DRSC/TRiP Functional Genomics Resources

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Protein Alignment alpha-Man-Ic and EDEM1

DIOPT Version :10

Sequence 1:NP_733331.1 Gene:alpha-Man-Ic / 318624 FlyBaseID:FBgn0051202 Length:526 Species:Drosophila melanogaster
Sequence 2:NP_055489.1 Gene:EDEM1 / 9695 HGNCID:18967 Length:657 Species:Homo sapiens


Alignment Length:499 Identity:133/499 - (26%)
Similarity:224/499 - (44%) Gaps:89/499 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    68 PDDMRAKIKE----MMMHAWRNYARVVWGTNEFRPISRR-----------VHFGGDFATYKLGAT 117
            |..:||::::    |.:..:.||....:..:|..||..|           ::.......|.|  |
Human   123 PPQLRAQMRDLARGMFVFGYDNYMAHAFPQDELNPIHCRGRGPDRGDPSNLNINDVLGNYSL--T 185

  Fly   118 IIESLDTLHLMGLNKELRRSRDWIEKSFHLDRVDEALSVYELTSRLLCPMLTLYSLTGDS----- 177
            ::::||||.:||.:.|.:::...:..:...|: |..:.|:|.|.|:|..:|:.:.:..||     
Human   186 LVDALDTLAIMGNSSEFQKAVKLVINTVSFDK-DSTVQVFEATIRVLGSLLSAHRIITDSKQPFG 249

  Fly   178 -----------LYMDKAIHIADKILPAFD-TPTGIPRRLVVPKEGSTLTKYLSDISRTSEFGSLH 230
                       |||  |..:|.::||||: |.||||...|..|.|  :....::.:.|:..|||.
Human   250 DMTIKDYDNELLYM--AHDLAVRLLPAFENTKTGIPYPRVNLKTG--VPPDTNNETCTAGAGSLL 310

  Fly   231 LEFYYLSEVSGYPVY----RERVDAIREILAKTTRPNGLYPNAYCTKFGKW----ENYNCSMHRL 287
            :||..||.:.|...:    |..|.|:..:.:..|   ||..|....:.|.|    ......:...
Human   311 VEFGILSRLLGDSTFEWVARRAVKALWNLRSNDT---GLLGNVVNIQTGHWVGKQSGLGAGLDSF 372

  Fly   288 YDTLLKSWIQSGRTDTQNADTFKEAMLAV---------AQNLVVINPEDVTYVSTFRNGTLFHRM 343
            |:.||||:|..|  :.::.:.|..|..::         |.|....:|.....|:.| :|.|.:..
Human   373 YEYLLKSYILFG--EKEDLEMFNAAYQSIQNYLRRGREACNEGEGDPPLYVNVNMF-SGQLMNTW 434

  Fly   344 RHS-DCFAGGLFVL-GAAETQMKHWEKYAHIGIGLTDTC-HDSYWSSPTRLGPDTFAFTEESQQE 405
            ..| ..|..||.|| |..|..:                | |..|::...|.|    |..|....:
Human   435 IDSLQAFFPGLQVLIGDVEDAI----------------CLHAFYYAIWKRYG----ALPERYNWQ 479

  Fly   406 IEPLQRNYYNLRPEVAETYLVLWRITHHPQYRLWGLEMVQAIEKYCRMPYGYTGVMDVNNVTSEP 470
            ::.....:|.||||:.|:..:|::.|.:|.|...|::::|::|||.::..||..:..|  :....
Human   480 LQAPDVLFYPLRPELVESTYLLYQATKNPFYLHVGMDILQSLEKYTKVKCGYATLHHV--IDKST 542

  Fly   471 DDVQGSFFLGSTLKYLYLLFSDDDVV--SLEQWVFNSAGHFLPI 512
            :|...||||..|.|||||||.:|:.|  |..:::|.:.||.:.:
Human   543 EDRMESFFLSETCKYLYLLFDEDNPVHKSGTRYMFTTEGHIVSV 586

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-Man-IcNP_733331.1 Glyco_hydro_47 78..512 CDD:460241 130/483 (27%)
EDEM1NP_055489.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 48..94
Glyco_hydro_47 137..582 CDD:460241 128/479 (27%)
Blue background indicates that the domain is not in the aligned region.

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