DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Man-Ic and man1b1b

DIOPT Version :9

Sequence 1:	NP_733331.1	Gene:	alpha-Man-Ic / 318624	FlyBaseID:	FBgn0051202	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001093449.1	Gene:	man1b1b / 556237	ZFINID:	ZDB-GENE-070705-482	Length:	632	Species:	Danio rerio

Alignment Length:	464	Identity:	155/464 - (33%)
Similarity:	248/464 - (53%)	Gaps:	48/464 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 IKEMMMHAWRNYARVVWGTNEFRPISRRVHFGGDFATYKLGATIIESLDTLHLMGLNKELRRSRD 139
            ::|...|||:.|....||.:|.:|||:..   |::  :.||.|:|::|||:.::||.:|...:|:
Zfish   186 VREAFRHAWKGYKDFAWGHDELKPISKSY---GEW--FGLGLTLIDALDTMWILGLQEEFAEARE 245

  Fly   140 WIEKSFHLDR-VDEALSVYELTSRLLCPMLTLYSLTGDSLYMDKAIHIADKILPAFDTPTGIPRR 203
            |:.|....|: ||  ::::|.|.|:|..:|:.|.||||:|::|||..|..:::|||.||:.||..
Zfish   246 WVAKELSFDKNVD--VNLFESTIRILGGLLSTYHLTGDNLFLDKAKEIGFRLMPAFSTPSKIPYS 308

  Fly   204 LV-VPKEGSTLTKYLSDISRTSEFGSLHLEFYYLSEVSGYPVYRERV-DAIREILAKTTRPNGLY 266
            .| :.|..:...::.|| |..:|..|:.|||..||.::|.|.|:..| :.::::.....:.:||.
Zfish   309 DVNIGKGTAHPPRWTSD-STVAEVTSIQLEFRELSRLTGDPKYKLAVMEVMKQVHKLDGKQDGLV 372

  Fly   267 PNAYCTKFGKWEN-----YNCSMHRLYDTLLKSWIQSGRTDTQNADTFKEAMLAVAQNLV-VINP 325
            |....|..|.:.:     ........|:.|||.|||.||.:.:..:.:.:|:..|.:||: ...|
Zfish   373 PMFINTNNGLFTHQGIYTLGARADSYYEYLLKQWIQGGRIEQELLEDYLQAVEGVKKNLLKKSTP 437

  Fly   326 EDVTYVSTFRNGTLFHRMRHSDCFAGGLFVLGAAETQMKHWEKYAHIGI---------GLTDTCH 381
            ..:|:|....:|....:|.|..||..|...||            .|.|:         .|.:||:
Zfish   438 LGLTFVGELSHGHFSPKMDHLVCFLPGTLALG------------VHYGLPADHMELAKQLIETCY 490

  Fly   382 DSYWSSPTRLGPDT--FAFTEESQQEIEPLQRNYYN-LRPEVAETYLVLWRITHHPQYRLWGLEM 443
            ..|....|.|.|:.  |...:.|.|:::....:.:| ||||..|:...|:|:|...:|:.||.|:
Zfish   491 QMYAQMETGLSPEIAHFNMHDGSTQDVDVKIADRHNLLRPETVESLFYLYRLTRDKKYQQWGWEI 555

  Fly   444 VQAIEKYCRMPYGYTGVMDVNNVT----SEPDDVQGSFFLGSTLKYLYLLFSDD-DVVSLEQWVF 503
            :|...||.|:|.|  |...:|||.    :.|.|...|||||.||||.|||||:| .::||:::||
Zfish   556 LQNFNKYTRVPTG--GYTSINNVRDPSYTSPRDKMESFFLGETLKYFYLLFSEDPTLISLDKYVF 618

  Fly   504 NSAGHFLPI 512
            |:..|.||:
Zfish   619 NTEAHPLPV 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-Ic	NP_733331.1	Glyco_hydro_47	78..512	CDD:279825	153/459 (33%)
man1b1b	NP_001093449.1	Glyco_hydro_47	189..627	CDD:279825	153/459 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54359
OrthoDB	1	1.010	-	-		D263455at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100239
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.830