DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Man-Ic and Edem2

DIOPT Version :9

Sequence 1:	NP_733331.1	Gene:	alpha-Man-Ic / 318624	FlyBaseID:	FBgn0051202	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_609611.1	Gene:	Edem2 / 34714	FlyBaseID:	FBgn0032480	Length:	801	Species:	Drosophila melanogaster

Alignment Length:	533	Identity:	135/533 - (25%)
Similarity:	225/533 - (42%)	Gaps:	107/533 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 IFTVGVIVITYIQCRAMMRESFQKNIPSNDNSLKDMNPDDMRAKIKEMMMHAWRNYARVVWGTNE 95
            ||.|.:.::  :.|..    |.:..:|:.:.|.|:.  .::|.:.::|..||:..|.:..:..:|
  Fly    18 IFLVAMCIV--VACVL----STETTMPTQNMSNKER--AELREEARDMFYHAYNAYMQNAYPADE 74

  Fly    96 FRPISRRVHFGG--------DFATYKLGATIIESLDTLHLMGLNKELRRSRDWIEKSFHLDRVDE 152
            ..|:|.:..:.|        |........|::::||||.|:|...|...:...:.:....|. |.
  Fly    75 LMPLSCKGRYRGVTPSRGDMDDILGNFSMTLVDTLDTLVLLGDFTEFDHAVKLVIRDVQFDS-DI 138

  Fly   153 ALSVYELTSRLLCPML--------------TLYSLTGDSLYMDKAIHIADKILPAFDTPTGIPRR 203
            .:||:|...|::..:|              |::...|:.|.|.:  .:..::||||:|.||||..
  Fly   139 IVSVFETNIRMVGGLLSAHILAEYLQKHADTMHWYKGELLEMSR--ELGYRLLPAFNTSTGIPHA 201

  Fly   204 LVVPKEG---STLTKYLSDISRTSEFGSLHLEFYYLSEVSGYPVYRERVDAIREILAKTT-RPNG 264
            .|..:.|   ..|.|  |..:.|:..|::.|||..||.::|.|::..|..|..:.|.|.. |.:.
  Fly   202 RVNLRLGMKDPMLKK--SRETCTACAGTILLEFAALSRLTGDPIFEVRAHAAMDALWKLRHRGSD 264

  Fly   265 LYPNAYCTKFGKW----ENYNCSMHRLYDTLLKSWIQSGRTDTQNADTFKEAMLAVAQNLVVINP 325
            |.........|.|    ......:...|:.|.||::..|  |.:....|.....||
  Fly   265 LMGTVLNVHSGDWVRRDSGVGAGIDSYYEYLFKSYVLLG--DDKYLARFNRHYNAV--------- 318

  Fly   326 EDVTYVSTFRNG-----TLFHR--------MRHSDCFAGGLFVLG-----AAET-QMKHWEKYAH 371
              :.|||   .|     .|.||        |.....|..||.||.     |.:| :|.:.....|
  Fly   319 --MKYVS---EGPMLLDVLMHRPHAKSKNFMDSLLAFWPGLQVLSGDLKPAVQTHEMLYQVMQMH 378

  Fly   372 IGIGLTDTCHDSYWSSPTRLGPDTFAFTEESQQEIEPLQRNYYNLRPEVAETYLVLWRITHHPQY 436
            ..|                  |:  |||.:.|     :....:.||||..|:...|:|.|....|
  Fly   379 TFI------------------PE--AFTVDFQ-----IHWGQHPLRPEFIESTYFLYRATGDHHY 418

  Fly   437 RLWGLEMVQAIEKYCRMPYGYTGVMDVNNVTSEPDDVQGSFFLGSTLKYLYLLFSD--DDVVSLE 499
            ...|.:.::.::::.::..||..|.||.  |.:.:|...||.|..|:|||:|||||  |.:::::
  Fly   419 LQVGKKALKTLQQHAKVSCGYAAVNDVR--TGKHEDRMDSFVLSETIKYLFLLFSDPQDLIINVD 481

  Fly   500 QWVFNSAGHFLPI 512
            ::||.:..|.||:
  Fly   482 EFVFTTEAHLLPL 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-Ic	NP_733331.1	Glyco_hydro_47	78..512	CDD:279825	125/484 (26%)
Edem2	NP_609611.1	Glyco_hydro_47	57..494	CDD:279825	125/484 (26%)
Edem2	NP_609611.1	PA_EDEM3_like	645..770	CDD:239041
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453088
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840