DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Man-Ic and man1a2

DIOPT Version :9

Sequence 1:	NP_733331.1	Gene:	alpha-Man-Ic / 318624	FlyBaseID:	FBgn0051202	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	XP_002943491.1	Gene:	man1a2 / 100216029	XenbaseID:	XB-GENE-1010312	Length:	643	Species:	Xenopus tropicalis

Alignment Length:	478	Identity:	192/478 - (40%)
Similarity:	287/478 - (60%)	Gaps:	34/478 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 NIPSNDNSLKDMNPDD-----MRAKIKEMMMHAWRNYARVVWGTNEFRPISRRVHFGGDFATYKL 114
            |:|    .:|:.:|.|     .|.||||||.|||.||.:..||.||.:||:|:.|....|...::
Frog   165 NLP----EIKNGDPGDPDIREKRDKIKEMMKHAWDNYKQYGWGHNELKPIARKGHSTNIFGNSQM 225

  Fly   115 GATIIESLDTLHLMGLNKELRRSRDWIEKSFHLDRVDEALSVYELTSRLLCPMLTLYSLTGDSLY 179
            ||||:::||:|::|||..|.|..::|::.:.... |:..:||:|:..|.:..:|..:.|:|..::
Frog   226 GATIVDALDSLYIMGLLDEFREGQEWVQNNLDFS-VNAEVSVFEVNIRFIGGLLAAFYLSGQEVF 289

  Fly   180 MDKAIHIADKILPAFDTPTGIPRRLVVPKEGSTLTKYLSDISRT-----------SEFGSLHLEF 233
            .:||:.:|:|:||||:||||||..:|..|.|         :.|.           :|||:|||||
Frog   290 KNKAVLLAEKLLPAFNTPTGIPWAMVNLKTG---------VGRNWGWASAGSSILAEFGTLHLEF 345

  Fly   234 YYLSEVSGYPVYRERVDAIREILAKTTRPNGLYPNAYCTKFGKWENYNCSMHRL----YDTLLKS 294
            .:||.::|.|||..:|..||::|.|..|||||:||....:.|:|..::.|:..|    |:.|||:
Frog   346 VHLSYLTGNPVYYNKVMHIRKLLQKMDRPNGLFPNYLNPRTGRWGQHHTSVGGLGDSFYEYLLKA 410

  Fly   295 WIQSGRTDTQNADTFKEAMLAVAQNLVVINPEDVTYVSTFRNGTLFHRMRHSDCFAGGLFVLGAA 359
            |:.|.|:|.:....:..|:.|:.::||..:...:|::..::||.|..:|.|..|||||:..|||.
Frog   411 WLVSDRSDIEARHMYDSAIEAIERHLVRKSSGGLTFIGEWKNGHLERKMGHLTCFAGGMLALGAD 475

  Fly   360 ETQMKHWEKYAHIGIGLTDTCHDSYWSSPTRLGPDTFAFTEESQQEIEPLQRNYYNLRPEVAETY 424
            .:..:....|..:|..:..|||:||..:..:|||:.|.|...::.........||.|||||.|||
Frog   476 GSPGEKAGHYLQLGAEIAHTCHESYDRTVLKLGPEAFKFDGGAEAVAVRQNEKYYILRPEVIETY 540

  Fly   425 LVLWRITHHPQYRLWGLEMVQAIEKYCRMPYGYTGVMDVNNVTSEPDDVQGSFFLGSTLKYLYLL 489
            ..:||.||.|:||.||.|..|||:||||:..|::|:.||.:.:...||||.||||..||||||||
Frog   541 WYMWRFTHDPKYRRWGWEAAQAIDKYCRVSGGFSGIKDVYSSSPTYDDVQQSFFLAETLKYLYLL 605

  Fly   490 FSDDDVVSLEQWVFNSAGHFLPI 512
            ||.||::.|:.||||:..|.||:
Frog   606 FSSDDLLPLDNWVFNTEAHPLPV 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-Ic	NP_733331.1	Glyco_hydro_47	78..512	CDD:279825	181/448 (40%)
man1a2	XP_002943491.1	ATP-synt_B	<110..153	CDD:389759
man1a2	XP_002943491.1	Glyco_hydro_47	189..628	CDD:366693	181/448 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D263455at33208
OrthoFinder	1	1.000	-	-		FOG0001280
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11742
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X635
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.110