Protein Alignment alpha-Man-Ic and MAN1C1

DIOPT Version :9

• Sequence 1: NP_733331.1
• Gene: alpha-Man-Ic / 318624
• FlyBaseID: FBgn0051202
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_001372111.1
• Gene: MAN1C1 / 57134
• HGNCID: 19080
• Length: 664
• Species: Homo sapiens
• Alignment Length: 492
• Identity: 199/492 - (40%)
• Similarity: 290/492 - (58%)
• Gaps: 46/492 - (9%)

  Fly    72 RAKIKEMMMHAWRNYARVVWGTNEFRPISRRVHFGGDFATYK----------------------- 113
            |.||||||..||::|.|...|.||.||:::..:.|..|....
Human   175 REKIKEMMQFAWQSYKRYAMGKNELRPLTKDGYEGNMFGANPSGEDRVAGKADPCVMPLVMKAGE 239

  Fly   114 ----------LGATIIESLDTLHLMGLNKELRRSRDWIEKSFHLDRVDEALSVYELTSRLLCPML 168
                      .|||:|:|||||:||.|.:|.:.::.|:.:||||:...|| |::|:..|.:..:|
Human   240 NQRRQGDRGLSGATVIDSLDTLYLMELKEEFQEAKAWVGESFHLNVSGEA-SLFEVNIRYIGGLL 303

  Fly   169 TLYSLTGDSLYMDKAIHIADKILPAFDTPTGIPRRLVVPKEGSTLTKYLSDISRTSEFGSLHLEF 233
            :.:.|||:.::..|||.:.:|:||||:||||||:.:|..|.|:.........|..:|||||||||
Human   304 SAFYLTGEEVFRIKAIRLGEKLLPAFNTPTGIPKGVVSFKSGNWGWATAGSSSILAEFGSLHLEF 368

  Fly   234 YYLSEVSGYPVYRERVDAIREILAKTTRPNGLYPNAYCTKFGKWENYNCSMHRL----YDTLLKS 294
            .:|:|:||..|:.|:|..||::|.|..:|.|||||......|.|..::.|:..|    |:.|:||
Human   369 LHLTELSGNQVFAEKVRNIRKVLRKIEKPFGLYPNFLSPVSGNWVQHHVSVGGLGDSFYEYLIKS 433

  Fly   295 WIQSGRTDTQNADTFKEAMLAVAQNLVVINPEDVTYVSTFRNGTLFHRMRHSDCFAGGLFVLGAA 359
            |:.||:||.:..:.:.||:.|:...|:.::|..:||::.:|.|.|.|:|.|..||:||:..|||.
Human   434 WLMSGKTDMEAKNMYYEALEAIETYLLNVSPGGLTYIAEWRGGILDHKMGHLACFSGGMIALGAE 498

  Fly   360 ETQMKHWEKYAHIGIGLTDTCHDSYWSSPTRLGPDTFAFTEESQQEIEPLQRNYYNLRPEVAETY 424
            :.:.:....|..:...:|.|||:||..|.|:|||:.|.|....:.....|..:||.|||||.|:|
Human   499 DAKEEKRAHYRELAAQITKTCHESYARSDTKLGPEAFWFNSGREAVATQLSESYYILRPEVVESY 563

  Fly   425 LVLWRITHHPQYRLWGLEMVQAIEKYCRMPYGYTGVMDVNNVTSEPDDVQGSFFLGSTLKYLYLL 489
            :.|||.||:|.||.||.|:|.|:|||||...|::|:.||.:.|...|:.|.||||..||||||||
Human   564 MYLWRQTHNPIYREWGWEVVLALEKYCRTEAGFSGIQDVYSSTPNHDNKQQSFFLAETLKYLYLL 628

  Fly   490 FSDDDVVSLEQWVFNSAGHFLPIKGVNPMYRQHNSSN 526
            ||:||::|||.||||:..|.||:        .|:.|:
Human   629 FSEDDLLSLEDWVFNTEAHPLPV--------NHSDSS 657

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-Ic	NP_733331.1	Glyco_hydro_47	78..512	CDD:279825	191/470 (41%)
MAN1C1	NP_001372111.1	Glyco_hydro_47	181..651	CDD:396217	191/470 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149706
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2204
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54359
OrthoDB	1	1.010	-	-		D263455at33208
OrthoFinder	1	1.000	-	-		FOG0001280
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100239
Panther	1	1.100	-	-	O	PTHR11742
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X635
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.720