DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31262 and SLC5A11

DIOPT Version :9

Sequence 1:	NP_001138069.2	Gene:	CG31262 / 318649	FlyBaseID:	FBgn0051262	Length:	579	Species:	Drosophila melanogaster
Sequence 2:	NP_609192.1	Gene:	SLC5A11 / 34117	FlyBaseID:	FBgn0031998	Length:	600	Species:	Drosophila melanogaster

Alignment Length:	590	Identity:	381/590 - (64%)
Similarity:	482/590 - (81%)	Gaps:	13/590 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDNYRFGTVDYLVLVAMTLLSTGTGIYFGALKKKHKNKKSVSE--------DNRRTNFGSEKIDE 57
            |:|||||:|||.|.:.|.:|||.||||||.:||. |.|...:|        ..|:.:|||||:.|
  Fly     9 MENYRFGSVDYAVFLGMIVLSTSTGIYFGCIKKS-KVKLEEAEPTLPTTTPKRRKHDFGSEKMSE 72

  Fly    58 YLMGSRNMKVIPVSITLYRV----TSIIGTPSEIYHYGTQYYLIIVAIILQGIAFSYVYLPVYSA 118
            ||:||||:||.||:::|...    .:|:||.||||:|||||:.|.:||:|||||.||||:||:||
  Fly    73 YLLGSRNLKVFPVAMSLIASYISGVTILGTTSEIYNYGTQYWFIAIAIMLQGIAVSYVYIPVFSA 137

  Fly   119 LQIGSAYEYLGLRFNSIIRTTASFMYVFGILTYLPFIVYVPALSLSQVSGLNTHLIGLVIILACV 183
            ||:||:||||.:||:|::|:.||||::...:.:|||||||||::|:||||:|.|:|.:||::.||
  Fly   138 LQVGSSYEYLEMRFHSVVRSIASFMFILDEILFLPFIVYVPAIALNQVSGINLHVIAVVIVVVCV 202

  Fly   184 TYTFMGGLKAVVHTDVWQVAVMFLSLVAVAFLAIYYSNGLVAVFDDAEQGGRLMLANTNPSPYVR 248
            .|||:||:|||||||.|||.|||||::|||.||..|:|||..:||||.:||||:..|||||||||
  Fly   203 FYTFVGGIKAVVHTDAWQVLVMFLSVLAVAILATVYANGLNVLFDDAAKGGRLIFNNTNPSPYVR 267

  Fly   249 HTVWSVLIGGFSFWTSVNAGGQHMVQRYMSLPSLKKSRQASFIFTIGVSIFIALCCFMGLLLFSK 313
            ||||||||||||:|||.||..|.|||||||||||||:|.:..||||||:.|:::||::|||::..
  Fly   268 HTVWSVLIGGFSYWTSFNAVNQTMVQRYMSLPSLKKARASMAIFTIGVAAFVSVCCYVGLLIYEM 332

  Fly   314 YKDCDPRSAGMILNDDQLLPLFVVQSVGHIYGMPGLFIAGIFGAGLSSLSSCFNTVSMVFLEDIV 378
            ||||||.|||:|.:|||||||||||||||||||.||||||||||.|||||...|:.|:|.|||||
  Fly   333 YKDCDPLSAGLITHDDQLLPLFVVQSVGHIYGMSGLFIAGIFGAALSSLSVVLNSTSLVILEDIV 397

  Fly   379 RGFFKMEPSERQSTILIKTCIIFQGILAFLIVFLLQHLRGILSVCNSISSITAGTSFGVFTLGML 443
            ||.|||:||||.||||:|:.:|..|.:|..:||:|:.|.||||:|.|:::|.|||:||:||||||
  Fly   398 RGCFKMQPSERASTILVKSTVIVLGFVALSLVFVLEQLSGILSICTSMTAIAAGTTFGLFTLGML 462

  Fly   444 FPWANTIGTAVGGLSSVLLAGWISFGSQIAAASGQLKSGMLPVSVKECVGNVTLPEDPWVDQDQV 508
            .|||||:||||||::|.|||||||||:|...|:|:|.|..|||||:.|||||||.|:.|||::||
  Fly   463 VPWANTVGTAVGGIASALLAGWISFGTQFTIAAGELNSQKLPVSVEGCVGNVTLRENIWVDEEQV 527

  Fly   509 FPLYRLSYHWVSPIGVVTAVVVGALVSLITKPADIKTLHAELISPVIHRFLPRECFRGRNLNERT 573
            ||||||||||::||||.|.:||||||||:|||.::|||..:|||||||||||:|||.||||:.:.
  Fly   528 FPLYRLSYHWINPIGVATVIVVGALVSLVTKPTNMKTLDPDLISPVIHRFLPKECFSGRNLHAQA 592

  Fly   574 EESLI 578
            .::|:
  Fly   593 HKNLL 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31262	NP_001138069.2	SLC5sbd_NIS-SMVT	9..522	CDD:271383	337/524 (64%)
SLC5A11	NP_609192.1	SLC5sbd_NIS-SMVT	17..556	CDD:271383	349/539 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45473050
Domainoid	1	1.000	544	1.000	Domainoid score	I933
eggNOG	1	0.900	-	-		E1_COG0591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	716	1.000	Inparanoid score	I1768
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243316at2759
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	1	1.000	-	-		mtm9745
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
	10	9.900