DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31251 and Nudc

DIOPT Version :9

Sequence 1:	NP_732260.2	Gene:	CG31251 / 318645	FlyBaseID:	FBgn0051251	Length:	306	Species:	Drosophila melanogaster
Sequence 2:	NP_035078.1	Gene:	Nudc / 18221	MGIID:	106014	Length:	332	Species:	Mus musculus

Alignment Length:	340	Identity:	81/340 - (23%)
Similarity:	150/340 - (44%)	Gaps:	71/340 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 QRNDAMLMEILQDRK-TITGFLDSIFGFLRRNTDFYHTKRDEADKIGFPKGVRDQILYGAMQRYD 67
            :|.|.||:.:.|..: .:...:::.|.||||.|||:         ||..:|:.::::......::
Mouse     8 ERFDGMLLAMAQQHEGGVQELVNTFFSFLRRKTDFF---------IGGEEGMAEKLITQTFNHHN 63

  Fly    68 PDCLLQSLTAEGGA-------DDGETAPPAVEEVVLESEDGPQ-----DEEMKPIESQPPQK--- 117
            .  |.|....|..|       :..|.|....:|...|: .|||     |||.:.::.:..||
Mouse    64 Q--LAQKARREKRARQETERREKAERAARLAKEAKAET-PGPQIKELTDEEAERLQLEIDQKKDA 125

  Fly   118 ----------------------------GKEQSKFSPSDYKNGDVFETHCWSQTLKDVEVQALLP 154
                                        .|::.|..| :..||.....:.|:|||.::::.....
Mouse   126 EDQEAQLKNGSLDSPGKQDAEDEEDEEDEKDKGKLKP-NLGNGADLPNYRWTQTLAELDLAVPFR 189

  Fly   155 KDHQ-TAKKLHISIQAQHIKVSSKHSPETIILEGNLSQRIKHKEAVWTIDQNRLI-ISYDKAKEL 217
            ...: ..|.:.:.||.:|::|..|..|.  :::|.|...:|.:|:.|.|:..::: :..:|..::
Mouse   190 VSFRLKGKDVVVDIQRRHLRVGLKGQPP--VVDGELYNEVKVEESSWLIEDGKVVTVHLEKINKM 252

  Fly   218 -WWDRLFEGDPEIDSKKIECER-YIDDLPEETQATIEKLRVQQ--------LAADKQQNEIQTSS 272
             ||:||...||||::|||..|. .:.||..||::.:||:...|        .:.::::.||....
Mouse   253 EWWNRLVTSDPEINTKKINPENSKLSDLDSETRSMVEKMMYDQRQKSMGLPTSDEQKKQEILKKF 317

  Fly   273 PDQAINLDRLKAAWD 287
            .||...:|..||.::
Mouse   318 MDQHPEMDFSKAKFN 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31251	NP_732260.2	Nudc_N	5..64	CDD:290757	16/59 (27%)
CG31251	NP_732260.2	p23_NUDC_like	139..223	CDD:107224	21/86 (24%)
Nudc	NP_035078.1	Nudc_N	9..60	CDD:290757	16/59 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..108		11/43 (26%)
		Nuclear localization signal. /evidence=ECO:0000255	68..74		1/5 (20%)
		NuDC	98..>144	CDD:292890	9/46 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	123..171		5/48 (10%)
		p23_mNUDC_like	173..259	CDD:107241	21/87 (24%)
		Interaction with EML4. /evidence=ECO:0000250\|UniProtKB:Q9Y266	174..332		44/159 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2265
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12356
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910