DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Man-Ic and Man1a2

DIOPT Version :9

Sequence 1:	NP_733331.1	Gene:	alpha-Man-Ic / 318624	FlyBaseID:	FBgn0051202	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001099922.1	Gene:	Man1a2 / 295319	RGDID:	1309767	Length:	641	Species:	Rattus norvegicus

Alignment Length:	466	Identity:	193/466 - (41%)
Similarity:	278/466 - (59%)	Gaps:	30/466 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 NPDD-----MRAKIKEMMMHAWRNYARVVWGTNEFRPISRRVHFGGDFATYKLGATIIESLDTLH 126
            :|:|     .|.||||||.|||.||....||.||.|||:|:.|....|.:.::||||:::||||:
  Rat   171 DPEDAEIRKKRDKIKEMMKHAWDNYRTYGWGHNELRPIARKGHSTNIFGSSQMGATIVDALDTLY 235

  Fly   127 LMGLNKELRRSRDWIEKSFHLDRVDEALSVYELTSRLLCPMLTLYSLTGDSLYMDKAIHIADKIL 191
            :|||:.|....:.|||.:.... |:..:||:|:..|.:..:|..|.|:|:.::..||:.:|:|:|
  Rat   236 IMGLHDEFMDGQRWIEDNLDFS-VNSEVSVFEVNIRFIGGLLAAYYLSGEEIFKTKAVQLAEKLL 299

  Fly   192 PAFDTPTGIPRRLVVPKEGSTLTKYLSDISRT-----------SEFGSLHLEFYYLSEVSGYPVY 245
            |||:||||||..:|..|.|         :.|.           :|||:||:||.:||.::|...|
  Rat   300 PAFNTPTGIPWAMVNLKSG---------VGRNWGWASAGSSILAEFGTLHMEFVHLSYLTGDLTY 355

  Fly   246 RERVDAIREILAKTTRPNGLYPNAYCTKFGKWENYNCSMHRL----YDTLLKSWIQSGRTDTQNA 306
            ..:|..||::|.|..||||||||....:.|:|..|:.|:..|    |:.|||:|:.|.:||.:..
  Rat   356 YNKVMHIRKLLQKMERPNGLYPNYLNPRTGRWGQYHTSVGGLGDSFYEYLLKAWLMSDKTDHEAR 420

  Fly   307 DTFKEAMLAVAQNLVVINPEDVTYVSTFRNGTLFHRMRHSDCFAGGLFVLGAAETQMKHWEKYAH 371
            ..:.:|:.|:.::|:..:...:.::..::||.|..:|.|..|||||:|.|||..::......|..
  Rat   421 RMYDDAVEAIEKHLIKKSRGGLVFIGEWKNGHLERKMGHLACFAGGMFALGADGSRKDKAGHYLE 485

  Fly   372 IGIGLTDTCHDSYWSSPTRLGPDTFAFTEESQQEIEPLQRNYYNLRPEVAETYLVLWRITHHPQY 436
            :|..:..|||:||..:..:|||::|.|....:.........||.|||||.|||..|||.||.|:|
  Rat   486 LGAEIARTCHESYDRTALKLGPESFKFDGAVEAVAVRQAEKYYILRPEVIETYWYLWRFTHDPRY 550

  Fly   437 RLWGLEMVQAIEKYCRMPYGYTGVMDVNNVTSEPDDVQGSFFLGSTLKYLYLLFSDDDVVSLEQW 501
            |.||.|...||||.||:..|::||.||.:.|...||||.||||..||||||||||.||::.|:.|
  Rat   551 RQWGWEAALAIEKSCRVSGGFSGVKDVYSPTPAHDDVQQSFFLAETLKYLYLLFSGDDLLPLDHW 615

  Fly   502 VFNSAGHFLPI 512
            |||:..|.||:
  Rat   616 VFNTEAHPLPV 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-Ic	NP_733331.1	Glyco_hydro_47	78..512	CDD:279825	185/448 (41%)
Man1a2	NP_001099922.1	ATP-synt_B	<107..151	CDD:304375
Man1a2	NP_001099922.1	Glyco_hydro_47	187..626	CDD:279825	185/448 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343604
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2204
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54359
OrthoDB	1	1.010	-	-		D263455at33208
OrthoFinder	1	1.000	-	-		FOG0001280
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100239
Panther	1	1.100	-	-	O	PTHR11742
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X635
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.720