DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Man-Ic and Edem2

DIOPT Version :9

Sequence 1:	NP_733331.1	Gene:	alpha-Man-Ic / 318624	FlyBaseID:	FBgn0051202	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001004230.1	Gene:	Edem2 / 296304	RGDID:	1303074	Length:	576	Species:	Rattus norvegicus

Alignment Length:	513	Identity:	126/513 - (24%)
Similarity:	216/513 - (42%)	Gaps:	112/513 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 PSNDNSLKDMNPDDMRAKIKEMMMHAWRNYARVVWGTNEFRPISRRVH-FGGDFATYKLGATIIE 120
            |..:.:..|  |...|.::|.|..||:.:|....:..:|.||::...| ..|.|:     .|:|:
  Rat    23 PGPEGTAPD--PAHYRERVKAMFYHAYDSYLENAFPYDELRPLTCDGHDTWGSFS-----LTLID 80

  Fly   121 SLDTLHLMGLNKELRRSRDWIEKSFHLDRVDEALSVYELTSRLLCPMLTLYSL------------ 173
            :||||.::|...|.:|..:.::.:...| :|...||:|...|::..:|:.:.|
  Rat    81 ALDTLLILGNTSEFQRVVEVLQDNVDFD-IDVNASVFETNIRVVGGLLSAHLLSKKAGVEVEAGW 144

  Fly   174 --TGDSLYMDKAIHIADKILPAFDTPTGIPRRLVVPKEGSTLTKYLSDISRTSEFGSLHLEFYYL 236
              :|..|.|  |...|.|:||||.||||:|...|....|  :....:.::.|:..|:..:||..|
  Rat   145 PCSGPLLRM--AEEAARKLLPAFQTPTGMPYGTVNLLHG--VNPGETPVTCTAGIGTFIVEFATL 205

  Fly   237 SEVSGYPVYRE--RVDAIREILAKTTRPNGLYPNAYCTKFGKWENYNCSMHRLYDTLLKSWIQSG 299
            |.::|.||:.:  ||..:|  |.::....||..|......|||...:..:....|:..:..:
  Rat   206 SSLTGDPVFEDVARVALMR--LWESRSDIGLVGNHIDVLTGKWVAQDAGIGAGVDSYFEYLV--- 265

  Fly   300 RTDTQNADTFKEAMLAVAQNLVVINPEDVTYVSTFRNGTLFHR----------------MRHSDC 348
                      |.|:|...:.|:.:..|   |....||.|.|..                .:..:.
  Rat   266 ----------KGAILLQDKKLMAMFLE---YNKAIRNYTHFDDWYLWVQMYKGTVSMPVFQSLEA 317

  Fly   349 FAGGLFVL-----GAAETQMKHWEKYAHIGIGLTDTCHDSYWSSPTRLGPDTFAFTEESQQEIEP 408
            :..||..|     .|..|.:.::..:...| ||.:     :::.|.       .:|.|
  Rat   318 YWPGLQSLIGDIDNAMRTFLNYYTVWKQFG-GLPE-----FYNIPQ-------GYTVE------- 362

  Fly   409 LQRNYYNLRPEVAETYLVLWRITHHPQYRLWGLEMVQAIEKYCRMPYGYTGVMDVNNVTSEPDDV 473
             :|..|.||||:.|:.:.|:|.|..|.....|.:.|::|||..::..|:..:.|:.:  .:.|:.
  Rat   363 -KREGYPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRD--HKLDNR 424

  Fly   474 QGSFFLGSTLKYLYLLFSDDD-------------------VVSLEQWVFNSAGHFLPI 512
            ..||||..|:|||||||..::                   ::....::||:..|  ||
  Rat   425 MESFFLAETVKYLYLLFHPNNFIHNNGSTFDSVMTPHGECILGAGGYIFNTEAH--PI 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-Ic	NP_733331.1	Glyco_hydro_47	78..512	CDD:279825	119/490 (24%)
Edem2	NP_001004230.1	Glyco_hydro_47	42..480	CDD:396217	119/490 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343596
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840