DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31262 and Slc5a8

DIOPT Version :9

Sequence 1:	NP_001138069.2	Gene:	CG31262 / 318649	FlyBaseID:	FBgn0051262	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_001178916.1	Gene:	Slc5a8 / 500820	RGDID:	1564146	Length:	611	Species:	Rattus norvegicus

Alignment Length:	566	Identity:	177/566 - (31%)
Similarity:	290/566 - (51%)	Gaps:	51/566 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDNYR----FGTVDYLVLVAMTLLSTGTGIYFGALKKKHKNKKSVSEDNRRTNFGSEKIDEYLMG 61
            ||..|    |...||:|...|.|:|...|||:..                 ...|.:...::|||
  Rat     1 MDASRDIGSFVVWDYVVFAGMLLISAAIGIYYAF-----------------AGGGQQTSKDFLMG 48

  Fly    62 SRNMKVIPVSITL----YRVTSIIGTPSEIYHYGTQYYLIIVAIILQGIAFSYVYLPVYSALQIG 122
            .|:|..:||:::|    ....:::|||:|:|.:|..:.:..|......:..:.|:|||:..|.|.
  Rat    49 GRSMSAVPVALSLTASFMSAVTVLGTPAEVYRFGAIFSIFGVTYFFVVVISAEVFLPVFYRLGIT 113

  Fly   123 SAYEYLGLRFNSIIRTTASFMYVFGILTYLPFIVYVPALSLSQVSGLNTHLIGLVII--LACVTY 185
            |.||||.||||..||...:.:::...:.|...::|.|||:|:||:|.:  |.|.|:.  :.|..|
  Rat   114 STYEYLELRFNRFIRLCGTVLFIVQTILYTGIVIYAPALALNQVTGFD--LWGAVVATGVVCTFY 176

  Fly   186 TFMGGLKAVVHTDVWQVAVMFLSLVAVAFLAIYYSNGLVAVFDDAEQGGRLMLANTNPSPYVRHT 250
            ..:|||||||.|||:||.:|.....:|...|.....|:..:..||..||||...|.||:|..|||
  Rat   177 CTLGGLKAVVWTDVFQVGIMVAGFASVIIQASITQGGINTILSDASNGGRLNFWNFNPNPLQRHT 241

  Fly   251 VWSVLIGGFSFWTSVNAGGQHMVQRYMSLPSLKKSRQASFIFTIGVSIFIALCCFMGLLLFSKYK 315
            .|::::||...||::....|..||||:|..|...::.:.::..:|:.:.:....|.||.|:|:|.
  Rat   242 FWTIIVGGTFTWTTIYGVNQSQVQRYISCKSRLHAKLSLYVNLVGLWVILICSVFCGLALYSRYH 306

  Fly   316 DCDPRSAGMILNDDQLLPLFVVQSVGHIYGMPGLFIAGIFGAGLSSLSSCFNTVSMVFLEDIVRG 380
            ||||.::..:...|||:|..|:..:.:..|:||||:|..:...||::||..|.::.|.:||:::.
  Rat   307 DCDPWTSKKVSEVDQLMPYLVLDILKNYPGVPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKP 371

  Fly   381 FFKMEPSERQSTILIKTCIIFQGILAFLIVFLLQHLRGILSVCNSISSITAGTSFGVFTLGMLFP 445
            .|| ..||:..:.:.:...:..|.|...:..:...:..:|....||..:..|...|:|:||:|.|
  Rat   372 RFK-SLSEKSLSWISQGMSVLYGALCIGMAAVASLMGALLQAALSIFGMVGGPLLGLFSLGILVP 435

  Fly   446 WANTIGTAVGGLSSVLLAGWISFGSQIAAASGQLKSGMLPVSVKECVGNVTLPEDPWVDQDQV-- 508
            :||::|...|.|:...::.|:..|:|:..   .|....||:|::....|.|.....|:...::
  Rat   436 FANSVGAFAGLLAGFAVSLWVGIGAQLYP---PLPERTLPLSLETHGCNSTHNGTDWMSTTEMPF 497

  Fly   509 ----FPL------------YRLSYHWVSPIGVVTAVVVGALVSLIT 538
                |.:            |.|||.:.|.||.:|.::||.|:||.|
  Rat   498 STSAFQIHDVERSALMDNWYSLSYLYFSTIGTLTTLLVGILISLAT 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31262	NP_001138069.2	SLC5sbd_NIS-SMVT	9..522	CDD:271383	164/536 (31%)
Slc5a8	NP_001178916.1	SLC5sbd_SMCT1	7..549	CDD:271402	174/560 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340214
Domainoid	1	1.000	44	1.000	Domainoid score	I11950
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.850