DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Man-Ic and Man1a1

DIOPT Version :9

Sequence 1:	NP_733331.1	Gene:	alpha-Man-Ic / 318624	FlyBaseID:	FBgn0051202	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	XP_006256559.1	Gene:	Man1a1 / 294410	RGDID:	1310891	Length:	746	Species:	Rattus norvegicus

Alignment Length:	462	Identity:	191/462 - (41%)
Similarity:	278/462 - (60%)	Gaps:	34/462 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 DMRAKIKEMMMHAWRNYARVVWGTNEFRPISRRVHFGGDFATYKLGATIIESLDTLHLMGLNKEL 134
            :.|:||||||.|||.||.|..||.||.:|||:..|....|...| ||||:::||||.:||:..|.
  Rat   287 EKRSKIKEMMAHAWNNYKRYAWGLNELKPISKEGHSSSLFGNIK-GATIVDALDTLFIMGMKTEF 350

  Fly   135 RRSRDWIEKSFHLD-RVDEALSVYELTSRLLCPMLTLYSLTGDSLYMDKAIHIADKILPAFDTPT 198
            :.::.||:|  :|| .|:..:||:|:..|.:..:|:.|.|:|:.::..||:.:..|:||||.:|:
  Rat   351 QEAKSWIKK--YLDFNVNAEVSVFEVNIRFVGGLLSAYYLSGEEIFRKKAVELGVKLLPAFHSPS 413

  Fly   199 GIPRRLVVPKEGSTLTKYLSDISRT-----------SEFGSLHLEFYYLSEVSGYPVYRERVDAI 252
            |||..|:..|.|         |.|.           :|||:|||||.:|:.:||.||:.|:|..|
  Rat   414 GIPWALLNMKSG---------IGRNWPWASGGSSILAEFGTLHLEFMHLAHLSGNPVFAEKVMNI 469

  Fly   253 REILAKTTRPNGLYPNAYCTKFGKWENYNCSMHRL----YDTLLKSWIQSGRTDTQNADTFKEAM 313
            |.:|.|..:|.|||||......|:|..::.|:..|    |:.|||:|:.|.:||.:....:.:|:
  Rat   470 RTVLNKLDKPEGLYPNYLNPSSGQWGQHHVSVGGLGDSFYEYLLKAWLMSDKTDLEAKKMYFDAV 534

  Fly   314 LAVAQNLVVINPEDVTYVSTFRNGTLFHRMRHSDCFAGGLFVL---GAAETQMKHWEKYAHIGIG 375
            .|:..:|:..:...:||::.::.|.|.|:|.|..|||||:|.|   ||.|.:.:|   |..:|..
  Rat   535 QAIETHLIRKSSGGLTYIAEWKGGLLEHKMGHLTCFAGGMFALGADGAPEARAQH---YLELGAE 596

  Fly   376 LTDTCHDSYWSSPTRLGPDTFAFTEESQQEIEPLQRNYYNLRPEVAETYLVLWRITHHPQYRLWG 440
            :..|||:||..:..:|||:.|.|....:.........||.|||||.|||:.:||:||.|:||.|.
  Rat   597 IARTCHESYNRTYVKLGPEAFRFDGGVEAIATRQNEKYYILRPEVIETYMYMWRLTHDPKYRTWA 661

  Fly   441 LEMVQAIEKYCRMPYGYTGVMDVNNVTSEPDDVQGSFFLGSTLKYLYLLFSDDDVVSLEQWVFNS 505
            .|.|:|:|.:||:..||:|:.||.......||||.||||..|||||||:|||||::.||.|:||:
  Rat   662 WEAVEALESHCRVNGGYSGLRDVYIAHESYDDVQQSFFLAETLKYLYLIFSDDDLLPLEHWIFNT 726

  Fly   506 AGHFLPI 512
            ..|..||
  Rat   727 EAHPFPI 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-Ic	NP_733331.1	Glyco_hydro_47	78..512	CDD:279825	184/452 (41%)
Man1a1	XP_006256559.1	Glyco_hydro_47	295..733	CDD:279825	184/452 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343602
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2204
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54359
OrthoDB	1	1.010	-	-		D263455at33208
OrthoFinder	1	1.000	-	-		FOG0001280
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100239
Panther	1	1.100	-	-	O	PTHR11742
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X635
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.720