Protein Alignment alpha-Man-Ic and Edem3

DIOPT Version :10

• Sequence 1: NP_733331.1
• Gene: alpha-Man-Ic / 318624
• FlyBaseID: FBgn0051202
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: XP_006529858.1
• Gene: Edem3 / 66967
• MGIID: 1914217
• Length: 948
• Species: Mus musculus
• Alignment Length: 604
• Identity: 147/604 - (24%)
• Similarity: 239/604 - (39%)
• Gaps: 177/604 - (29%)

  Fly     7 VIRRAQYNWYTANTKSRIRIIATGIFTVGVIVITYIQCRAMMRESFQKNIPSNDNSLKDMNPDDM 71
            |.:||.:: ..|.|.:...::||.:.|.|        ...|.||..||                :
Mouse    14 VPQRASWS-LVAATAALCLVLATSVCTAG--------AAPMSREEKQK----------------L 53

  Fly    72 RAKIKEMMMHAWRNYARVVWGTNEFRPISRRVHFGG--------DFATYKLGATIIESLDTLHLM 128
            ..::.||..||:.||....:..:|..|::.|....|        |.|..|...|:|:|||||.::
Mouse    54 GNQVLEMFDHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFSLTLIDSLDTLVVL 118

  Fly   129 GLNKELRRSRDWIEKSFHLDRVDEALSVYELTSRLLCPMLTLYSLT------GDSL--YMDKAIH 185
            ...||...:...:.:..:||. |..:||:|...|:|..:|..:||.      |:.:  |.|:.:|
Mouse   119 NKTKEFEDAVRKVLRDVNLDN-DVVVSVFETNIRVLGGLLGGHSLAIMLKEKGEHMQWYNDELLH 182

  Fly   186 IAD----KILPAFDTPTGIPRRLVVPK------EGSTLTKYLSDISRTSEFGSLHLEFYYLSEVS 240
            :|.    |:||||:|.:|:|...:..|      |..|.|:  :| :.|:..|:|.|||..||..:
Mouse   183 MAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTE--TD-TCTACAGTLILEFAALSRFT 244

  Fly   241 GYPVY----RERVDAIREILAKTTRPNGLYPNAYCTKFGKW----ENYNCSMHRLYDTLLKSWIQ 297
            |..::    |:.:|.:.|...:::...|:..|.:.   |.|    ......:...|:.|||:::.
Mouse   245 GATIFEEYARKALDFLWEKRQRSSNLVGVTINIHT---GDWVRKDSGVGAGIDSYYEYLLKAYVL 306

  Fly   298 SG------RTDTQ------------------------NADTFKEAMLAVAQNLVVINPEDVTYVS 332
            .|      |.:|.                        ||.|:.:|:||....|.|:..:....:.
Mouse   307 LGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTWMDALLAFFPGLQVLKGDIRPAIE 371

  Fly   333 TFRNGTLFHRM------RHSDCFAGGLFVLGAAETQMK-HWEKYAHIGIGLTDTCHDSYWSSPTR 390
            |       |.|      :|:       |:..|..|..: ||.::.
Mouse   372 T-------HEMLYQVIKKHN-------FLPEAFTTDFRVHWAQHP-------------------- 402

  Fly   391 LGPDTFAFTEESQQEIEPLQRNYYNLRPEVAETYLVLWRITHHPQYRLWGLEMVQAIEKYCRMPY 455
                                     ||||.||:...|::.|..|.|...|..:::.:.||.|:|.
Mouse   403 -------------------------LRPEFAESTYFLYKATGDPYYLEVGKTLIENLNKYARVPC 442

  Fly   456 GYTGVMDVNNVTSEPDDVQGSFFLGSTLKYLYLLFSD--DDVVSLEQWVFNSAGHFLPI------ 512
            |:..:.||.  |...:|...||||....|||||||:|  |.:..:|.::|.:..|.||:
Mouse   443 GFAAMKDVR--TGSHEDRMDSFFLAEMFKYLYLLFADKEDIIFDIEDYIFTTEAHLLPLWLSTTN 505

  Fly   513 -----KGVNPMYRQHNSSN 526
                 |.....|.:.:.||
Mouse   506 RSISKKNTTSEYTELDDSN 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-Ic	NP_733331.1	Glyco_hydro_47	78..512	CDD:460241	127/506 (25%)
Edem3	XP_006529858.1	Glyco_hydro_47	60..499	CDD:460241	127/506 (25%)
		PA_EDEM3_like	666..791	CDD:239041
		DMP1	<814..915	CDD:462128