DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIE and GLR2.9

DIOPT Version :9

Sequence 1:	NP_001036733.1	Gene:	GluRIIE / 318623	FlyBaseID:	FBgn0051201	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_001325277.1	Gene:	GLR2.9 / 817458	AraportID:	AT2G29100	Length:	942	Species:	Arabidopsis thaliana

Alignment Length:	980	Identity:	195/980 - (19%)
Similarity:	374/980 - (38%)	Gaps:	219/980 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FFNHFVILWSLFSIHISVNWAQYENFGGYDNYQSLESVPIGLLTDQNTEQMNI--------VFDH 58
            |.::||..:.|..:.:..|             |:.| :.:|::.|.||....|        |.|.
plant     9 FLSYFVCGFLLMGVGLGQN-------------QTSE-IKVGVVLDLNTTFSKICLTSIKMAVSDF 59

  Fly    59 AIDVANQEVGTSLTSLKEEV--NYGDAYQSYGKLCRMLET-GIAGVFGPSSRHTAVHLMSICDAM 120
            ..|..|.     ||.|...|  :..|..|:......:::| .::.:.||.:...|..::.:.:..
plant    60 YADHPNY-----LTRLTLHVRDSMEDTVQASAAALDLIKTEQVSAIIGPINSMQADFMIKLANKT 119

  Fly   121 DIPHI-YSYMSENAEGFNLHPH-------PADLAKALYSLITEFNWTRFIFLYESAE----YLNI 173
            .:|.| :|..|....... .|:       .:...:|:.|:...|.|.|.:.:|...|    ::..
plant   120 QVPTITFSATSPLLTSIK-SPYFVRATIDDSSQVRAIASIFKFFRWRRVVAIYVDNEFGEGFMPF 183

  Fly   174 LNELTTMLGKSGTVITVLRYDMQLNGNYKQVLRRVRKSVDNRIVVVGSSETMPEFLNQ-AQQVGI 237
            |.:....:....:||.....|.::....::::.|     ..|:.||....::...:.| |:.:|:
plant   184 LFDALQDVEVKRSVIPPEAIDDEIQKELRKLMER-----QARVFVVHMESSLALRVFQIARDIGM 243

  Fly   238 INEDYKYIIGNLDFH---------SFDLEEYKYSEANITGLRLFSPEKMAVKE--LLMKLGYPTD 291
            :.|.|.:::.|...|         |.:..|      .:.|:|...|:...:.:  |..|..:..:
plant   244 MEEGYVWLMTNGMTHMMRHINNGRSLNTIE------GVLGVRSHVPKSKELGDFRLRWKRTFEKE 302

  Fly   292 QDEFRNGSCPITVEMALTYDAVQLFAQTLKNLPFKPM-PQNCSQRTESVRDDGS----------- 344
            ....|:   .:.|.....||::...|:.::....|.: ..|.|..:::..|.|:
plant   303 NPSMRD---DLNVFALWAYDSITALAKAVEKANTKSLWYDNGSTLSKNRTDLGNVGVSLYGPSLQ 364

  Fly   345 ------SFKNYMRTLRLTDRLLTGP----IYFEGNVRKGYHLDVIELQPSGIVKVGTWDEDRQYR 399
                  .|.......:|.|..|..|    |.|.||..:               .:|.|
plant   365 KAFSEVRFNGLAGEFKLIDGQLQSPKFEIINFVGNEER---------------IIGFW------- 407

  Fly   400 PQRLAPTTAQFDSVDNSLANKTFI----------------------ILLSVP-NKPYAQLVE-TY 440
                   |.:...:|.:.:||..:                      :.:.|| .|.:...|: |.
plant   408 -------TPRDGLMDATSSNKKTLGPVIWPGKSKIVPKGWEIPGKKLRVGVPMKKGFFDFVKVTI 465

  Fly   441 KQLEGNSQYEGYGVDLIKELADKLGFNFTFVNGGNDYGSYNKSTNESTGMLREIMTGRADLAITD 505
            ..:.......||.:::.:....:|.:...     .:|.|: :|.|....::.::.....|..:.|
plant   466 NPITNKKTPTGYAIEIFEAALKELPYLVI-----PEYVSF-ESPNNYNNLVYQVYDKTWDAVVGD 524

  Fly   506 LTITSEREQALDFTIPFMNLGIAILYLKPQKATPELFTFMDPFSEEVWWFLGFSFLGVSLSFFIL 570
            :|||:.|....|||:||...|::::.........:.:.|::|:|.|:|...|..|:.:....::.
plant   525 ITITANRSLYADFTLPFTESGVSMMVPVRDNENKDTWVFLEPWSLELWVTTGCFFVFIGFVVWLF 589

  Fly   571 GRLSPSEWDNPYPCIEEPEELENQFTLGNSIWFTTGALLQQGSEIGPKALSTRTVASFWWFFTLI 635
            .....:::..|           .|:.:|.|:||:...::....|.....|: |.|...|.|..|:
plant   590 EHRVNTDFRGP-----------PQYQIGTSLWFSFSTMVFAHRENVVSNLA-RFVVVVWCFVVLV 642

  Fly   636 VVSSYTANLAAFLTIEKPQSLINSVDDLADNKDGVVY--GAKKTGSTRNFFMTSA-------EER 691
            :..||||:|.:|||::..|..:.:|:||..|:|.|.|  ||         |:...       |::
plant   643 LTQSYTASLTSFLTVQSLQPTVTNVNDLIKNRDCVGYQGGA---------FVKDILLGLGFHEDQ 698

  Fly   692 YKKMNKFMSENPQYLTEDNMEGVNRVKTNTHY--AFLMESTSIEYNTKRECNLKKIGDALDEKGY 754
            .|..:. ..:....|::...:|:........|  |.|.:|.|         ....:.......|:
plant   699 LKPFDS-AKDADDLLSKGKSKGIAAAFDEVAYLKAILSQSCS---------KYVMVEPTFKTGGF 753

  Fly   755 GIAMRKDWPHRGKFNNALLELQEQGVLEKMKNKWWNEVGTGICATKEDAPD-ATPLDMNNLE--- 815
            |.|..|:.|..|:|:.|:|.|.:..|.::::::|:.:        |.|.|| .|.|..|.|.
plant   754 GFAFPKNSPLTGEFSRAILNLTQNNVTQQIEDRWFPK--------KNDCPDPMTALSSNRLNLSS 810

  Fly   816 --GVFFVLLVGSCCALLYGIISWV-LFVMKKAHHYRVPLRDALKEEFQFVI------DFNNYVRV 871
              |:|  |:.|:  |:.:.::.:| ||:.:..|.......|:|..:.:|:.      |.|::  .
plant   811 FLGLF--LIAGT--AISFSLLVFVALFLYEHRHTLGDDSEDSLWRKLKFLFKIFDEKDMNSH--T 869

  Fly   872 LKNSA 876
            .||||
plant   870 FKNSA 874

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIE	NP_001036733.1	PBP1_iGluR_Kainate	42..396	CDD:107377	74/410 (18%)
		ANF_receptor	51..382	CDD:279440	68/387 (18%)
		PBP2_iGluR_Kainate	419..790	CDD:270432	86/405 (21%)
		Lig_chan	551..824	CDD:278489	68/289 (24%)
GLR2.9	NP_001325277.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		mtm1027
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.930