DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31205 and HGF

DIOPT Version :9

Sequence 1:	NP_001287432.1	Gene:	CG31205 / 318626	FlyBaseID:	FBgn0051205	Length:	274	Species:	Drosophila melanogaster
Sequence 2:	NP_000592.3	Gene:	HGF / 3082	HGNCID:	4893	Length:	728	Species:	Homo sapiens

Alignment Length:	277	Identity:	67/277 - (24%)
Similarity:	106/277 - (38%)	Gaps:	54/277 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 TITTL-HPTIQAASVGQECGIFNEKQYNSDNIIAEPTEHPWVVRIVGVTKDGSNTLLCTGILIDS 75
            ||..| ||.|..|..         ||....|.|...|...|:|.:     ...|..:|.|.||..
Human   476 TIVNLDHPVISCAKT---------KQLRVVNGIPTRTNIGWMVSL-----RYRNKHICGGSLIKE 526

  Fly    76 RRVVTAAHCV-SKD--ESESIYGV----VFGDSDSSNINLVSAVTVHPDYSPRKFENDLAIIELT 133
            ..|:||..|. |:|  :.|:..|:    ..||.....:..||.:...|:.|      ||.:::|.
Human   527 SWVLTARQCFPSRDLKDYEAWLGIHDVHGRGDEKCKQVLNVSQLVYGPEGS------DLVLMKLA 585

  Fly   134 KEVVFSDLVQPICLPSVSEMVPGSETSNSKLIVAGLEGPSFDRRHSATQRLDKRIKMTYTKI-DS 197
            :..|..|.|..|.||:....:| .:||.|          .:...::.....|..:::.:..| .:
Human   586 RPAVLDDFVSTIDLPNYGCTIP-EKTSCS----------VYGWGYTGLINYDGLLRVAHLYIMGN 639

  Fly   198 KEC---HEKQARFPEELICGHTERSPLSGSALTEAS-GTP------RQFHLLGIAVAGFFSSDLD 252
            ::|   |..:....|..||...|:   .||...|.. |.|      :...:||:.|.|...:..:
Human   640 EKCSQHHRGKVTLNESEICAGAEK---IGSGPCEGDYGGPLVCEQHKMRMVLGVIVPGRGCAIPN 701

  Fly   253 HQG-YLNIRPHLDWISK 268
            ..| ::.:..:..||.|
Human   702 RPGIFVRVAYYAKWIHK 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31205	NP_001287432.1	Tryp_SPc	44..>168	CDD:304450	35/130 (27%)
HGF	NP_000592.3	PAN_APPLE	39..122	CDD:238074
		KR	126..208	CDD:214527
		KR	210..290	CDD:214527
		KR	304..384	CDD:214527
		KR	388..470	CDD:238056
		Tryp_SPc	494..716	CDD:214473	55/246 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143008
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930