DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIE and GLR1.3

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_199652.1	Gene:	GLR1.3 / 834896	AraportID:	AT5G48410	Length:	860	Species:	Arabidopsis thaliana

Alignment Length:	951	Identity:	186/951 - (19%)
Similarity:	379/951 - (39%)	Gaps:	214/951 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FVILWSLFSIHISVNWAQYENFGGYDNYQSLESVPIGLLTD---------QNTEQMNIVFDHAI- 60
            |:::..||   ||.::|..:| ...|..:.:: :.:||:.|         :|:..|.:.:.:||
plant    14 FLLVLLLF---ISRSFASTKN-DDVDGGKRVQ-IRVGLVLDLGSLKGKIVKNSVSMALSYFYAIH 73

  Fly    61 DVANQEVGTSLTSLKEEVNYGDAYQSYGKLCRMLET-GIAGVFGPSSRHTAVHLMSICDAMDIPH 124
            :.....|..||.:     ::|:...:......:|:| |:..:.|.:|...|..|..:.:...:|.
plant    74 NDYKTRVSVSLRN-----SHGEPLLALASAVDLLKTEGVEAIIGGNSLLEAKLLGELGEKARVPM 133

  Fly   125 I------------YSYMSENAEGFNLHPHPADLAKALYSLITEFNWTRFIFLYES----AEYLNI 173
            |            |:::.:..     |...:: ||.:.|.|..|:|.....:||.    .|.:.:
plant   134 ISLDSPFSLSLSKYTHLIQAT-----HDSTSE-AKGITSFINVFDWNSVALVYEDHDDWRESMQL 192

  Fly   174 LNELTTMLG---KSGTVITVLRYDMQLNGNYKQVLRRVRKSVDNRIVVVGSSETMPEFLNQ-AQQ 234
            |.|.....|   :|....||...:..:.|..:|:     |.:...:.||..||.:...|.. |::
plant   193 LVEHFHENGVRVQSKVGFTVSSSEDFVMGRLQQL-----KDLGTTVFVVHLSEVIATHLFPCARR 252

  Fly   235 VGIINEDYKYIIGNLDFHSF--DLEEY-KYSEANITGLRLFSPEKMAVKE--LLMKLGYPTDQDE 294
            :|::.:.:.:|:.....:||  ::::: |.:...:.|.:.:.|..:.::.  |..:...|.::.|
plant   253 LGLMGDGFVWILTAKTMNSFHENIDDFTKQAMEGVVGFKSYIPMSIELQNFTLRWRKSLPVEEAE 317

  Fly   295 FRNGSCPITVEMALTYD---AVQLFAQTLKNLPFKPMPQNCSQRTESVRDDGSSFKNYMRTLRLT 356
            ...    :::.....:|   |:...|:.::      ||...|...|.:..  :.|.......:|.
plant   318 LTR----LSISGIWAHDIAFALARAAEVIR------MPNVTSTLLEEITK--TRFNGLSGDFQLN 370

  Fly   357 DRLLTGPIYFEGNVRKGYHLDVIELQPSGIVKVGTWDEDRQYRPQR-LAPTTAQFDSV------- 413
            |:.|....:           ::|.:..|...:||..:.:..:..:| |:.|..:.:::
plant   371 DKKLLSNKF-----------EIINMIGSSERRVGFLNSNGSFSNRRHLSSTHNKLETIIWPGGSA 424

  Fly   414 ----DNSLAN---KTFIILLSVPNK-PYAQLVETYKQLEGNSQYEGYGVDLIKELADKLGFNFTF 470
                ..||.:   |...:|::..|: |....||| ..:......||:.:::.:.......:...:
plant   425 QSPKGTSLIDSDRKKLRVLVTSSNRFPRLMKVET-DPVTNELIVEGFCIEVFRASISPFNYEVEY 488

  Fly   471 V---NGGN-DYGSYNKSTNESTGMLREIMTGRADLAITDLTITSEREQALDFTIPFMNLGIAILY 531
            :   ||.| |..:|...:.:.          :.|.|:.|:||||.|...:|||:||..:|:.|:.
plant   489 IPWLNGSNYDNLAYALHSQKD----------KYDAAVGDITITSNRSTYVDFTLPFTEMGLGIVA 543

  Fly   532 LKPQKATPELFTFMDPFSEEVWWFLGFSFLGVSLSFFILGRLSPSEWDNPYPCIEEPEELENQFT 596
            :|.:    .::.|..|.:.::|....|.|:...:..:::.|....|:...:|           ..
plant   544 VKER----SMWVFFQPLTPDLWITSAFFFVLTGVIVWLIERAENKEFQGSWP-----------QQ 593

  Fly   597 LGNSIWFTTGALLQQGSEIGPKALSTRTVASFWWFFTLIVVSSYTANLAAFLTIEKPQSLINSVD 661
            :|..:||....|:....|.....|| |.|.:.|.|..||:.:||||.|.:.:|::  |...||.:
plant   594 IGVVLWFGFSTLVYAHREKLKHNLS-RFVVTVWVFAVLILTASYTATLTSMMTVQ--QIRFNSNE 655

  Fly   662 DLADNKDG-VVYGAKKTGST----RNFFMTSAEERYKK--MNKFMS--------------ENPQY 705
            |...:..| ::.....|.|:    |:..:.||.: |.:  :||.:|              |||
plant   656 DYVGHLSGSLIANVALTSSSLRAMRSLGLNSAAD-YAQALLNKTVSFVVDELPYLKVVLGENP-- 717

  Fly   706 LTEDNMEGVNRVKTNTHYAFLMESTSIEYNTKRECNLKKIGDALDEKGYGIAMRKDWPHRGKFNN 770
                           ||: |::::.|                  ...|:|...:|.:......:.
plant   718 ---------------THF-FMVKTQS------------------TTNGFGFMFQKGFELVPNVSR 748

  Fly   771 ALLELQEQGVLEKMKNKWWNEVGTGICATKEDAPDATPLDMNNLEGVFFVLLVGSCCALLYGII- 834
            .:.:|:....|.:|:.:|::   ..:..|.:|.  :.|:.:....|:|.::.|....||...:|
plant   749 EISKLRTSEKLNEMEKRWFD---NQLPYTTDDT--SNPITLYRFRGLFIIIGVSFAFALAVLVIL 808

  Fly   835 ----SWVLFV-----MKKAHHYRV---------PLRDALKE 857
                .|.:.|     .::..|:|:         ||.|.:.|
plant   809 CLRDKWEILVDNLDLSQRLRHFRIHFVRSIHTSPLDDPIGE 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	71/392 (18%)
		ANF_receptor	51..382	CDD:279440	64/360 (18%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	85/399 (21%)
		Lig_chan	551..824	CDD:278489	58/293 (20%)
GLR1.3	NP_199652.1	PBP1_GABAb_receptor	43..405	CDD:107361	71/400 (18%)
		ANF_receptor	57..385	CDD:279440	65/366 (18%)
		GluR_Plant	438..767	CDD:270404	84/394 (21%)
		Lig_chan	559..798	CDD:278489	59/294 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.930