Protein Alignment alpha-Man-Ic and EDEM3

DIOPT Version :9

• Sequence 1: NP_733331.1
• Gene: alpha-Man-Ic / 318624
• FlyBaseID: FBgn0051202
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_001306889.1
• Gene: EDEM3 / 80267
• HGNCID: 16787
• Length: 948
• Species: Homo sapiens
• Alignment Length: 604
• Identity: 146/604 - (24%)
• Similarity: 238/604 - (39%)
• Gaps: 177/604 - (29%)

  Fly     7 VIRRAQYNWYTANTKSRIRIIATGIFTVGVIVITYIQCRAMMRESFQKNIPSNDNSLKDMNPDDM 71
            |.:||::. ..|.|.:...:.||.::|.|        ...|.||..||                :
Human    13 VPQRARWR-LVAATAAFCLVSATSVWTAG--------AEPMSREEKQK----------------L 52

  Fly    72 RAKIKEMMMHAWRNYARVVWGTNEFRPISRRVHFGG--------DFATYKLGATIIESLDTLHLM 128
            ..::.||..||:.||....:..:|..|::.|....|        |.|..|...|:|:|||||.::
Human    53 GNQVLEMFDHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFSLTLIDSLDTLVVL 117

  Fly   129 GLNKELRRSRDWIEKSFHLDRVDEALSVYELTSRLLCPMLTLYSLT------GDSL--YMDKAIH 185
            ...||...:...:.:..:||. |..:||:|...|:|..:|..:||.      |:.:  |.|:.:.
Human   118 NKTKEFEDAVRKVLRDVNLDN-DVVVSVFETNIRVLGGLLGGHSLAIMLKEKGEYMQWYNDELLQ 181

  Fly   186 IAD----KILPAFDTPTGIPRRLVVPK------EGSTLTKYLSDISRTSEFGSLHLEFYYLSEVS 240
            :|.    |:||||:|.:|:|...:..|      |..|.|:  :| :.|:..|:|.|||..||..:
Human   182 MAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTE--TD-TCTACAGTLILEFAALSRFT 243

  Fly   241 GYPVY----RERVDAIREILAKTTRPNGLYPNAYCTKFGKW----ENYNCSMHRLYDTLLKSWIQ 297
            |..::    |:.:|.:.|...:::...|:..|.:.   |.|    ......:...|:.|||:::.
Human   244 GATIFEEYARKALDFLWEKRQRSSNLVGVTINIHT---GDWVRKDSGVGAGIDSYYEYLLKAYVL 305

  Fly   298 SG------RTDTQ------------------------NADTFKEAMLAVAQNLVVINPEDVTYVS 332
            .|      |.:|.                        ||.|:.:|:||....|.|:..:....:.
Human   306 LGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTWMDALLAFFPGLQVLKGDIRPAIE 370

  Fly   333 TFRNGTLFHRM------RHSDCFAGGLFVLGAAETQMK-HWEKYAHIGIGLTDTCHDSYWSSPTR 390
            |       |.|      :|:       |:..|..|..: ||.::.
Human   371 T-------HEMLYQVIKKHN-------FLPEAFTTDFRVHWAQHP-------------------- 401

  Fly   391 LGPDTFAFTEESQQEIEPLQRNYYNLRPEVAETYLVLWRITHHPQYRLWGLEMVQAIEKYCRMPY 455
                                     ||||.||:...|::.|..|.|...|..:::.:.||.|:|.
Human   402 -------------------------LRPEFAESTYFLYKATGDPYYLEVGKTLIENLNKYARVPC 441

  Fly   456 GYTGVMDVNNVTSEPDDVQGSFFLGSTLKYLYLLFSD--DDVVSLEQWVFNSAGHFLPI------ 512
            |:..:.||.  |...:|...||||....|||||||:|  |.:..:|.::|.:..|.||:
Human   442 GFAAMKDVR--TGSHEDRMDSFFLAEMFKYLYLLFADKEDIIFDIEDYIFTTEAHLLPLWLSTTN 504

  Fly   513 -----KGVNPMYRQHNSSN 526
                 |.....|.:.:.||
Human   505 QSISKKNTTSEYTELDDSN 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-Ic	NP_733331.1	Glyco_hydro_47	78..512	CDD:279825	126/506 (25%)
EDEM3	NP_001306889.1	Glyco_hydro_47	59..498	CDD:279825	126/506 (25%)
		PA_EDEM3_like	664..789	CDD:239041
		Prevents secretion from ER. /evidence=ECO:0000255|PROSITE-ProRule:PRU10138	945..948

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149708
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840