DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Man-Ic and Man1a2

DIOPT Version :9

Sequence 1:	NP_733331.1	Gene:	alpha-Man-Ic / 318624	FlyBaseID:	FBgn0051202	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_034893.1	Gene:	Man1a2 / 17156	MGIID:	104676	Length:	641	Species:	Mus musculus

Alignment Length:	466	Identity:	194/466 - (41%)
Similarity:	279/466 - (59%)	Gaps:	30/466 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 NPDDM-----RAKIKEMMMHAWRNYARVVWGTNEFRPISRRVHFGGDFATYKLGATIIESLDTLH 126
            :|:||     |.||||||.|||.||....||.||.|||:|:.|....|.:.::||||:::||||:
Mouse   171 DPEDMEIKKKRDKIKEMMKHAWDNYRTYGWGHNELRPIARKGHSTNIFGSSQMGATIVDALDTLY 235

  Fly   127 LMGLNKELRRSRDWIEKSFHLDRVDEALSVYELTSRLLCPMLTLYSLTGDSLYMDKAIHIADKIL 191
            :|||:.|....:.|||::.... |:..:||:|:..|.:..:|..|.|:|:.::..||:.:|:|:|
Mouse   236 IMGLHDEFMDGQRWIEENLDFS-VNSEVSVFEVNIRFIGGLLAAYYLSGEEIFKTKAVQLAEKLL 299

  Fly   192 PAFDTPTGIPRRLVVPKEGSTLTKYLSDISRT-----------SEFGSLHLEFYYLSEVSGYPVY 245
            |||:||||||..:|..|.|         :.|.           :|||:||:||.:||.::|...|
Mouse   300 PAFNTPTGIPWAMVNLKSG---------VGRNWGWASAGSSILAEFGTLHMEFVHLSYLTGDLTY 355

  Fly   246 RERVDAIREILAKTTRPNGLYPNAYCTKFGKWENYNCSMHRL----YDTLLKSWIQSGRTDTQNA 306
            ..:|..||::|.|..||||||||....:.|:|..|:.|:..|    |:.|||:|:.|.:||.:..
Mouse   356 YNKVMHIRKLLQKMERPNGLYPNYLNPRTGRWGQYHTSVGGLGDSFYEYLLKAWLMSDKTDHEAR 420

  Fly   307 DTFKEAMLAVAQNLVVINPEDVTYVSTFRNGTLFHRMRHSDCFAGGLFVLGAAETQMKHWEKYAH 371
            ..:.:|:.|:.::|:..:...:.::..::||.|..:|.|..|||||:|.|||..::......|..
Mouse   421 RMYDDAVEAIEKHLIKKSRGGLVFIGEWKNGHLERKMGHLACFAGGMFALGADGSRKDKAGHYLE 485

  Fly   372 IGIGLTDTCHDSYWSSPTRLGPDTFAFTEESQQEIEPLQRNYYNLRPEVAETYLVLWRITHHPQY 436
            :|..:..|||:||..:..:|||::|.|....:.........||.|||||.|||..|||.||.|:|
Mouse   486 LGAEIARTCHESYDRTALKLGPESFKFDGAVEAVAVRQAEKYYILRPEVIETYWYLWRFTHDPRY 550

  Fly   437 RLWGLEMVQAIEKYCRMPYGYTGVMDVNNVTSEPDDVQGSFFLGSTLKYLYLLFSDDDVVSLEQW 501
            |.||.|...||||.||:..|::||.||...|...||||.||||..||||||||||.||::.|:.|
Mouse   551 RQWGWEAALAIEKSCRVSGGFSGVKDVYAPTPVHDDVQQSFFLAETLKYLYLLFSGDDLLPLDHW 615

  Fly   502 VFNSAGHFLPI 512
            |||:..|.||:
Mouse   616 VFNTEAHPLPV 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-Ic	NP_733331.1	Glyco_hydro_47	78..512	CDD:279825	185/448 (41%)
Man1a2	NP_034893.1	Neuromodulin_N	<109..208	CDD:331332	20/36 (56%)
Man1a2	NP_034893.1	Glyco_hydro_47	187..626	CDD:307602	185/448 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839764
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2204
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1331
OMA	1	1.010	-	-		QHG54359
OrthoDB	1	1.010	-	-		D263455at33208
OrthoFinder	1	1.000	-	-		FOG0001280
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100239
Panther	1	1.100	-	-	O	PTHR11742
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X635
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.670