DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31262 and SLC5A7

DIOPT Version :9

Sequence 1:	NP_001138069.2	Gene:	CG31262 / 318649	FlyBaseID:	FBgn0051262	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_001291934.1	Gene:	SLC5A7 / 60482	HGNCID:	14025	Length:	580	Species:	Homo sapiens

Alignment Length:	480	Identity:	96/480 - (20%)
Similarity:	184/480 - (38%)	Gaps:	125/480 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 RRTNFGS--EKIDEYLMGSRNMKVIPVSITLYRVTSIIGTPSEIYHYGTQYYLIIVAIILQGIAF 108
            |..|.||  |:.:..::|.|::.::....|: ..|.:.|.    |..||     ..|:.:.|...
Human    28 RTKNSGSAEERSEAIIVGGRDIGLLVGGFTM-TATWVGGG----YINGT-----AEAVYVPGYGL 82

  Fly   109 SYVYLPV-YS-ALQIGSAYEYLGLRFNSIIRTTASFMYVFGILTYLPFIVYVPAL---------- 161
            ::...|: || :|.:|..:....:|....:.....|..::|  ..:..::::|||
Human    83 AWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYG--KRMGGLLFIPALMGEMFWAAAI 145

  Fly   162 ------SLSQVSGLNTHLIGLVIILACVTYTFMGGLKAVVHTDVWQVAVMFLSL----------- 209
                  ::|.:..::.|:..::..|....||.:|||.:|.:|||.|:..:|:.|
Human   146 FSALGATISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWISVPFALSHP 210

  Fly   210 -VA-VAFLAIY--YSNGLVAVFDDAEQGGRLMLANTNPSPYVRHTVWS-------VLIGGFSFWT 263
             || :.|.|::  |....:...|.:|                   |:|       :::||.. |
Human   211 AVADIGFTAVHAKYQKPWLGTVDSSE-------------------VYSWLDSFLLLMLGGIP-W- 254

  Fly   264 SVNAGGQHMVQRYMSLPSLKKSRQASFIFTIGVSIFIALCCFMGLLLFS------KYKDCDPRSA 322
                  |...||.:|..|...::..||:...|..:.......:|.:..|      .|...||::.
Human   255 ------QAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDWNQTAYGLPDPKTT 313

  Fly   323 GMILNDDQLLPLFVVQSVGHIYGMPGLFIAGIFGAG------LSSLSSCFNTVSMVFLEDIVRGF 381
            .   ..|.:||: |:|.:..:|       ...||.|      :||..|...:.|.:|..:|.:..
Human   314 E---EADMILPI-VLQYLCPVY-------ISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLS 367

  Fly   382 FKMEPSERQSTILIKTCIIFQGILAFLIVFLLQHLRGILSVCNSISSITAGTSFGVFTLGMLFP- 445
            |:...|:::...:::..:...|..|..:..|.:.:.|:..:.:.:..|            ::||
Human   368 FRQNASDKEIVWVMRITVFVFGASATAMALLTKTVYGLWYLSSDLVYI------------VIFPQ 420

  Fly   446 --------WANTIGTAVGGLSSVLL 462
                    ..||.|...|.:|.:.|
Human   421 LLCVLFVKGTNTYGAVAGYVSGLFL 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31262	NP_001138069.2	SLC5sbd_NIS-SMVT	9..522	CDD:271383	96/480 (20%)
SLC5A7	NP_001291934.1	SLC5sbd_CHT	8..495	CDD:271368	96/480 (20%)
SLC5A7	NP_001291934.1	Mediates interaction with SEC14L1. /evidence=ECO:0000250\|UniProtKB:Q9JMD7	502..580
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146449
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740