DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Man-Ic and Man1b1

DIOPT Version :9

Sequence 1:	NP_733331.1	Gene:	alpha-Man-Ic / 318624	FlyBaseID:	FBgn0051202	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001102666.1	Gene:	Man1b1 / 499751	RGDID:	1563595	Length:	657	Species:	Rattus norvegicus

Alignment Length:	509	Identity:	158/509 - (31%)
Similarity:	259/509 - (50%)	Gaps:	53/509 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 TYIQCRAMMRESFQKNIPSN---DNSLKDM-----------NPDDMRAKIKEMMMHAWRNYARVV 90
            |.|..|..:.|..|...|.:   :.|:|.:           .|::.:..:.|..:|||:.|.:..
  Rat   162 TVISWRGAVIEPEQATEPPSKRAEASIKPLFLASRIWKEPAPPNERQKGVIEAFLHAWKGYQKFA 226

  Fly    91 WGTNEFRPISRRVH--FGGDFATYKLGATIIESLDTLHLMGLNKELRRSRDWIEKSFHLDR-VDE 152
            ||.:|.:|:|:...  ||       ||.|:|::|||:.::||.:|.:.:|.|:.::....: ||
  Rat   227 WGHDELKPVSKTFSEWFG-------LGLTLIDALDTMWILGLKQEFKEARKWVSENLDFQKNVD- 283

  Fly   153 ALSVYELTSRLLCPMLTLYSLTGDSLYMDKAIHIADKILPAFDTPTGIPRRLVVPKEGSTLTKYL 217
             ::::|.|.|:|..:|:.|.|:||||::.||....::::|||.||:.||...|....|...:...
  Rat   284 -VNLFESTIRILGGLLSAYHLSGDSLFLSKAEDFGNRLMPAFTTPSKIPYSDVNIGTGFAHSPQW 347

  Fly   218 SDISRTSEFGSLHLEFYYLSEVSGYPVYRERVDAI-REILAKTTRPNGLYPNAYCTKFGKWEN-- 279
            :..|..:|..|:.|||..||.::|...::|.|:.: :.|.:.:.:.:||.|....|..|.:.:
  Rat   348 TSDSTVAEVTSIQLEFRELSRLTGIKKFQEAVEEVTKHIHSLSGKKDGLVPMFINTNSGLFTHPG 412

  Fly   280 ---YNCSMHRLYDTLLKSWIQSGRTDTQNADTFKEAMLAVAQNLV-VINPEDVTYVSTFRNGTLF 340
               ........|:.|||.|||.|:.:||..:.:..|:..:..:|: ...|..:|:|....:|...
  Rat   413 VFTLGARADSYYEYLLKQWIQGGKKETQLLEDYVRAIEGIKAHLLRQSQPRKLTFVGELAHGRFS 477

  Fly   341 HRMRHSDCFAGGLFVLGAAETQMKHWEKYAHIGI--GLTDTCHDSYWSSPTRLGPDTFAF----- 398
            .:|.|..||..|...||     :.|.....|:.:  .|.:||:.......|.|.|:...|
  Rat   478 AKMDHLVCFLPGTLALG-----VHHGLPADHMDLARALMETCYQMNQQMETGLSPEIAHFNMYPR 537

  Fly   399 TEESQQEIEPLQRNYYNLRPEVAETYLVLWRITHHPQYRLWGLEMVQAIEKYCRMPYGYTGVMDV 463
            .:....|::|..|:.. ||||..|:...|:|:|...:|:.||.|::|:..||.|:|.|  |...:
  Rat   538 ADHKDVEVKPADRHNL-LRPETVESLFYLYRVTKDRKYQDWGWEILQSFNKYTRVPSG--GYSSI 599

  Fly   464 NNVTS----EPDDVQGSFFLGSTLKYLYLLFSDD-DVVSLEQWVFNSAGHFLPI 512
            |||.:    ||.|...|||:|.|||||||||||| :::.|:..|||:..|.|||
  Rat   600 NNVQNSHKPEPRDKMESFFVGETLKYLYLLFSDDLELLGLDTCVFNTEAHPLPI 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-Ic	NP_733331.1	Glyco_hydro_47	78..512	CDD:279825	146/455 (32%)
Man1b1	NP_001102666.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	118..157
Man1b1	NP_001102666.1	Glyco_hydro_47	214..653	CDD:279825	146/455 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54359
OrthoDB	1	1.010	-	-		D263455at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100239
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.830