DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31262 and slc5a5

DIOPT Version :9

Sequence 1:	NP_001138069.2	Gene:	CG31262 / 318649	FlyBaseID:	FBgn0051262	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_001082860.1	Gene:	slc5a5 / 561445	ZFINID:	ZDB-GENE-060503-585	Length:	601	Species:	Danio rerio

Alignment Length:	574	Identity:	169/574 - (29%)
Similarity:	277/574 - (48%)	Gaps:	40/574 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDNYR---FGTVDYLVLVAMTLLSTGTGIYFGALKKKHKNKKSVSEDNRRTNFGSEKIDEYLMGS 62
            ||:.|   |..|||.|..||..:|.|.|: |.:|:|..               |..|:|.:..|.
Zfish     3 MDSDRPPGFCLVDYAVFAAMLGVSVGIGL-FQSLRKTP---------------GRSKVDSFFTGG 51

  Fly    63 RNMKVIPVSITL----YRVTSIIGTPSEIYHYGTQYYLIIVAIILQGIAFSYVYLPVYSALQIGS 123
            |....:||.::|    .....::|.|||.|.||.::..:.:...|..:..:.:::||:..|:|.|
Zfish    52 RGFSAVPVGLSLCASFMSAVQVLGVPSETYLYGFKFLYMCLGQGLNSLMTAVLFVPVFYRLKITS 116

  Fly   124 AYEYLGLRFNSIIRTTASFMYVFGILTYLPFIVYVPALSLSQVSGLNTHLIGLVIILACVTYTFM 188
            :.:|||:||...::...|..::...|.|...:::.||:.|:|.:|||.........|.|..||.:
Zfish   117 SSQYLGMRFGRGMQLLGSLQFIVATLLYTGIVIFAPAVILNQATGLNMWASLFSTGLICTFYTTV 181

  Fly   189 GGLKAVVHTDVWQVAVMFLSLVAVAFLAIYYSNGLVAVFDDAEQGGRLMLANTNPSPYVRHTVWS 253
            ||:|||:.|||:|:.||....:||.......:.|...|.:.|..|.|:...:....|..|::.||
Zfish   182 GGMKAVIWTDVFQIVVMLSGFIAVFIQGTILAGGPARVLEIANNGSRINFNDFAIDPQRRYSFWS 246

  Fly   254 VLIGGFSFWTSVNAGGQHMVQRYMSLPSLKKSRQASFIFTIGVSIFIALCCFMGLLLFSKYKDCD 318
            ..:||...|.|:....|..||||:|..:.|:::.|..:..:|:.:.::.....|:::|:.|.:||
Zfish   247 FTVGGTMVWLSMYGANQAQVQRYISCRTEKQAQLALLVNQVGLCLIVSSAATCGIVMFALYSNCD 311

  Fly   319 PRSAGMILNDDQLLPLFVVQSVGHIYGMPGLFIAGIFGAGLSSLSSCFNTVSMVFLEDIVRGFFK 383
            |...|.|...||.:|..|:....:..|.||||:|..:...||::|:..|.::.|.:||:::.:.
Zfish   312 PLKIGRISAPDQYMPYLVLDIFRNHPGFPGLFLACAYSGTLSTVSTSINAMAAVTMEDVMKPWL- 375

  Fly   384 MEPSERQSTILIKTCIIFQGILAFLIVFLLQHLR-GILSVCNSISSITAGTSFGVFTLGMLFPWA 447
            :..|:|:..:|.:...:|.|:....:..|...|. |:|....::..:..|...|.|.|||..|..
Zfish   376 ITISQRKQLMLSRALSLFYGLGCITMAALSSLLDWGVLQGSFTVMGVVNGPLLGAFALGMFVPAT 440

  Fly   448 NTIGTAVGGLSSVLLAGWISFGSQIAAASGQLKSGMLPVSVKECV-GNVTLPEDPWVDQDQVFPL 511
            |..|...|......|:.|::.||.|...|.|: .|:||.|..:|: .|.||.....|....| ||
Zfish   441 NKPGVFSGVAVGFCLSLWLAVGSTIYPPSPQI-MGVLPTSAGQCLTTNATLNTTASVLASSV-PL 503

  Fly   512 -------YRLSYHWVSPIGVVTAVVVGALVSLITKPADIKTLHAELISPVIHRF 558
                   |.:||.:...:.....|:||.:||.||.|.     ..:.|||.:.|:
Zfish   504 DYSFQNIYSISYLYFGALSTSAVVLVGVVVSYITGPT-----KKDSISPGLLRW 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31262	NP_001138069.2	SLC5sbd_NIS-SMVT	9..522	CDD:271383	153/525 (29%)
slc5a5	NP_001082860.1	SLC5-6-like_sbd	14..549	CDD:320982	164/558 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580052
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.950