DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Man-Ic and MNS3

DIOPT Version :9

Sequence 1:	NP_733331.1	Gene:	alpha-Man-Ic / 318624	FlyBaseID:	FBgn0051202	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001320239.1	Gene:	MNS3 / 839879	AraportID:	AT1G30000	Length:	644	Species:	Arabidopsis thaliana

Alignment Length:	605	Identity:	170/605 - (28%)
Similarity:	266/605 - (43%)	Gaps:	125/605 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 TANTKSRIRIIATGIFTVGVIVITYIQCRAMMRESFQKNIPSNDNSLKD---------------- 65
            |.:||......:||.|.: :|:...:.|..:|.:|      .|::.|.:
plant    54 TLSTKRNYASCSTGKFLI-LILFFGVACLMLMSKS------PNESGLNEKGKVTFVGGLRLGGLL 111

  Fly    66 ---------MNPDD----------------------MRAKIKEMMMHAWRNYARVVWGTNEFRPI 99
                     ::||:                      .:..:||...|||..|.:...|.:|..||
plant   112 RKPPRLPPRLSPDEGQLRGSSTNGSTISNSDPKWAARQQSVKEAFDHAWSGYRKYAMGYDELMPI 176

  Fly   100 SRR--VHFGGDFATYKLGATIIESLDTLHLMGLNKELRRSRDWIEKSFHLDRVDE--ALSVYELT 160
            |::  ...||      ||||::::|||..:|||:..:..:..|:|... |:|:.:  .::::|.|
plant   177 SQKGVDGLGG------LGATVVDALDTAMIMGLDNIVSEAGSWVETHL-LERISQKGQVNLFETT 234

  Fly   161 SRLLCPMLTLYSLTGDS--------------LYMDKAIHIADKILPAF-DTPTGIPRRLVVPKEG 210
            .|:|..:|:.|.|:|..              :|::.|..:||::|.|| .:||.:|...|:..|
plant   235 IRVLGGLLSAYHLSGGEQGTVNMTHVGPKPVIYLNIAKDLADRLLSAFTSSPTPVPFCDVILHE- 298

  Fly   211 STLTKYLSDISRTSEFGSLHLEFYYLSEVSGYPVYRERVDAIREILAKTTRPNGLYPNAYCTKFG 275
            ||........|.|:|..|:.|||.|||.:||.|.|......:...:....:..||.|.....:.|
plant   299 STAHPAPGGASSTAEVASVQLEFNYLSSISGDPKYSTEAMKVLAHIKTLPKTEGLVPIYISPQTG 363

  Fly   276 KWENYNCSM----HRLYDTLLKSWIQSGRTDTQN----ADTFKEAMLAVAQNLVVIN--PEDVTY 330
            .:...|..:    ...|:.|:|.|:|.|.....|    .|.:.|||..| ::|:|.|  |:.:.:
plant   364 DFVGENIRLGSRGDSYYEYLIKVWLQQGAKLNSNFTYLHDMYIEAMKGV-RHLLVQNSIPKGLVF 427

  Fly   331 VSTF---RNGTLFHRMRHSDCFAGGLFVLGAAETQMKH---------WEKYAHIGIG--LTDTCH 381
            |...   ..|....:|.|..||..|...|||.:...|.         :|...::.:.  |..||.
plant   428 VGELPYGSKGEFSPKMDHLVCFLPGTLALGATKGLTKEQALKENLLSFEDLENLKLAEDLAKTCF 492

  Fly   382 DSYWSSPTRLGPDTFAFTEESQQE-----------------IEPLQRNYYNLRPEVAETYLVLWR 429
            :.|..:.|.|.|:...|..:...|                 |:|..|:.. ||||..|:..||:|
plant   493 EMYEVTATGLAPEIAYFHTKDYTEDGLDGGNKSSMYANDIIIKPADRHNL-LRPETVESLFVLYR 556

  Fly   430 ITHHPQYRLWGLEMVQAIEKYCRMPY-GYTGVMDVNNVTSEPDDVQGSFFLGSTLKYLYLLFSDD 493
            ||...:||..|.::.:|.|||.::.. |||.:.||..|.....|...:||||.|||||||||.||
plant   557 ITKDTKYRDQGWQIFEAFEKYTKVKSGGYTSLDDVTEVPPHRRDKMETFFLGETLKYLYLLFGDD 621

  Fly   494 DVVSLEQWVFNSAGHFLPIK 513
            .|:.|:::|||:..|.|||:
plant   622 SVIPLDKFVFNTEAHPLPIR 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-Ic	NP_733331.1	Glyco_hydro_47	78..512	CDD:279825	152/494 (31%)
MNS3	NP_001320239.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54359
OrthoDB	1	1.010	-	-		D693882at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100239
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.830