVIHRFLPRE 562
            ...|::. ..:|.....|.|   |||.|.|...|.|| .|:..:.|....||
Human   529 CGVHYLY-FAIVLFFCSGLLTLTVSLCTAPIPRKHLH-RLVFSLRHSKEERE 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31262	NP_001138069.2	SLC5sbd_NIS-SMVT	9..522	CDD:271383	130/584 (22%)
SLC5A2	XP_006721135.2	SLC5sbd_SGLT2	31..705	CDD:212056	145/629 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146441
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750