Protein Alignment CG31262 and SLC5A1

DIOPT Version :10

• Sequence 1: NP_732222.2
• Gene: CG31262 / 318649
• FlyBaseID: FBgn0051262
• Length: 579
• Species: Drosophila melanogaster
• Sequence 2: NP_000334.1
• Gene: SLC5A1 / 6523
• HGNCID: 11036
• Length: 664
• Species: Homo sapiens
• Alignment Length: 643
• Identity: 125/643 - (19%)
• Similarity: 238/643 - (37%)
• Gaps: 162/643 - (25%)

  Fly     9 VDYLVLVAMTLLSTGTGIYFGALKKKHKNKKSVSEDNRRTNFGSEKIDEYLMGSRNMKVIPVSIT 73
            :..:|:..:.:::.|....|.                  ||.|:  :..:.:..|:|...|:..:
Human    29 ISIIVIYFVVVMAVGLWAMFS------------------TNRGT--VGGFFLAGRSMVWWPIGAS 73

  Fly    74 LY-------RVTSIIGT--PSEIYHYGTQYYLIIVAIILQGIAFSYVYLPVYSALQIGSAYEYL- 128
            |:       ....:.||  .|.|...|.::..:::.::|     .::::|:|....:.:..|||
Human    74 LFASNIGSGHFVGLAGTGAASGIAIGGFEWNALVLVVVL-----GWLFVPIYIKAGVVTMPEYLR 133

  Fly   129 ----GLRFNSIIRTTASFMYVFGILTYLPFIVYVPALSLSQVSGLNTHLIGLVIILACVTYTFMG 189
                |.|....:...:..:|:|   |.:...::..|:.::...|||.:|...:::.....||..|
Human   134 KRFGGQRIQVYLSLLSLLLYIF---TKISADIFSGAIFINLALGLNLYLAIFLLLAITALYTITG 195

  Fly   190 GLKAVVHTDVWQVAVMFLSLVAVAFLAIYYSNGLVAVFDDAEQGGRLMLANTNPS---------- 244
            ||.||::||..|..:|.:..:.:...|.:...|..|..:...:....::::.|.:
Human   196 GLAAVIYTDTLQTVIMLVGSLILTGFAFHEVGGYDAFMEKYMKAIPTIVSDGNTTFQEKCYTPRA 260

  Fly   245 --------PYVRHTVWSVLIGGFS-----FWTSVNAGGQHMVQRYMSLPSLKKSRQASFIFTIGV 296
                    |......|...|.|.|     :|.:    .|.:|||.:|..::...:....
Human   261 DSFHIFRDPLTGDLPWPGFIFGMSILTLWYWCT----DQVIVQRCLSAKNMSHVKGGCI------ 315

  Fly   297 SIFIALCCFMGL--------------LLFSKY------KDCDPRSAGMILNDDQLLPLFVVQSVG 341
                 ||.::.|              :|:::.      .:|:......:...:...|..||:.:.
Human   316 -----LCGYLKLMPMFIMVMPGMISRILYTEKIACVVPSECEKYCGTKVGCTNIAYPTLVVELMP 375

  Fly   342 HIYGMPGLFIAGIFGAGLSSLSSCFNTVSMVFLEDIVRGFFKMEPSERQSTILIKTCIIFQGILA 406
            :  |:.||.::.:..:.:|||:|.||:.|.:|..||   :.|:.....:..::|...:....::.
Human   376 N--GLRGLMLSVMLASLMSSLTSIFNSASTLFTMDI---YAKVRKRASEKELMIAGRLFILVLIG 435

  Fly   407 FLIVF--LLQHLRG--ILSVCNSISSITAGTSFGVFTLGMLFPWANTIGTAVGGLSSVLLAGWIS 467
            ..|.:  ::|..:.  :.....||:|........||.|.:.:...|..| |..||...||.|...
Human   436 ISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFWKRVNEPG-AFWGLILGLLIGISR 499

  Fly   468 FGSQIAAASGQLKSGMLPVSVKECVGNVTLPEDPWVDQDQVFPLYRLSYHW------VSPIGVVT 526
            ..::.|..:|   |.|.|   ..|                  |......|:      :..|..:|
Human   500 MITEFAYGTG---SCMEP---SNC------------------PTIICGVHYLYFAIILFAISFIT 540

  Fly   527 AVVVGALVSLITKPADIKTLHAELISPVIHRFLPRECFRGRNLNER-----TEESLIQ 579
            .||    :||:|||.           |.:|  |.|.|:..||..|.     .||..||
Human   541 IVV----ISLLTKPI-----------PDVH--LYRLCWSLRNSKEERIDLDAEEENIQ 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31262	NP_732222.2	SLC5sbd_NIS-SMVT	9..522	CDD:271383	104/579 (18%)
SLC5A1	NP_000334.1	SLC5sbd_SGLT1	27..664	CDD:271379	125/643 (19%)