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Protein Alignment alpha-Man-Ic and MAN1A2

DIOPT Version :10

Sequence 1:	NP_733331.1	Gene:	alpha-Man-Ic / 318624	FlyBaseID:	FBgn0051202	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_006690.1	Gene:	MAN1A2 / 10905	HGNCID:	6822	Length:	641	Species:	Homo sapiens

Alignment Length:	468	Identity:	195/468 - (41%)
Similarity:	282/468 - (60%)	Gaps:	30/468 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 DNSLKDMNPDDMRAKIKEMMMHAWRNYARVVWGTNEFRPISRRVHFGGDFATYKLGATIIESLDT 124
            ||.::     :.|.||||||.|||.||....||.||.|||:|:.|....|.:.::||||:::|||
Human   174 DNDIR-----EKREKIKEMMKHAWDNYRTYGWGHNELRPIARKGHSPNIFGSSQMGATIVDALDT 233

  Fly   125 LHLMGLNKELRRSRDWIEKSFHLDRVDEALSVYELTSRLLCPMLTLYSLTGDSLYMDKAIHIADK 189
            |::|||:.|....:.|||.:.... |:..:||:|:..|.:..:|..|.|:|:.::..||:.:|:|
Human   234 LYIMGLHDEFLDGQRWIEDNLDFS-VNSEVSVFEVNIRFIGGLLAAYYLSGEEIFKIKAVQLAEK 297

  Fly   190 ILPAFDTPTGIPRRLVVPKEGSTLTKYLSDISRT-----------SEFGSLHLEFYYLSEVSGYP 243
            :||||:||||||..:|..|.|         :.|.           :|||:||:||.:||.::|..
Human   298 LLPAFNTPTGIPWAMVNLKSG---------VGRNWGWASAGSSILAEFGTLHMEFIHLSYLTGDL 353

  Fly   244 VYRERVDAIREILAKTTRPNGLYPNAYCTKFGKWENYNCSMHRL----YDTLLKSWIQSGRTDTQ 304
            .|.::|..||::|.|..||||||||....:.|:|..|:.|:..|    |:.|||:|:.|.:||.:
Human   354 TYYKKVMHIRKLLQKMDRPNGLYPNYLNPRTGRWGQYHTSVGGLGDSFYEYLLKAWLMSDKTDHE 418

  Fly   305 NADTFKEAMLAVAQNLVVINPEDVTYVSTFRNGTLFHRMRHSDCFAGGLFVLGAAETQMKHWEKY 369
            ....:.:|:.|:.::|:..:...:|::..::||.|..:|.|..|||||:|.|||..::......|
Human   419 ARKMYDDAIEAIEKHLIKKSRGGLTFIGEWKNGHLEKKMGHLACFAGGMFALGADGSRADKAGHY 483

  Fly   370 AHIGIGLTDTCHDSYWSSPTRLGPDTFAFTEESQQEIEPLQRNYYNLRPEVAETYLVLWRITHHP 434
            ..:|..:..|||:||..:..:|||::|.|....:.........||.|||||.|||..|||.||.|
Human   484 LELGAEIARTCHESYDRTALKLGPESFKFDGAVEAVAVRQAEKYYILRPEVIETYWYLWRFTHDP 548

  Fly   435 QYRLWGLEMVQAIEKYCRMPYGYTGVMDVNNVTSEPDDVQGSFFLGSTLKYLYLLFSDDDVVSLE 499
            :||.||.|...|||||||:..|::||.||.:.|...||||.||||..||||||||||.||::.|:
Human   549 RYRQWGWEAALAIEKYCRVNGGFSGVKDVYSSTPTHDDVQQSFFLAETLKYLYLLFSGDDLLPLD 613

  Fly   500 QWVFNSAGHFLPI 512
            .||||:..|.||:
Human   614 HWVFNTEAHPLPV 626

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.