Protein Alignment alpha-Man-Ic and Man1b1

DIOPT Version :10

• Sequence 1: NP_733331.1
• Gene: alpha-Man-Ic / 318624
• FlyBaseID: FBgn0051202
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_001025154.1
• Gene: Man1b1 / 227619
• MGIID: 2684954
• Length: 658
• Species: Mus musculus
• Alignment Length: 748
• Identity: 139/748 - (18%)
• Similarity: 248/748 - (33%)
• Gaps: 257/748 - (34%)

  Fly     5 TETNKDSFLVQTKAAREERAHERA-----QEERRDRSILLLQRTIRGWLARTKFRQRI------- 57
            :|..::...:|.:..|.|...:||     :|.::.|...|...:::        ||.:
Mouse  1163 SELEQEKQSLQNELDRREEQFQRARARDDEEHKKARGAELEYESLK--------RQELESENKKL 1219

  Fly    58 ---LNEFDELLPPVTNAGKPIELKPSLTV----YGAASHFL--------------------LQWK 95
               ||:..:.|.....||......|:.||    ..|::..|                    :|.|
Mouse  1220 KHDLNQMRQSLRGSVEAGSGAPGSPAYTVLLDQLNASNEELEVRKEEVLILRSQLVSQKEAMQHK 1284

  Fly    96 AE-TSAPESAPHRERLERLCRYLVASLDSDSPKTSYIGVAFNKELSLAW--IRHIKKLLYRCCTA 157
            .| |:..|..|:.|.:::|         :|:           ||:|.|:  ::...:||.....|
Mouse  1285 DEKTTMTEPLPYIEDVQKL---------TDA-----------KEISQAYMGLKDTNRLLESQLQA 1329

  Fly   158 --------IELLKPEVHSDSITLALYLHTLVAFTSINSWALLRNKALAGLKPGMTQLCANVMGDL 214
                    :|:|:.|           ||:|....:.....|.:|..|    |...::.|::..::
Mouse  1330 QRRSHDNEVEVLRGE-----------LHSLKEENNRQQQLLAQNLQL----PPEARIEASLQHEI 1379

  Fly   215 VQKGFYLTLRNVLVKGTCRPVVNLKPISLTALVTLALRPLVSSGFSENLLSQFLVQILSVPGMMM 279
            .:    ||..|:.:...       .|....|.....||.:|      :|:.|...|..:|..:..
Mouse  1380 TR----LTNENLELHSD-------DPKEYKAYRISMLRRMV------DLMEQLEKQDKTVRKLKK 1427

  Fly   280 QLEQYTPECLVSVQSHGTLE-KTLDLLSGEQSTKFV--------------VASLQNSNLLALLAN 329
            ||:       |..:....|| ..:|:..|:.:.:.|              :...:..:.|.|:.|
Mouse  1428 QLK-------VFAKKINDLEGGQMDVSPGQTADEPVHPVNIPRREKDFQGMLEYKKEDELKLVKN 1485

  Fly   330 IV--------------------------HLYYLEAPENAAKLAYPAFTFVVTQLLNGILNSLSQA 368
            |:                          |..|:...:....|        :|.::|.|...|.:.
Mouse  1486 IILELKPRGVAVNLIPGLPAYILFMCLRHADYINDDQKVRSL--------LTSVINSIKKILKKR 1542

  Fly   369 GGAFTQWHELLGWFS------------PGKDRLQHENLPLIKKQIHLLWN--------------- 406
            |..|   ..:..|.:            .|.::....|.|  |:..|.|.|
Mouse  1543 GDDF---ETVSFWLANTCRFLHCLKQYSGDEQFMKHNSP--KQNEHCLSNFDLAEYRQVLSDLAI 1602

  Fly   407 ---HRIVKLLLGDN-LKELAVG----YETIDYPIPSGNSTGNLLKRAL------TFERSSMKGQP 457
               .:::|.:  :| |:.:.|.    :|||..  .||.....|.||..      |:...|:..|.
Mouse  1603 QIYQQLIKCM--ENILQPMIVSGMLEHETIQG--VSGVKPTGLRKRTSSIADEGTYTLDSIIRQL 1663

  Fly   458 NKAGKMYRKLGC-----AEVSRVALTCSMYHAALSALSQ--LRLDILS-----GLCYNDTVLHDL 510
            |    .:..:.|     .|:.:..:....|......|:.  ||.|:.|     .:.||.:.|.:
Mouse  1664 N----TFHSIMCHHGTDPELIKQVVKQQFYIIGAVTLNNLLLRKDMCSWSKGMQIRYNVSQLEE- 1723

  Fly   511 WLLLGSIGPNCGLKGFIE-------LLQVSQTNYAPPLLLLSLFCDCMTHYVTILDDLEMYEQQT 568
            ||...:: ..||.|..:|       ||||.:........:.|: |:.::            ..|.
Mouse  1724 WLRDKNL-MTCGAKETLEPLIQAAQLLQVKKKTDEDAEAICSM-CNALS------------TAQI 1774

  Fly   569 PFTLNDYIVLSHF---LNTFLYRTIQDQILDAK 598
            ...||.|..::.|   ::....||||.::.|.|
Mouse  1775 VKVLNLYTPVNAFEERVSVLFIRTIQTRLRDRK 1807

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-Ic	NP_733331.1	Glyco_hydro_47	78..512	CDD:460241	100/562 (18%)
Man1b1	NP_001025154.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	123..142
		Glyco_hydro_47	215..654	CDD:460241