DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIE and ATGLR1.2

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_199651.1	Gene:	ATGLR1.2 / 834895	AraportID:	AT5G48400	Length:	867	Species:	Arabidopsis thaliana

Alignment Length:	921	Identity:	180/921 - (19%)
Similarity:	339/921 - (36%)	Gaps:	205/921 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 VPIGLLTDQNTEQMNIV-----------FDHAIDVANQEVGTSLTSLKEEVNYGDAYQSYGKLCR 92
            |.:||:.|..:.:..||           :|:     :.:..|.|:.|..: ::|:...:...:..
plant    40 VRVGLVLDLGSVEGKIVRSSVSMALSDFYDN-----HNDYKTRLSLLVRD-SHGEPLLALDSVVD 98

  Fly    93 MLET-GIAGVFGPSSRHTAVHLMSICDAMDIPHIYSYMSENAEGFNLHPH-------PADLAKAL 149
            :|:| |:..:.|.:|...|..|..:.:...:| :.|..|..:...:.:.|       .|...|.:
plant    99 LLQTEGVQAIIGGNSLLEAKLLAELGEKARVP-VISLNSPMSLSLSKYTHLIQATHNSASEVKGI 162

  Fly   150 YSLITEFNWTRFIFLYESAEYLNILNELTTMLGKSGTVITVLRYDMQLNGNYKQVLRRVR--KSV 212
            .:.:..|:|.....:.|..:.................|....:....:..:...::.|:|  |.:
plant   163 TAFLHGFDWNSVALVLEDHDDWRESMHFMVDHFHENNVHVQSKVAFSVTSSEDSLMDRLRELKDL 227

  Fly   213 DNRIVVVGSSETMPEFLNQ-AQQVGIINEDYKYIIGNLDFHSF------DLEEYKYSEANITGLR 270
            ...:.||..||.:...|.. |:::|::.|.:.:|:.:....||      ||.  |.:...:.|.:
plant   228 GTTVFVVHLSEVIATRLFPCAEKLGMMGEGFAWILTSRSMSSFHDQFIDDLT--KEAMEGVVGFK 290

  Fly   271 LFSPEKMAVKELLMKLGYPTDQDEFRNGSCP-ITVEMALTYDAVQLFAQTLKNLPFKPMPQNCSQ 334
            .:.|....:....::.......:|....... :::.....:|.....|...:   ...||...|.
plant   291 SYIPMSKELHNFTLRWRKTLPVEEVTGSEITRLSISGVWAHDVAWSLASAAE---VTRMPTVTST 352

  Fly   335 RTESVRDDGSSFKNYMRTLRLTDRLLTGPIYFEGNVRKGYHLDVIELQPSGIVKVGTWDEDRQYR 399
            ..|::::  |.||......:|.|..|....:           :::.:..||..:||.|:.:..:.
plant   353 LLEAIKE--SRFKGLSGNFQLDDMKLLSDKF-----------EIVNMIGSGERRVGFWNSNGSFS 404

  Fly   400 PQRLAPTTAQFDSVDNSL-----------------ANKTFIILLSVPNK-PYAQLVETYKQLEGN 446
            .:|...:|  .|:::..:                 ..|...:|::..|: |....|||.......
plant   405 NRRQLSST--HDNLETIIWPGGSAQSPKGRSLRESGRKKLRVLVTSSNRFPRLMKVETDPITHEI 467

  Fly   447 SQYEGYGVDLIKELADKLGFNF-----TFVNGGNDYGSYNKSTNESTGMLREIMTGRADLAITDL 506
            :..||:.:::.:  |....||:     .::||.|    |.|     ..........:.|.|:.|:
plant   468 TIVEGFCIEVFQ--ASIAPFNYEVEYIRWLNGTN----YTK-----LAYALHSQKDKYDAAVGDI 521

  Fly   507 TITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWFLGFSFLGVSLSFFILG 571
            ||||:|...:|||:|:..:|:.|:..|.:    .::.|..|.:..:|.        .|.:||:|.
plant   522 TITSDRSMYVDFTLPYTEMGLGIVAAKER----SMWVFFQPLTPNLWI--------TSAAFFVLT 574

  Fly   572 RLSPSEWDNPYPCIEEPEELENQFT----LGNSIWFTTGALLQQGSEIGPKALSTRTVASFWWFF 632
            .:  ..|     .||..|..|.|.:    :|..|||....|:....|.....|| |.|.:.|.|.
plant   575 GI--IVW-----LIERAENKEFQGSWPQQIGVVIWFGFSTLVYAHREKLQHNLS-RFVVTVWVFA 631

  Fly   633 TLIVVSSYTANLAAFLTIEKPQSLINSVDDLADNKDG-VVYGAKKTGSTRNFFM-----TSAEER 691
            .||:|:||||.|.:.:|::  |...|:.:|...:..| ::..|..|.|:.....     ||.:..
plant   632 VLILVTSYTATLTSMMTVQ--QIRFNANEDYVGHLSGSLIANAALTNSSLRAMRLLGLNTSEDYA 694

  Fly   692 YKKMNKFMS--------------ENPQYLTEDNMEGVNRVKTNTHYAFLMESTSIEYNTKRECNL 742
            ...|||.:|              |||.:                   |||..|....|
plant   695 QALMNKSVSYIVSELPYLKILLGENPGH-------------------FLMVKTQSTTN------- 733

  Fly   743 KKIGDALDEKGYGIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVGTGICATKEDAPDAT 807
                      |:|...:|........:..:.:|:....|.:|:.:|:::   .:..|.:|.  :.
plant   734 ----------GFGFMFQKGSELAPNVSREIAKLRTSERLNEMERRWFDK---QLPYTTDDT--SN 783

  Fly   808 PLDMNNLEGVFFVLLVGSCCALLYGIISWVLFVMKKAHHYRVPLRDALKEEFQFVIDFNNYVRVL 872
            |:.:....|:|.:..|....||...:|.|                  |:|.::          :|
plant   784 PITLYRFRGLFMITGVSFAFALAVLLILW------------------LRERWE----------IL 820

  Fly   873 KNSASIYSRSR 883
            .||.:||...|
plant   821 VNSVNIYFSQR 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	64/382 (17%)
		ANF_receptor	51..382	CDD:279440	56/359 (16%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	94/400 (24%)
		Lig_chan	551..824	CDD:278489	65/296 (22%)
ATGLR1.2	NP_199651.1	PBP1_GABAb_receptor	41..407	CDD:107361	64/390 (16%)
		ANF_receptor	55..387	CDD:279440	56/356 (16%)
		GluR_Plant	440..770	CDD:270404	93/398 (23%)
		Lig_chan	563..801	CDD:278489	66/296 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.930